JPWO2022254362A5 - - Google Patents
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- Publication number
- JPWO2022254362A5 JPWO2022254362A5 JP2023574412A JP2023574412A JPWO2022254362A5 JP WO2022254362 A5 JPWO2022254362 A5 JP WO2022254362A5 JP 2023574412 A JP2023574412 A JP 2023574412A JP 2023574412 A JP2023574412 A JP 2023574412A JP WO2022254362 A5 JPWO2022254362 A5 JP WO2022254362A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- independently selected
- alkyl
- pharma
- solvate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163196422P | 2021-06-03 | 2021-06-03 | |
| US63/196,422 | 2021-06-03 | ||
| PCT/IB2022/055131 WO2022254362A1 (en) | 2021-06-03 | 2022-06-01 | 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and medical uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024520654A JP2024520654A (ja) | 2024-05-24 |
| JPWO2022254362A5 true JPWO2022254362A5 (enExample) | 2025-05-30 |
Family
ID=82115547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574412A Pending JP2024520654A (ja) | 2021-06-03 | 2022-06-01 | ３－（１－オキソイソインドリン－２－イル）ピペリジン－２，６－ジオン誘導体及びその医療用使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US12103919B2 (enExample) |
| EP (1) | EP4347580A1 (enExample) |
| JP (1) | JP2024520654A (enExample) |
| KR (1) | KR20240013812A (enExample) |
| CN (1) | CN117062811A (enExample) |
| AR (1) | AR126052A1 (enExample) |
| AU (1) | AU2022284366A1 (enExample) |
| BR (1) | BR112023024905A2 (enExample) |
| CA (1) | CA3215410A1 (enExample) |
| CL (1) | CL2023003561A1 (enExample) |
| CO (1) | CO2024000013A2 (enExample) |
| CR (1) | CR20230614A (enExample) |
| DO (1) | DOP2023000261A (enExample) |
| EC (1) | ECSP24000004A (enExample) |
| IL (1) | IL308094A (enExample) |
| JO (1) | JOP20230308A1 (enExample) |
| MX (1) | MX2023014327A (enExample) |
| PE (1) | PE20240657A1 (enExample) |
| PY (1) | PY2243958A (enExample) |
| TW (1) | TW202306570A (enExample) |
| UY (1) | UY39796A (enExample) |
| WO (1) | WO2022254362A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4667056A1 (en) | 2021-12-22 | 2025-12-24 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| LT4245756T (lt) | 2022-03-17 | 2024-11-25 | Gilead Sciences, Inc. | Ikaros cinko pirštų šeimos skaidymo medžiagos ir jų panaudojimas |
| AR130961A1 (es) | 2022-11-04 | 2025-02-05 | Bristol Myers Squibb Co | Compuestos y su uso para el tratamiento de hemoglobinopatías |
| US20250333407A1 (en) * | 2024-04-29 | 2025-10-30 | Bristol-Myers Squibb Company | Compounds and Their Use for Treatment of Hemoglobinopathies |
| CN118598797A (zh) * | 2024-05-17 | 2024-09-06 | 诚达药业股份有限公司 | 一种手性3-羟基-4-氟哌啶衍生物的合成方法及拆分方法 |
| CN121605108A (zh) * | 2024-06-25 | 2026-03-03 | 标新生物医药科技(上海)有限公司 | 含有硫/氧取代戊二酰亚胺基异吲哚啉酮骨架的双功能蛋白降解剂及它们的应用 |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| PL2536706T3 (pl) | 2010-02-11 | 2017-10-31 | Celgene Corp | Pochodne arylometoksyizoindoliny i zawierające je kompozycje oraz sposoby ich zastosowania |
| US20120302605A1 (en) | 2010-11-18 | 2012-11-29 | Deuteria Pharmaceuticals, Llc | 3-deutero-pomalidomide |
| WO2012079022A1 (en) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| US9133161B2 (en) | 2012-07-27 | 2015-09-15 | Celgene Corporation | Processes for preparing isoindoline-1,3-dione compounds |
| US20170038387A1 (en) | 2015-08-04 | 2017-02-09 | Celgene Corporation | Methods for treating chronic lymphocytic leukemia and the use of biomarkers as a predictor of clinical sensitivity to immunomodulatory therapies |
| CA3018434A1 (en) | 2016-04-22 | 2017-10-26 | Dana-Farber Cancer Institute, Inc. | Degradation of cyclin-dependent kinase 4/6 (cdk4/6) by conjugation of cdk4/6 inhibitors with e3 ligase ligand and methods of use |
| IL318681A (en) | 2016-10-11 | 2025-03-01 | Arvinas Operations Inc | Compounds and methods for targeted reduction of androgen receptor |
| AU2017367872B2 (en) | 2016-11-01 | 2022-03-31 | Arvinas, Inc. | Tau-protein targeting protacs and associated methods of use |
| CN118834201A (zh) | 2016-12-01 | 2024-10-25 | 阿尔维纳斯运营股份有限公司 | 作为雌激素受体降解剂的四氢萘和四氢异喹啉衍生物 |
| KR20190101406A (ko) | 2016-12-23 | 2019-08-30 | 아비나스 오퍼레이션스, 인코포레이티드 | Egfr 단백질분해 표적화 키메라 분자 및 관련 사용 방법 |
| WO2018118598A1 (en) | 2016-12-23 | 2018-06-28 | Arvinas, Inc. | Compounds and methods for the targeted degradation of fetal liver kinase polypeptides |
| KR102839545B1 (ko) | 2016-12-23 | 2025-07-29 | 아비나스 오퍼레이션스, 인코포레이티드 | 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법 |
| US11191741B2 (en) | 2016-12-24 | 2021-12-07 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide |
| CA3049912A1 (en) | 2017-01-26 | 2018-08-02 | Arvinas Operations, Inc. | Modulators of estrogen receptor proteolysis and associated methods of use |
| US11999802B2 (en) | 2017-10-18 | 2024-06-04 | Novartis Ag | Compositions and methods for selective protein degradation |
| WO2019079701A1 (en) | 2017-10-20 | 2019-04-25 | Dana-Farber Cancer Institute, Inc. | HETEROBIFUNCTIONAL COMPOUNDS HAVING IMPROVED SPECIFICITY FOR BRD4 BROMODOMAINE |
| US11065231B2 (en) | 2017-11-17 | 2021-07-20 | Arvinas Operations, Inc. | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides |
| IL315310A (en) | 2017-12-26 | 2024-10-01 | Kymera Therapeutics Inc | Irak degraders and uses thereof |
| US11028088B2 (en) | 2018-03-10 | 2021-06-08 | Yale University | Modulators of BTK proteolysis and methods of use |
| BR112020020307A2 (pt) | 2018-04-04 | 2021-01-12 | Arvinas Operations, Inc. | Moduladores de proteólise e métodos de uso associados |
| KR20250020690A (ko) | 2018-06-29 | 2025-02-11 | 다나-파버 캔서 인스티튜트 인크. | 세레블론(crbn)에 대한 리간드 |
| US12060366B2 (en) | 2018-06-29 | 2024-08-13 | Dana-Farber Cancer Institute, Inc. | Bispecific degraders |
| US12234220B2 (en) | 2018-06-29 | 2025-02-25 | Dana-Farber Cancer Institute, Inc. | Immunomodulatory compounds |
| EP3813834B1 (en) | 2018-06-29 | 2025-03-26 | Dana-Farber Cancer Institute, Inc. | New crbn modulators |
| BR122022012697B1 (pt) * | 2018-07-10 | 2023-04-04 | Novartis Ag | Usos de derivados de 3-(5-hidróxi-1-oxoisoindolin-2-il)piperidina-2,6- diona, e kit |
| US12227488B2 (en) * | 2018-12-03 | 2025-02-18 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of Helios and methods of use |
| JP2022548095A (ja) | 2019-09-16 | 2022-11-16 | ノバルティス アーゲー | 接着分解剤及びその使用方法 |
| CN119019369A (zh) * | 2019-10-17 | 2024-11-26 | 阿尔维纳斯运营股份有限公司 | 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子 |
| CA3164832A1 (en) * | 2019-12-18 | 2021-06-24 | Novartis Ag | 3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
-
2022
- 2022-06-01 UY UY0001039796A patent/UY39796A/es unknown
- 2022-06-01 KR KR1020237045016A patent/KR20240013812A/ko active Pending
- 2022-06-01 US US17/829,933 patent/US12103919B2/en active Active
- 2022-06-01 CN CN202280022964.9A patent/CN117062811A/zh active Pending
- 2022-06-01 PY PY202202243958A patent/PY2243958A/es unknown
- 2022-06-01 EP EP22731823.5A patent/EP4347580A1/en active Pending
- 2022-06-01 AR ARP220101454A patent/AR126052A1/es not_active Application Discontinuation
- 2022-06-01 WO PCT/IB2022/055131 patent/WO2022254362A1/en not_active Ceased
- 2022-06-01 AU AU2022284366A patent/AU2022284366A1/en not_active Abandoned
- 2022-06-01 MX MX2023014327A patent/MX2023014327A/es unknown
- 2022-06-01 CA CA3215410A patent/CA3215410A1/en active Pending
- 2022-06-01 PE PE2023003180A patent/PE20240657A1/es unknown
- 2022-06-01 JP JP2023574412A patent/JP2024520654A/ja active Pending
- 2022-06-01 TW TW111120484A patent/TW202306570A/zh unknown
- 2022-06-01 BR BR112023024905A patent/BR112023024905A2/pt not_active Application Discontinuation
- 2022-06-01 IL IL308094A patent/IL308094A/en unknown
- 2022-06-01 CR CR20230614A patent/CR20230614A/es unknown
-
2023
- 2023-11-29 JO JOJO/P/2023/0308A patent/JOP20230308A1/ar unknown
- 2023-11-29 DO DO2023000261A patent/DOP2023000261A/es unknown
- 2023-11-29 CL CL2023003561A patent/CL2023003561A1/es unknown
-
2024
- 2024-01-02 CO CONC2024/0000013A patent/CO2024000013A2/es unknown
- 2024-01-02 EC ECSENADI20244A patent/ECSP24000004A/es unknown
- 2024-09-03 US US18/823,254 patent/US20250026736A1/en active Pending
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