JP2015513552A5 - - Google Patents
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- Publication number
- JP2015513552A5 JP2015513552A5 JP2014560334A JP2014560334A JP2015513552A5 JP 2015513552 A5 JP2015513552 A5 JP 2015513552A5 JP 2014560334 A JP2014560334 A JP 2014560334A JP 2014560334 A JP2014560334 A JP 2014560334A JP 2015513552 A5 JP2015513552 A5 JP 2015513552A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydro
- benzyl
- benzodioxin
- dioxino
- pyridin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261607149P | 2012-03-06 | 2012-03-06 | |
| US61/607,149 | 2012-03-06 | ||
| PCT/EP2013/054381 WO2013131901A1 (en) | 2012-03-06 | 2013-03-05 | Benzodioxanes in combination with other actives for inhibiting leukotriene production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015513552A JP2015513552A (ja) | 2015-05-14 |
| JP2015513552A5 true JP2015513552A5 (enExample) | 2016-04-21 |
| JP6080226B2 JP6080226B2 (ja) | 2017-02-15 |
Family
ID=47833062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014560334A Active JP6080226B2 (ja) | 2012-03-06 | 2013-03-05 | 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US9662339B2 (enExample) |
| EP (1) | EP2822941B1 (enExample) |
| JP (1) | JP6080226B2 (enExample) |
| KR (1) | KR20140138851A (enExample) |
| CN (1) | CN104487435A (enExample) |
| AR (1) | AR090259A1 (enExample) |
| AU (1) | AU2013229560A1 (enExample) |
| CA (1) | CA2866471A1 (enExample) |
| CL (1) | CL2014002326A1 (enExample) |
| EA (1) | EA201400976A1 (enExample) |
| MX (1) | MX2014010563A (enExample) |
| NZ (1) | NZ628587A (enExample) |
| PH (1) | PH12014501967A1 (enExample) |
| TW (1) | TW201350475A (enExample) |
| UY (1) | UY34661A (enExample) |
| WO (1) | WO2013131901A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX355309B (es) | 2011-03-14 | 2018-04-16 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno. |
| WO2013012844A1 (en) | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| JP6080226B2 (ja) | 2012-03-06 | 2017-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン |
| AR091315A1 (es) | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
| US9255154B2 (en) | 2012-05-08 | 2016-02-09 | Alderbio Holdings, Llc | Anti-PCSK9 antibodies and use thereof |
| US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| BR112015024116A2 (pt) | 2013-03-27 | 2017-10-24 | Hoffmann La Roche | marcadores genéticos para prever capacidade de resposta à terapia |
| WO2015009609A1 (en) | 2013-07-15 | 2015-01-22 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
| EP3022194B1 (en) | 2013-07-15 | 2017-05-17 | Boehringer Ingelheim International GmbH | Inhibitors of leukotriene production |
| JP6854752B2 (ja) | 2014-07-30 | 2021-04-07 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｈｄｌ上昇剤又はｈｄｌ模倣剤を用いた治療に対する応答性を予測するための遺伝マーカー |
| US10968193B2 (en) * | 2014-08-08 | 2021-04-06 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| CN104181252B (zh) * | 2014-09-01 | 2015-12-02 | 广东东阳光药业有限公司 | 一种分离检测安塞曲匹及其异构体的方法 |
| CN105748469B (zh) * | 2016-02-24 | 2019-07-23 | 长沙佰顺生物科技有限公司 | 一种安塞曲匹辛伐他汀药物组合物 |
| JP6832342B2 (ja) * | 2016-03-31 | 2021-02-24 | 武田薬品工業株式会社 | 複素環化合物 |
| EP4196478A1 (en) | 2020-08-14 | 2023-06-21 | Novartis AG | Heteroaryl substituted spiropiperidinyl derivatives and pharmaceutical uses thereof |
| CN112076189B (zh) * | 2020-09-23 | 2021-11-12 | 唐怡庭 | 一种酰胺化合物在制备治疗脓毒症药物中的应用 |
| AU2022376563A1 (en) | 2021-11-01 | 2023-12-07 | Alkahest, Inc. | Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US498770A (en) * | 1893-06-06 | Electrolytic apparatus | ||
| US4918092A (en) * | 1983-12-21 | 1990-04-17 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
| US5120758A (en) * | 1991-02-08 | 1992-06-09 | Ciba-Geigy Corporation | Certain benzodioxole, benzodioxane and benzodioxepin derivatives useful as 5-lipoxygenase inhibitors |
| DE4127849A1 (de) | 1991-08-22 | 1993-02-25 | Merck Patent Gmbh | Benzodioxanderivate |
| US5585492A (en) | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6506876B1 (en) | 1994-10-11 | 2003-01-14 | G.D. Searle & Co. | LTA4 hydrolase inhibitor pharmaceutical compositions and methods of use |
| DE19705450A1 (de) | 1997-02-13 | 1998-08-20 | Merck Patent Gmbh | Bicyclische aromatische Aminosäuren |
| DE19821003A1 (de) | 1998-05-11 | 1999-11-18 | Dresden Arzneimittel | Neue 1,2,5-trisubstituierte 1,2-dihydro-indazol-3-one mit antiasthmatischer, antiallergischer, entzündungshemmender, immunmodulierender und neuroprotektiver Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EE200300195A (et) | 2000-10-26 | 2003-10-15 | Pfizer Products Inc. | Pürimidiin-2,4,6-trioonmetalloproteinaasi inhibiitorid |
| US20060019269A1 (en) * | 2002-10-17 | 2006-01-26 | Decode Genetics, Inc. | Susceptibility gene for myocardial infarction, stroke, and PAOD, methods of treatment |
| ATE441417T1 (de) | 2002-12-20 | 2009-09-15 | Glaxo Group Ltd | Benzoädüazepinderivate für die behandlung von neurologischen krankheiten |
| US7098222B2 (en) | 2004-05-12 | 2006-08-29 | Abbott Laboratories | Bicyclic-substituted amines having cyclic-substituted monocyclic substituents |
| ATE472543T1 (de) | 2005-01-07 | 2010-07-15 | Pfizer Prod Inc | Heteroaromatische chinolinverbindungen und deren verwendung als pde10-inhibitoren |
| JP2008536825A (ja) | 2005-03-31 | 2008-09-11 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | フェニルおよびピリジルｌｔａ４ｈモジュレータ |
| US7402684B2 (en) | 2005-09-21 | 2008-07-22 | Decode Genectics Ehf. | Biaryl substituted heterocycle inhibitors of LTA4H for treating inflammation |
| WO2007078335A2 (en) | 2005-12-21 | 2007-07-12 | Decode Genetics, Ehf. | Biaryl nitrogen heterocycle inhibitors of lta4h for treating inflammation |
| WO2007073405A1 (en) | 2005-12-21 | 2007-06-28 | Decode Genetics Ehf | N-linked aryl heteroaryl inhibitors of lta4h for treating inflammation |
| WO2008052086A1 (en) | 2006-10-24 | 2008-05-02 | Wyeth | Benzodioxane derivatives and uses thereof |
| EP2336125B1 (en) | 2008-04-11 | 2013-01-09 | Janssen Pharmaceutica N.V. | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase |
| CA2756542C (en) | 2009-04-08 | 2017-08-22 | Actelion Pharmaceuticals Ltd | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines |
| WO2011032050A2 (en) | 2009-09-11 | 2011-03-17 | Trius Therapeutics, Inc. | Gyrase inhibitors |
| GB2494787B (en) | 2010-03-18 | 2018-10-17 | Univ Hong Kong Sci & Tech | Neuro-protective effects of adelostemma gracillimum and its isolated compounds |
| MX355309B (es) * | 2011-03-14 | 2018-04-16 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno. |
| WO2013012844A1 (en) | 2011-07-19 | 2013-01-24 | Boehringer Ingelheim International Gmbh | Arylpyrazole ethers as inhibitors of leukotriene a4 hydrolase |
| AR091315A1 (es) | 2012-03-06 | 2015-01-28 | Boehringer Ingelheim Int | Inhibidores de benzodioxano de la produccion de leucotrieno |
| JP6080226B2 (ja) | 2012-03-06 | 2017-02-15 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 他の活性物質と組み合わせたロイコトリエン産生阻害用ベンゾジオキサン |
| US9403830B2 (en) | 2012-07-17 | 2016-08-02 | Boehringer Ingelheim International Gmbh | Inhibitors of leukotriene production |
-
2013
- 2013-03-05 JP JP2014560334A patent/JP6080226B2/ja active Active
- 2013-03-05 NZ NZ628587A patent/NZ628587A/en not_active IP Right Cessation
- 2013-03-05 CA CA2866471A patent/CA2866471A1/en not_active Abandoned
- 2013-03-05 EP EP13707858.0A patent/EP2822941B1/en active Active
- 2013-03-05 CN CN201380022189.8A patent/CN104487435A/zh active Pending
- 2013-03-05 US US13/785,097 patent/US9662339B2/en active Active
- 2013-03-05 EA EA201400976A patent/EA201400976A1/ru unknown
- 2013-03-05 AR ARP130100729A patent/AR090259A1/es unknown
- 2013-03-05 WO PCT/EP2013/054381 patent/WO2013131901A1/en not_active Ceased
- 2013-03-05 TW TW102107706A patent/TW201350475A/zh unknown
- 2013-03-05 MX MX2014010563A patent/MX2014010563A/es unknown
- 2013-03-05 AU AU2013229560A patent/AU2013229560A1/en not_active Abandoned
- 2013-03-05 KR KR1020147027959A patent/KR20140138851A/ko not_active Withdrawn
- 2013-03-06 UY UY0001034661A patent/UY34661A/es unknown
-
2014
- 2014-09-01 CL CL2014002326A patent/CL2014002326A1/es unknown
- 2014-09-03 PH PH12014501967A patent/PH12014501967A1/en unknown
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