JP2021521210A5 - - Google Patents
Info
- Publication number
- JP2021521210A5 JP2021521210A5 JP2020556284A JP2020556284A JP2021521210A5 JP 2021521210 A5 JP2021521210 A5 JP 2021521210A5 JP 2020556284 A JP2020556284 A JP 2020556284A JP 2020556284 A JP2020556284 A JP 2020556284A JP 2021521210 A5 JP2021521210 A5 JP 2021521210A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- pharmaceutical composition
- alkyl
- composition according
- prodrug
- Prior art date
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023215758A JP7784411B2 (ja) | 2018-04-12 | 2023-12-21 | 不均衡なヌクレオチドプールによって引き起こされた疾患を治療するためのデオキシヌクレオシドのプロドラッグ |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862656861P | 2018-04-12 | 2018-04-12 | |
| US62/656,861 | 2018-04-12 | ||
| PCT/US2019/027364 WO2019200340A1 (en) | 2018-04-12 | 2019-04-12 | Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023215758A Division JP7784411B2 (ja) | 2018-04-12 | 2023-12-21 | 不均衡なヌクレオチドプールによって引き起こされた疾患を治療するためのデオキシヌクレオシドのプロドラッグ |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2021521210A JP2021521210A (ja) | 2021-08-26 |
| JP2021521210A5 true JP2021521210A5 (https=) | 2022-04-19 |
| JPWO2019200340A5 JPWO2019200340A5 (https=) | 2022-04-19 |
| JP7620781B2 JP7620781B2 (ja) | 2025-01-24 |
Family
ID=68163825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020556284A Active JP7620781B2 (ja) | 2018-04-12 | 2019-04-12 | 不均衡なヌクレオチドプールによって引き起こされた疾患を治療するためのデオキシヌクレオシドのプロドラッグ |
| JP2023215758A Active JP7784411B2 (ja) | 2018-04-12 | 2023-12-21 | 不均衡なヌクレオチドプールによって引き起こされた疾患を治療するためのデオキシヌクレオシドのプロドラッグ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023215758A Active JP7784411B2 (ja) | 2018-04-12 | 2023-12-21 | 不均衡なヌクレオチドプールによって引き起こされた疾患を治療するためのデオキシヌクレオシドのプロドラッグ |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US11628182B2 (https=) |
| EP (1) | EP3773603A4 (https=) |
| JP (2) | JP7620781B2 (https=) |
| CN (1) | CN112384228A (https=) |
| AU (2) | AU2019253023B2 (https=) |
| BR (1) | BR112020020804A2 (https=) |
| CA (1) | CA3096264A1 (https=) |
| IL (1) | IL277725B2 (https=) |
| MX (1) | MX2020010667A (https=) |
| WO (1) | WO2019200340A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11628182B2 (en) | 2018-04-12 | 2023-04-18 | Zogenix Mds, Inc. | Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools |
| EP4313068A4 (en) * | 2021-03-26 | 2024-12-25 | UCB Biosciences, Inc. | Aqueous solutions containing purines and pyrimidines and uses thereof |
| US20230000890A1 (en) * | 2021-06-18 | 2023-01-05 | Zogenix Mds, Inc. | Prodrugs of Deoxynucleosides for Treatment of Mitochondrial Diseases Caused by Unbalanced Nucleotide Pools |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| EP0753525A4 (en) | 1994-03-31 | 1997-09-03 | Nippon Shinyaku Co Ltd | CYCLIC NUCLEOTIDE DERIVATIVES |
| US6875751B2 (en) | 2000-06-15 | 2005-04-05 | Idenix Pharmaceuticals, Inc. | 3′-prodrugs of 2′-deoxy-β-L-nucleosides |
| MY141594A (en) | 2000-06-15 | 2010-05-14 | Novirio Pharmaceuticals Ltd | 3'-PRODRUGS OF 2'-DEOXY-ß-L-NUCLEOSIDES |
| WO2002057425A2 (en) | 2001-01-22 | 2002-07-25 | Merck & Co., Inc. | Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase |
| US10292996B2 (en) | 2015-03-26 | 2019-05-21 | The Trustees Of Columbia University In The City Of New York | Deoxyribonucleoside monophospate bypass therapy for mitochondrial DNA depletion syndrome |
| JP6599484B2 (ja) | 2015-06-17 | 2019-10-30 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | ミトコンドリアｄｎａ枯渇症候群を含む不均衡なヌクレオチドプールによって引き起こされる疾患のためのデオキシヌクレオシド療法 |
| US10745435B2 (en) * | 2015-11-16 | 2020-08-18 | Cerecor, Inc. | Nucleic acid prodrugs |
| BR112018076913A2 (pt) | 2016-06-24 | 2019-04-02 | Emory University | fosforamidatos para o tratamento do vírus da hepatite b |
| US11628182B2 (en) | 2018-04-12 | 2023-04-18 | Zogenix Mds, Inc. | Prodrugs of deoxynucleosides for treatment of diseases cased by unbalanced nucleotide pools |
-
2019
- 2019-04-12 US US17/046,865 patent/US11628182B2/en active Active
- 2019-04-12 JP JP2020556284A patent/JP7620781B2/ja active Active
- 2019-04-12 AU AU2019253023A patent/AU2019253023B2/en active Active
- 2019-04-12 MX MX2020010667A patent/MX2020010667A/es unknown
- 2019-04-12 EP EP19784627.2A patent/EP3773603A4/en active Pending
- 2019-04-12 BR BR112020020804-3A patent/BR112020020804A2/pt unknown
- 2019-04-12 CA CA3096264A patent/CA3096264A1/en active Pending
- 2019-04-12 IL IL277725A patent/IL277725B2/en unknown
- 2019-04-12 WO PCT/US2019/027364 patent/WO2019200340A1/en not_active Ceased
- 2019-04-12 CN CN201980038898.2A patent/CN112384228A/zh active Pending
-
2023
- 2023-02-10 US US18/167,317 patent/US20230181617A1/en active Pending
- 2023-02-10 US US18/167,308 patent/US12419901B2/en active Active
- 2023-12-21 JP JP2023215758A patent/JP7784411B2/ja active Active
-
2025
- 2025-03-14 AU AU2025201857A patent/AU2025201857A1/en active Pending
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