JPWO2023074847A5 - - Google Patents
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- Publication number
- JPWO2023074847A5 JPWO2023074847A5 JP2023556670A JP2023556670A JPWO2023074847A5 JP WO2023074847 A5 JPWO2023074847 A5 JP WO2023074847A5 JP 2023556670 A JP2023556670 A JP 2023556670A JP 2023556670 A JP2023556670 A JP 2023556670A JP WO2023074847 A5 JPWO2023074847 A5 JP WO2023074847A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- ring
- aliphatic heterocyclic
- represented
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001072 heteroaryl group Chemical group 0.000 claims 125
- 125000002950 monocyclic group Chemical group 0.000 claims 86
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 84
- 125000001424 substituent group Chemical group 0.000 claims 61
- 125000003118 aryl group Chemical group 0.000 claims 58
- 125000000217 alkyl group Chemical group 0.000 claims 56
- 125000005843 halogen group Chemical group 0.000 claims 54
- -1 azolidinyl Chemical group 0.000 claims 53
- 125000001931 aliphatic group Chemical group 0.000 claims 51
- 125000000623 heterocyclic group Chemical group 0.000 claims 51
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 48
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 42
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 42
- 125000005842 heteroatom Chemical group 0.000 claims 42
- 229910052757 nitrogen Inorganic materials 0.000 claims 42
- 229910052760 oxygen Inorganic materials 0.000 claims 42
- 239000001301 oxygen Substances 0.000 claims 42
- 229910052717 sulfur Inorganic materials 0.000 claims 42
- 239000011593 sulfur Substances 0.000 claims 42
- 150000001875 compounds Chemical class 0.000 claims 38
- 150000003839 salts Chemical class 0.000 claims 37
- 125000000753 cycloalkyl group Chemical group 0.000 claims 36
- 125000001188 haloalkyl group Chemical group 0.000 claims 35
- 125000003545 alkoxy group Chemical group 0.000 claims 34
- 125000004093 cyano group Chemical group *C#N 0.000 claims 23
- 125000003107 substituted aryl group Chemical group 0.000 claims 23
- 125000004043 oxo group Chemical group O=* 0.000 claims 20
- 125000003277 amino group Chemical group 0.000 claims 17
- 125000004414 alkyl thio group Chemical group 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
- 125000002252 acyl group Chemical group 0.000 claims 13
- 125000002947 alkylene group Chemical group 0.000 claims 13
- 125000000000 cycloalkoxy group Chemical group 0.000 claims 12
- 125000004438 haloalkoxy group Chemical group 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 11
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 10
- 125000004076 pyridyl group Chemical group 0.000 claims 9
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 8
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 7
- 125000004104 aryloxy group Chemical group 0.000 claims 7
- 125000003725 azepanyl group Chemical group 0.000 claims 7
- 125000005961 oxazepanyl group Chemical group 0.000 claims 7
- 125000005959 diazepanyl group Chemical group 0.000 claims 6
- 125000002883 imidazolyl group Chemical group 0.000 claims 6
- 125000003226 pyrazolyl group Chemical group 0.000 claims 6
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 6
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000001425 triazolyl group Chemical group 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 5
- 125000006310 cycloalkyl amino group Chemical group 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000001786 isothiazolyl group Chemical group 0.000 claims 5
- 125000000842 isoxazolyl group Chemical group 0.000 claims 5
- 125000002971 oxazolyl group Chemical group 0.000 claims 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 5
- 125000000168 pyrrolyl group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000002541 furyl group Chemical group 0.000 claims 4
- 125000002098 pyridazinyl group Chemical group 0.000 claims 4
- 125000003831 tetrazolyl group Chemical group 0.000 claims 4
- 125000006407 thiazinanyl group Chemical group 0.000 claims 4
- 125000004305 thiazinyl group Chemical group S1NC(=CC=C1)* 0.000 claims 4
- 125000004306 triazinyl group Chemical group 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 3
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000000532 dioxanyl group Chemical group 0.000 claims 2
- 125000000160 oxazolidinyl group Chemical group 0.000 claims 2
- 125000003551 oxepanyl group Chemical group 0.000 claims 2
- 125000003566 oxetanyl group Chemical group 0.000 claims 2
- 125000005475 oxolanyl group Chemical group 0.000 claims 2
- 125000005415 substituted alkoxy group Chemical group 0.000 claims 2
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 2
- 125000005458 thianyl group Chemical group 0.000 claims 2
- 125000001984 thiazolidinyl group Chemical group 0.000 claims 2
- 125000001583 thiepanyl group Chemical group 0.000 claims 2
- 125000001166 thiolanyl group Chemical group 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 1
- 125000005334 azaindolyl group Chemical group N1N=C(C2=CC=CC=C12)* 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005945 imidazopyridyl group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021177933 | 2021-10-29 | ||
| PCT/JP2022/040370 WO2023074847A1 (ja) | 2021-10-29 | 2022-10-28 | 新規スピロ化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023074847A1 JPWO2023074847A1 (https=) | 2023-05-04 |
| JPWO2023074847A5 true JPWO2023074847A5 (https=) | 2024-07-18 |
Family
ID=86159495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023556670A Pending JPWO2023074847A1 (https=) | 2021-10-29 | 2022-10-28 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4438594A1 (https=) |
| JP (1) | JPWO2023074847A1 (https=) |
| KR (1) | KR20240091009A (https=) |
| CN (1) | CN118176179A (https=) |
| AR (1) | AR127489A1 (https=) |
| AU (1) | AU2022379243A1 (https=) |
| CA (1) | CA3236538A1 (https=) |
| IL (1) | IL312247A (https=) |
| MX (1) | MX2024005187A (https=) |
| TW (1) | TW202325272A (https=) |
| WO (1) | WO2023074847A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4558481A1 (en) * | 2022-07-22 | 2025-05-28 | Biogen MA Inc. | Emopamil-binding protein inhibitors and uses thereof |
| CN117603226B (zh) * | 2023-11-27 | 2025-08-01 | 成都大学 | 一种吡唑并氮氧双杂卓类化合物及其制备方法和用途 |
| CN120398919B (zh) * | 2024-02-01 | 2026-04-07 | 福石生物科技(合肥)有限公司 | 作为wrn抑制剂的螺环衍生物及其应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE20000240A1 (en) | 2000-02-17 | 2003-03-05 | Trinity College Dublin | TRH-like peptide derivatives |
| KR100557268B1 (ko) | 2000-08-31 | 2006-03-07 | 시오노기세이야쿠가부시키가이샤 | 파킨슨씨병 치료제 |
| US7713935B2 (en) | 2004-10-01 | 2010-05-11 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Compounds that modulate TRH actions |
| IE20060253A1 (en) | 2006-03-31 | 2007-11-14 | Trinity College Dublin | Methods for modulating the levels and effects of thyrotropin-releasing hormone(trh)and trh-related peptides |
| TW202204333A (zh) * | 2020-04-08 | 2022-02-01 | 美商阿吉歐斯製藥公司 | Menin抑制劑及治療癌症之使用方法 |
| AU2021333760A1 (en) * | 2020-08-26 | 2023-04-06 | Nalo Therapeutics | Modulators of Myc family proto-oncogene protein |
| WO2022140472A1 (en) * | 2020-12-22 | 2022-06-30 | Nikang Therapeutics, Inc. | Compounds for degrading cyclin-dependent kinase 2 via ubiquitin proteosome pathway |
| US20220363662A1 (en) * | 2021-04-20 | 2022-11-17 | Integral Biosciences Privated Limited | Compounds as lxr agonists |
-
2022
- 2022-10-28 IL IL312247A patent/IL312247A/en unknown
- 2022-10-28 JP JP2023556670A patent/JPWO2023074847A1/ja active Pending
- 2022-10-28 KR KR1020247017508A patent/KR20240091009A/ko active Pending
- 2022-10-28 CN CN202280072520.6A patent/CN118176179A/zh active Pending
- 2022-10-28 AR ARP220102936A patent/AR127489A1/es not_active Application Discontinuation
- 2022-10-28 WO PCT/JP2022/040370 patent/WO2023074847A1/ja not_active Ceased
- 2022-10-28 MX MX2024005187A patent/MX2024005187A/es unknown
- 2022-10-28 CA CA3236538A patent/CA3236538A1/en active Pending
- 2022-10-28 EP EP22887172.9A patent/EP4438594A1/en not_active Withdrawn
- 2022-10-28 AU AU2022379243A patent/AU2022379243A1/en active Pending
- 2022-10-28 TW TW111141195A patent/TW202325272A/zh unknown
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