CN118176179A - 新颖的螺环化合物 - Google Patents
新颖的螺环化合物 Download PDFInfo
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- CN118176179A CN118176179A CN202280072520.6A CN202280072520A CN118176179A CN 118176179 A CN118176179 A CN 118176179A CN 202280072520 A CN202280072520 A CN 202280072520A CN 118176179 A CN118176179 A CN 118176179A
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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| JP2021-177933 | 2021-10-29 | ||
| JP2021177933 | 2021-10-29 | ||
| PCT/JP2022/040370 WO2023074847A1 (ja) | 2021-10-29 | 2022-10-28 | 新規スピロ化合物 |
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| CN117603226B (zh) * | 2023-11-27 | 2025-08-01 | 成都大学 | 一种吡唑并氮氧双杂卓类化合物及其制备方法和用途 |
| CN120398919B (zh) * | 2024-02-01 | 2026-04-07 | 福石生物科技(合肥)有限公司 | 作为wrn抑制剂的螺环衍生物及其应用 |
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| KR20050105290A (ko) | 2000-08-31 | 2005-11-03 | 시오노기세이야쿠가부시키가이샤 | 파킨슨씨병 치료제 |
| AU2005290844B2 (en) | 2004-10-01 | 2011-09-29 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin | Compounds that Modulate TRH Actions and Inhibit the TRH-Degrading Enzyme |
| IE20060253A1 (en) | 2006-03-31 | 2007-11-14 | Trinity College Dublin | Methods for modulating the levels and effects of thyrotropin-releasing hormone(trh)and trh-related peptides |
| TW202204333A (zh) * | 2020-04-08 | 2022-02-01 | 美商阿吉歐斯製藥公司 | Menin抑制劑及治療癌症之使用方法 |
| CA3190539A1 (en) * | 2020-08-26 | 2022-03-03 | William Greenlee | Modulators of myc family proto-oncogene protein |
| WO2022140472A1 (en) * | 2020-12-22 | 2022-06-30 | Nikang Therapeutics, Inc. | Compounds for degrading cyclin-dependent kinase 2 via ubiquitin proteosome pathway |
| WO2022224166A1 (en) * | 2021-04-20 | 2022-10-27 | Integral Biosciences Private Limited | Compounds as lxr agonists |
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