JPWO2023064530A5 - - Google Patents

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Publication number
JPWO2023064530A5
JPWO2023064530A5 JP2024522206A JP2024522206A JPWO2023064530A5 JP WO2023064530 A5 JPWO2023064530 A5 JP WO2023064530A5 JP 2024522206 A JP2024522206 A JP 2024522206A JP 2024522206 A JP2024522206 A JP 2024522206A JP WO2023064530 A5 JPWO2023064530 A5 JP WO2023064530A5
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JP
Japan
Prior art keywords
dsrna agent
pharmaceutically acceptable
acceptable salt
linker
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024522206A
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English (en)
Japanese (ja)
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JP2024539629A5 (https=
JP2024539629A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/046668 external-priority patent/WO2023064530A1/en
Publication of JP2024539629A publication Critical patent/JP2024539629A/ja
Publication of JP2024539629A5 publication Critical patent/JP2024539629A5/ja
Publication of JPWO2023064530A5 publication Critical patent/JPWO2023064530A5/ja
Pending legal-status Critical Current

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JP2024522206A 2021-10-15 2022-10-14 肝外デリバリーｉＲＮＡ組成物およびその使用方法 Pending JP2024539629A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163255984P 2021-10-15 2021-10-15
US63/255,984 2021-10-15
PCT/US2022/046668 WO2023064530A1 (en) 2021-10-15 2022-10-14 Extra-hepatic delivery irna compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2024539629A JP2024539629A (ja) 2024-10-29
JP2024539629A5 JP2024539629A5 (https=) 2025-10-22
JPWO2023064530A5 true JPWO2023064530A5 (https=) 2025-10-22

Family

ID=84360072

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024522206A Pending JP2024539629A (ja) 2021-10-15 2022-10-14 肝外デリバリーｉＲＮＡ組成物およびその使用方法

Country Status (10)

Country Link
US (1) US20240360455A1 (https=)
EP (1) EP4416284A1 (https=)
JP (1) JP2024539629A (https=)
KR (1) KR20240101590A9 (https=)
CN (1) CN118369427A (https=)
AU (1) AU2022364838A1 (https=)
CA (1) CA3234887A1 (https=)
IL (1) IL311864A (https=)
MX (1) MX2024004437A (https=)
WO (1) WO2023064530A1 (https=)

Families Citing this family (8)

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WO2025007063A1 (en) 2023-06-30 2025-01-02 Avidity Biosciences, Inc. Compositions and methods of using pln-targeting antibody-oligonucleotide conjugates
WO2025064660A2 (en) 2023-09-21 2025-03-27 Alnylam Pharmaceuticals, Inc. Activin a receptor type 1c (acvr1c) irna compositions and methods of use thereof
WO2025073871A1 (en) 2023-10-03 2025-04-10 Bicycletx Limited Bicyclic peptide ligand complexes specific for tfr1
WO2025259743A1 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dual conjugate compounds for extrahepatic delivery
WO2025259747A2 (en) 2024-06-12 2025-12-18 Alnylam Pharmaceuticals, Inc. Dystrophy myotonic protein kinase (dmpk) irna compositions and methods of use thereof
WO2026007966A1 (zh) * 2024-07-01 2026-01-08 武汉人福创新药物研发中心有限公司 抑制INHBE基因表达的siRNA、偶联物及其应用
CN119242629B (zh) * 2024-08-01 2025-08-01 北京尧景基因技术有限公司 抑制PLN基因表达的siRNA及其缀合物和应用
WO2026046355A1 (zh) * 2024-08-31 2026-03-05 齐鲁制药有限公司 dsRNA分子、药物组合物及其在肝外递送中的应用

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