JP2025502627A5 - - Google Patents
Info
- Publication number
- JP2025502627A5 JP2025502627A5 JP2024534287A JP2024534287A JP2025502627A5 JP 2025502627 A5 JP2025502627 A5 JP 2025502627A5 JP 2024534287 A JP2024534287 A JP 2024534287A JP 2024534287 A JP2024534287 A JP 2024534287A JP 2025502627 A5 JP2025502627 A5 JP 2025502627A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- alkenyl
- independently selected
- lnp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163288317P | 2021-12-10 | 2021-12-10 | |
| US63/288,317 | 2021-12-10 | ||
| PCT/US2022/052347 WO2023107669A1 (en) | 2021-12-10 | 2022-12-09 | Compounds and compositions for delivery of therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025502627A JP2025502627A (ja) | 2025-01-28 |
| JP2025502627A5 true JP2025502627A5 (https=) | 2025-12-08 |
Family
ID=85076438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024534287A Pending JP2025502627A (ja) | 2021-12-10 | 2022-12-09 | 治療剤の送達のための化合物及び組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20250144036A1 (https=) |
| EP (1) | EP4444692A1 (https=) |
| JP (1) | JP2025502627A (https=) |
| CN (1) | CN118369308A (https=) |
| AR (1) | AR127892A1 (https=) |
| TW (1) | TW202333708A (https=) |
| WO (1) | WO2023107669A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CN116969850A (zh) * | 2022-06-14 | 2023-10-31 | 苏州科锐迈德生物医药科技有限公司 | 碳酸酯-羧酸酯型脂质化合物及基于其的脂质载体、核酸脂质纳米粒组合物和药物制剂 |
| WO2024067639A1 (zh) * | 2022-09-30 | 2024-04-04 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| CN116947669B (zh) * | 2022-09-30 | 2024-04-12 | 荣灿生物医药技术(上海)有限公司 | 一种转染效率高的可电离脂质化合物及其应用 |
| WO2024259373A1 (en) * | 2023-06-14 | 2024-12-19 | Modernatx, Inc. | Compounds and compositions for delivery of therapeutic agents |
| EP4736848A1 (en) * | 2023-06-28 | 2026-05-06 | Shanghai Regenelead Therapies Co., Ltd. | Pharmaceutical composition containing cationic lipid and use thereof |
| CN121889371A (zh) * | 2023-07-03 | 2026-04-17 | 科纳勒生物公司 | 脂质及其组合物 |
| CN116891423B (zh) * | 2023-07-07 | 2024-03-01 | 荣灿生物医药技术(上海)有限公司 | 脂质化合物、组合物及其制备方法和应用 |
| KR20260046133A (ko) * | 2023-07-19 | 2026-04-06 | 젠에디트바이오 리미티드 | 지질 및 지질 나노입자 |
| CN119330848B (zh) * | 2023-10-19 | 2025-07-08 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物及脂质纳米颗粒 |
| KR20250064439A (ko) * | 2023-11-02 | 2025-05-09 | 주식회사 삼양홀딩스 | 양이온성 지질 및 이의 제조방법 |
| CN117658839A (zh) * | 2023-11-22 | 2024-03-08 | 武汉大学 | 一种含羟基可电离脂质及其制备方法与应用 |
| TW202527910A (zh) * | 2023-12-13 | 2025-07-16 | 大陸商上海瑞宏迪醫藥有限公司 | 一種陽離子脂質及其應用 |
| WO2025146125A1 (zh) * | 2024-01-05 | 2025-07-10 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物和脂质纳米颗粒 |
| WO2025161943A1 (zh) * | 2024-02-02 | 2025-08-07 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物和脂质纳米颗粒 |
| CN117695410B (zh) * | 2024-02-06 | 2024-05-03 | 中国人民解放军军事科学院军事医学研究院 | CRISPR/Cas9纳米抗菌剂及其制备方法 |
| CN119264001A (zh) * | 2024-04-03 | 2025-01-07 | 上海蓝鹊生物医药有限公司 | 含氮链状化合物、制备方法、包含其的组合物和应用 |
| CN118388360B (zh) * | 2024-04-17 | 2025-04-04 | 北京悦康科创医药科技股份有限公司 | 含有苯环结构的长效脾靶向阳离子脂质化合物、包含其的组合物及用途 |
| CN118852328A (zh) * | 2024-07-02 | 2024-10-29 | 北京大学 | 肽基可离子化脂质合成及其应用 |
| CN119019272A (zh) * | 2024-08-14 | 2024-11-26 | 中国药科大学 | 可电离脂质、包含其的组合物及其用途 |
| CN119039164B (zh) * | 2024-08-29 | 2025-04-11 | 国药中生生物技术研究院有限公司 | 可离子化脂质化合物、包含其的脂质纳米颗粒、药物组合物、药物制剂及其应用 |
| WO2026061393A1 (zh) * | 2024-09-18 | 2026-03-26 | 北京剂泰生命科技有限公司 | 递送编码分泌型蛋白的核酸分子的脂质纳米颗粒及其用途 |
| WO2026081992A1 (zh) * | 2024-10-14 | 2026-04-23 | 北京剂泰生命科技有限公司 | 用于主动靶向递送的可电离脂质、其组合物和其应用 |
| CN119661389A (zh) * | 2024-10-15 | 2025-03-21 | 山东大学 | 一种基于反式-1,4-环己烷二甲醇的可电离脂质、脂质纳米颗粒及其制备方法与应用 |
| CN121426693B (zh) * | 2025-12-31 | 2026-04-03 | 中国科学技术大学苏州高等研究院 | 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用 |
| CN121426694B (zh) * | 2025-12-31 | 2026-04-03 | 中国科学技术大学苏州高等研究院 | 脂质化合物或其药学上可接受的盐及其制备方法、脂质纳米颗粒和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| EP3350333B2 (en) | 2015-09-17 | 2025-08-06 | ModernaTX, Inc. | Polynucleotides containing a stabilizing tail region |
| EP3359670B2 (en) | 2015-10-05 | 2024-02-14 | ModernaTX, Inc. | Methods for therapeutic administration of messenger ribonucleic acid drugs |
| HRP20230209T1 (hr) * | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| LT3394030T (lt) | 2015-12-22 | 2022-04-11 | Modernatx, Inc. | Junginiai ir kompozicijos terapinei medžiagai teikti intraceliuliniu būdu |
| EP4186888B1 (en) | 2017-03-15 | 2025-11-26 | ModernaTX, Inc. | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| US20230000773A1 (en) | 2019-09-19 | 2023-01-05 | Modernatx, Inc. | Novel headgroup lipid compounds and compositions for intracellular delivery of therapeutic agents |
| AU2020350759A1 (en) | 2019-09-19 | 2022-03-31 | Modernatx, Inc. | Branched tail lipid compounds and compositions for intracellular delivery of therapeutic agents |
| CA3155015A1 (en) | 2019-09-19 | 2021-03-25 | Modernatx, Inc. | Carbonate containing lipid compounds and compositions for intracellular delivery of therapeutic agents |
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2022
- 2022-12-07 AR ARP220103357A patent/AR127892A1/es unknown
- 2022-12-09 CN CN202280081536.3A patent/CN118369308A/zh active Pending
- 2022-12-09 TW TW111147301A patent/TW202333708A/zh unknown
- 2022-12-09 JP JP2024534287A patent/JP2025502627A/ja active Pending
- 2022-12-09 US US18/716,220 patent/US20250144036A1/en active Pending
- 2022-12-09 WO PCT/US2022/052347 patent/WO2023107669A1/en not_active Ceased
- 2022-12-09 EP EP22847452.4A patent/EP4444692A1/en active Pending