KR20240091009A - 신규 스피로 화합물 - Google Patents

신규 스피로 화합물 Download PDF

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KR20240091009A
KR20240091009A KR1020247017508A KR20247017508A KR20240091009A KR 20240091009 A KR20240091009 A KR 20240091009A KR 1020247017508 A KR1020247017508 A KR 1020247017508A KR 20247017508 A KR20247017508 A KR 20247017508A KR 20240091009 A KR20240091009 A KR 20240091009A
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South Korea
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group
ring
optionally substituted
substituted
represented
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Korean (ko)
Inventor
노리미츠 하야시
마사야 이쿠보
아키라 나카오
신고 오가타
미나미 나가오카
겐지 후쿠나가
렌타로우 간노
다카히로 야마다
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미쓰비시 타나베 파마 코퍼레이션
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Publication of KR20240091009A publication Critical patent/KR20240091009A/ko
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    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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WO2006038206A2 (en) 2004-10-01 2006-04-13 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Compounds that modulate trh actions and inhibit the trh-degrading enzyme
WO2007113784A2 (en) 2006-03-31 2007-10-11 The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Methods for modulating the levels and effects of thyrotropin-releasing hormone (trh) and trh-related petides

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