JP2024527940A5 - - Google Patents
Info
- Publication number
- JP2024527940A5 JP2024527940A5 JP2024504834A JP2024504834A JP2024527940A5 JP 2024527940 A5 JP2024527940 A5 JP 2024527940A5 JP 2024504834 A JP2024504834 A JP 2024504834A JP 2024504834 A JP2024504834 A JP 2024504834A JP 2024527940 A5 JP2024527940 A5 JP 2024527940A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- process according
- glycero
- membered heteroaryl
- membered heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163225822P | 2021-07-26 | 2021-07-26 | |
| US63/225,822 | 2021-07-26 | ||
| PCT/US2022/038152 WO2023009422A1 (en) | 2021-07-26 | 2022-07-25 | Processes for preparing lipid nanoparticle compositions for the delivery of payload molecules to airway epithelium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024527940A JP2024527940A (ja) | 2024-07-26 |
| JP2024527940A5 true JP2024527940A5 (https=) | 2025-08-04 |
Family
ID=82899171
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024504834A Pending JP2024527940A (ja) | 2021-07-26 | 2022-07-25 | ペイロード分子を気道上皮に送達するための脂質ナノ粒子組成物を調製するプロセス |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240366522A1 (https=) |
| EP (1) | EP4376815A1 (https=) |
| JP (1) | JP2024527940A (https=) |
| CN (1) | CN118019526A (https=) |
| TW (1) | TW202320737A (https=) |
| WO (1) | WO2023009422A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| CZ310613B6 (cs) | 2020-09-23 | 2026-01-28 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Lipidoidy pro transfekci nukleových kyselin a jejich použití |
| CZ310443B6 (cs) | 2021-07-19 | 2025-06-25 | Ústav organické chemie a biochemie AV ČR, v. v. i. | Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití |
| CN118829423A (zh) * | 2021-11-12 | 2024-10-22 | 摩登纳特斯有限公司 | 用于将有效载荷分子递送至气道上皮的组合物 |
| CN121487722A (zh) * | 2023-04-14 | 2026-02-06 | 北京剂泰生命科技有限公司 | 靶向脾的脂质纳米颗粒 |
| WO2025111297A1 (en) | 2023-11-21 | 2025-05-30 | Modernatx, Inc. | Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis |
| CN120718086A (zh) * | 2024-06-13 | 2025-09-30 | 仁景(苏州)生物科技有限公司 | 用于递送的脂质化合物和脂质纳米颗粒 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5681702A (en) | 1994-08-30 | 1997-10-28 | Chiron Corporation | Reduction of nonspecific hybridization by using novel base-pairing schemes |
| EP2625189B1 (en) | 2010-10-01 | 2018-06-27 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| CA2824526C (en) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
| WO2013103659A1 (en) | 2012-01-04 | 2013-07-11 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Stabilizing rna by incorporating chain-terminating nucleosides at the 3'-terminus |
| WO2014093924A1 (en) | 2012-12-13 | 2014-06-19 | Moderna Therapeutics, Inc. | Modified nucleic acid molecules and uses thereof |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| US20160022840A1 (en) | 2013-03-09 | 2016-01-28 | Moderna Therapeutics, Inc. | Heterologous untranslated regions for mrna |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| CN105143456A (zh) | 2013-03-15 | 2015-12-09 | 不列颠哥伦比亚大学 | 用于转染的脂质纳米粒子和相关方法 |
| PL3386484T3 (pl) | 2015-12-10 | 2022-07-25 | Modernatx, Inc. | Kompozycje i sposoby dostarczania środków terapeutycznych |
| AU2017357758B2 (en) * | 2016-11-10 | 2023-11-16 | Translate Bio, Inc. | Improved process of preparing mRNA-loaded lipid nanoparticles |
| US20210137840A1 (en) * | 2018-04-25 | 2021-05-13 | Ethris Gmbh | Lipid-based formulations for the delivery of rna |
| JP7488193B2 (ja) * | 2018-05-24 | 2024-05-21 | トランスレイト バイオ， インコーポレイテッド | チオエステルカチオン性脂質 |
| CN118697900A (zh) * | 2019-01-31 | 2024-09-27 | 摩登纳特斯有限公司 | 制备脂质纳米颗粒的方法 |
| US20230181483A1 (en) * | 2019-07-08 | 2023-06-15 | Translate Bio, Inc. | Improved mrna-loaded lipid nanoparticles and processes of making the same |
-
2022
- 2022-07-25 WO PCT/US2022/038152 patent/WO2023009422A1/en not_active Ceased
- 2022-07-25 CN CN202280065046.4A patent/CN118019526A/zh active Pending
- 2022-07-25 JP JP2024504834A patent/JP2024527940A/ja active Pending
- 2022-07-25 TW TW111127850A patent/TW202320737A/zh unknown
- 2022-07-25 US US18/291,710 patent/US20240366522A1/en active Pending
- 2022-07-25 EP EP22754669.4A patent/EP4376815A1/en active Pending
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