JPWO2023076679A5 - - Google Patents

Info

Publication number
JPWO2023076679A5
JPWO2023076679A5 JP2024523819A JP2024523819A JPWO2023076679A5 JP WO2023076679 A5 JPWO2023076679 A5 JP WO2023076679A5 JP 2024523819 A JP2024523819 A JP 2024523819A JP 2024523819 A JP2024523819 A JP 2024523819A JP WO2023076679 A5 JPWO2023076679 A5 JP WO2023076679A5
Authority
JP
Japan
Prior art keywords
dihydro
benzyl
benzodioxin
dioxino
pyridin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024523819A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024542963A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/048434 external-priority patent/WO2023076679A1/en
Publication of JP2024542963A publication Critical patent/JP2024542963A/ja
Publication of JPWO2023076679A5 publication Critical patent/JPWO2023076679A5/ja
Pending legal-status Critical Current

Links

JP2024523819A 2021-11-01 2022-10-31 加齢関連疾患の予防及び治療のためのロイコトリエンa4加水分解酵素(lta4h)のベンゾジオキサン調節剤 Pending JP2024542963A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202163274222P 2021-11-01 2021-11-01
US63/274,222 2021-11-01
US202163293560P 2021-12-23 2021-12-23
US63/293,560 2021-12-23
US202263327496P 2022-04-05 2022-04-05
US63/327,496 2022-04-05
US202263342572P 2022-05-16 2022-05-16
US63/342,572 2022-05-16
PCT/US2022/048434 WO2023076679A1 (en) 2021-11-01 2022-10-31 Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

Publications (2)

Publication Number Publication Date
JP2024542963A JP2024542963A (ja) 2024-11-19
JPWO2023076679A5 true JPWO2023076679A5 (enExample) 2025-11-06

Family

ID=86158674

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024523819A Pending JP2024542963A (ja) 2021-11-01 2022-10-31 加齢関連疾患の予防及び治療のためのロイコトリエンa4加水分解酵素(lta4h)のベンゾジオキサン調節剤

Country Status (6)

Country Link
US (2) US11957671B2 (enExample)
EP (1) EP4426284A4 (enExample)
JP (1) JP2024542963A (enExample)
AU (1) AU2022376563A1 (enExample)
CA (1) CA3221177A1 (enExample)
WO (1) WO2023076679A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3097083A1 (en) * 2018-05-15 2019-11-21 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene a4 hydrolase

Family Cites Families (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6026099B2 (ja) 1977-09-21 1985-06-21 財団法人微生物化学研究会 ペプチド、その酸附加塩およびその製造法
AR227636A1 (es) 1978-11-25 1982-11-30 Nippon Kayaku Kk Procedimiento para producir acido treo-3-amino-2-hidroxibutanoil aminoacetico intermediarios para prepararlo y procedimiento para preparar los intermediarios
US4918092A (en) 1983-12-21 1990-04-17 Merck Frosst Canada, Inc. Leukotriene antagonists
US5120758A (en) 1991-02-08 1992-06-09 Ciba-Geigy Corporation Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors
DE4127849A1 (de) 1991-08-22 1993-02-25 Merck Patent Gmbh Benzodioxanderivate
US6506876B1 (en) 1994-10-11 2003-01-14 G.D. Searle & Co. LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use
US5585492A (en) 1994-10-11 1996-12-17 G. D. Searle & Co. LTA4 Hydrolase inhibitors
US5700816A (en) 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
DE19705450A1 (de) 1997-02-13 1998-08-20 Merck Patent Gmbh Bicyclische aromatische Aminosäuren
DE19821003A1 (de) 1998-05-11 1999-11-18 Dresden Arzneimittel Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CA2425280A1 (en) 2000-10-26 2002-05-02 Pfizer Products Inc. Pyrimidine-2,4,6-trione metalloproteinase inhibitors
AU2003277917A1 (en) 2002-09-30 2004-04-19 Bayer Healthcare Ag Splice-variants of the human leukotriene a-4 hydrolase
US20060019269A1 (en) 2002-10-17 2006-01-26 Decode Genetics, Inc. Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment
WO2005027886A2 (en) 2003-09-17 2005-03-31 Decode Genetics Ehf. Methods of preventing or treating recurrence of myocardial infarction
CA2509413C (en) 2002-12-20 2012-05-01 Glaxo Group Limited Benzazepine derivatives for the treatment of neurological disorders
JPWO2005011736A1 (ja) 2003-07-30 2006-09-14 株式会社 東北テクノアーチ アルツハイマー病の予防および/または治療剤
US7098222B2 (en) 2004-05-12 2006-08-29 Abbott Laboratories Bicyclic-substituted amines having cyclic-substituted monocyclic substituents
AP2362A (en) 2005-01-07 2012-02-08 Pfizer Prod Inc Heteroaromatic quinoline compounds and their use as PDE10 inhibitors.
JP2008536825A (ja) 2005-03-31 2008-09-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ フェニルおよびピリジルlta4hモジュレータ
JP4137081B2 (ja) 2005-04-06 2008-08-20 キヤノン株式会社 画像読取装置
CA2623348A1 (en) 2005-09-21 2007-04-12 Decode Genetics Ehf Biaryl substituted heterocycle inhibitors of lta4h for treating inflammation
CA2634699A1 (en) 2005-12-21 2007-06-28 Decode Genetics Ehf N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation
EP1968961A2 (en) 2005-12-21 2008-09-17 Decode Genetics EHF Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation
DK1976828T3 (en) 2005-12-29 2017-03-06 Celtaxsys Inc DIAMINE DERIVATIVES AS INhibitors of Leukotriene A4 HYDROLASE
AR063373A1 (es) 2006-10-24 2009-01-21 Wyeth Corp Derivados de benzodioxano y sus usos
US20090069444A1 (en) 2007-09-07 2009-03-12 The United States Of America, As Represented By Th E Secretary Of Agriculture Method to Ameliorate Oxidative Stress and Improve Working Memory Via Pterostilbene Administration
US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
WO2011032050A2 (en) 2009-09-11 2011-03-17 Trius Therapeutics, Inc. Gyrase inhibitors
GB2494787B (en) 2010-03-18 2018-10-17 Univ Hong Kong Sci & Tech Neuro-protective effects of adelostemma gracillimum and its isolated compounds
UA109290C2 (uk) 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
DK2686310T5 (en) 2011-03-14 2018-07-09 Boehringer Ingelheim Int Benzodioxan-INHIBITORERAFLEUKOTRIEN PRODUCTION
US9139567B2 (en) 2011-07-19 2015-09-22 Boehringer Ingelheim International Gmbh Arylpyrazole ethers as inhibitors of leukotriene A4 hydrolase
EP2822942B1 (en) 2012-03-06 2017-05-10 Boehringer Ingelheim International GmbH Benzodioxanes for inhibiting leukotriene production
CN104487435A (zh) 2012-03-06 2015-04-01 勃林格殷格翰国际有限公司 用于抑制白三烯生成的苯并二氧杂环己烷与其他活性剂的组合
US8680280B2 (en) 2012-04-02 2014-03-25 Boehringer Ingelheim International Gmbh Process for the manufacturing of CRR inhibitors
US20130261153A1 (en) 2012-04-03 2013-10-03 Boehringer Ingelheim International Gmbh Use of ccr3-inhibitors
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
US9403830B2 (en) 2012-07-17 2016-08-02 Boehringer Ingelheim International Gmbh Inhibitors of leukotriene production
JP6527851B2 (ja) 2013-03-12 2019-06-05 セルタクシス,インコーポレイテッド ロイコトリエンa4加水分解酵素を阻害する方法
EP2970309A4 (en) 2013-03-14 2016-11-09 Celtaxsys Inc INHIBITORS OF LEUCOTRIENE A4 HYDROLASE
JP2016523982A (ja) 2013-07-15 2016-08-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成の阻害剤
EP3022193B1 (en) 2013-07-15 2017-04-26 Boehringer Ingelheim International GmbH Inhibitors of leukotriene production
KR102368958B1 (ko) 2013-12-20 2022-02-28 노파르티스 아게 Lta4h 억제제로서의 헤테로아릴 부탄산 유도체
CN105891465A (zh) 2014-11-11 2016-08-24 中南大学 一种诊断日本血吸虫循环抗原的方法
TWI703138B (zh) 2015-02-12 2020-09-01 義大利商吉斯藥品公司 具有蕈毒鹼受體拮抗劑及β2腎上腺素受體促效劑活性之化合物
ES2900302T3 (es) 2016-04-28 2022-03-16 Alkahest Inc Fracciones de plasma como terapia para el crecimiento y la progresión del tumor
BR112019003172A2 (pt) 2016-08-18 2019-05-28 Alkahest Inc frações de plasma sanguíneo como tratamento para distúrbios cognitivos associados ao envelhecimento
CN109862888B (zh) 2016-09-28 2022-08-12 艾格尔峰生物制药有限公司 用于治疗非酒精性脂肪性肝炎的方法和药物组合物
EA039316B1 (ru) 2016-10-24 2022-01-12 Алкахест, Инк. Фракции плазмы крови в качестве лечения когнитивных расстройств, связанных со старением
CN110636844A (zh) 2017-04-05 2019-12-31 万能溶剂有限公司 使用ccr3-抑制剂治疗衰老相关损伤的方法及组合物
DK3615057T3 (da) 2017-04-26 2024-01-02 Alkahest Inc Doseringsskema til behandling af kognitive svækkelser med blodplasmaprodukter
WO2019075351A1 (en) 2017-10-13 2019-04-18 Alkahest, Inc. METHODS AND COMPOSITIONS FOR TREATING PRURIT, XEROSIS AND ASSOCIATED DISEASE USING CCR3 INHIBITORS
CA3097083A1 (en) * 2018-05-15 2019-11-21 Alkahest, Inc. Treatment of aging-associated disease with modulators of leukotriene a4 hydrolase

Similar Documents

Publication Publication Date Title
JP2015513552A5 (enExample)
JP2007516275A (ja) 認知増強および精神病性障害のための治療的組合せ
US20180125818A1 (en) Methods and compositions for treating schizophrenia
JP2021175759A (ja) 認知機能を改善するための方法および組成物
US20220226304A1 (en) Treatment of Aging-Associated Disease with Modulators of Leukotriene A4 Hydrolase
CN109662964A (zh) 用于改善认知功能的方法和组合物
CA2478227A1 (en) Therapy for psychoses combining an atypical antipsychotic and an mglu2/3 receptor agonist
JP6433482B2 (ja) 認知機能を改善するための方法および組成物
JP2009512677A (ja) ホスホジエステラーゼタイプiv阻害剤の組成物
US12496296B2 (en) Benzodioxane modulators of leukotriene A4 hydrolase (LTA4H) for prevention and treatment of aging-associated diseases
JPWO2023076679A5 (enExample)
JP2002338497A (ja) 抑うつ及び不安のための併合療法
US20100004215A1 (en) Compositions of phosphodiesterase type iv inhibitors
CN1091370C (zh) 舒布硫胺在制备用于治疗某些精神运动性和心理智力性疾病的药物组合物中的用途
JP2009263234A (ja) ホスホジエステラーゼタイプiv阻害剤の組成物
CN117729916A (zh) 用于预防和治疗衰老相关疾病的白三烯a4水解酶(lta4h)的苯并二噁烷调节剂
HK40044297A (en) Treatment of aging-associated disease with modulators of leukotriene a4 hydrolase
EP2111861A1 (en) Compositions of phosphodiesterase type IV inhibitors
HK1138179A (en) Compositions of phosphodiesterase type iv inhibitors