JPWO2022266237A5 - - Google Patents

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Publication number
JPWO2022266237A5
JPWO2022266237A5 JP2023577845A JP2023577845A JPWO2022266237A5 JP WO2022266237 A5 JPWO2022266237 A5 JP WO2022266237A5 JP 2023577845 A JP2023577845 A JP 2023577845A JP 2023577845 A JP2023577845 A JP 2023577845A JP WO2022266237 A5 JPWO2022266237 A5 JP WO2022266237A5
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JP
Japan
Prior art keywords
optionally substituted
prodrug
alkyl
independently selected
guanine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023577845A
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English (en)
Japanese (ja)
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JP2024522783A5 (https=
JP2024522783A (ja
Publication date
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Priority claimed from PCT/US2022/033654 external-priority patent/WO2022266237A1/en
Publication of JP2024522783A publication Critical patent/JP2024522783A/ja
Publication of JP2024522783A5 publication Critical patent/JP2024522783A5/ja
Publication of JPWO2022266237A5 publication Critical patent/JPWO2022266237A5/ja
Pending legal-status Critical Current

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JP2023577845A 2021-06-18 2022-06-15 不均衡なヌクレオチドプールによって引き起こされたミトコンドリア疾患を治療するためのデオキシヌクレオシドのプロドラッグ Pending JP2024522783A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163212468P 2021-06-18 2021-06-18
US63/212,468 2021-06-18
PCT/US2022/033654 WO2022266237A1 (en) 2021-06-18 2022-06-15 Prodrugs of deoxynucleosides for treatment of mitochondrial diseases caused by unbalanced nucleotide pools

Publications (3)

Publication Number Publication Date
JP2024522783A JP2024522783A (ja) 2024-06-21
JP2024522783A5 JP2024522783A5 (https=) 2025-06-24
JPWO2022266237A5 true JPWO2022266237A5 (https=) 2025-06-24

Family

ID=84526701

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023577845A Pending JP2024522783A (ja) 2021-06-18 2022-06-15 不均衡なヌクレオチドプールによって引き起こされたミトコンドリア疾患を治療するためのデオキシヌクレオシドのプロドラッグ

Country Status (9)

Country Link
US (2) US20230000890A1 (https=)
EP (1) EP4355336A4 (https=)
JP (1) JP2024522783A (https=)
CN (1) CN117500510A (https=)
AU (1) AU2022291783A1 (https=)
CA (1) CA3222484A1 (https=)
IL (1) IL309421A (https=)
MX (1) MX2023014944A (https=)
WO (1) WO2022266237A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4313068A4 (en) * 2021-03-26 2024-12-25 UCB Biosciences, Inc. Aqueous solutions containing purines and pyrimidines and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10292996B2 (en) * 2015-03-26 2019-05-21 The Trustees Of Columbia University In The City Of New York Deoxyribonucleoside monophospate bypass therapy for mitochondrial DNA depletion syndrome
JP6599484B2 (ja) * 2015-06-17 2019-10-30 ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク ミトコンドリアｄｎａ枯渇症候群を含む不均衡なヌクレオチドプールによって引き起こされる疾患のためのデオキシヌクレオシド療法
US10745435B2 (en) * 2015-11-16 2020-08-18 Cerecor, Inc. Nucleic acid prodrugs
US11628182B2 (en) * 2018-04-12 2023-04-18 Zogenix Mds, Inc. Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools

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