CO2024000013A2 - Derivados de 3–(1–oxoisoindolin–2–il)piperidina–2,6–diona y sus usos médicos - Google Patents
Derivados de 3–(1–oxoisoindolin–2–il)piperidina–2,6–diona y sus usos médicosInfo
- Publication number
- CO2024000013A2 CO2024000013A2 CONC2024/0000013A CO2024000013A CO2024000013A2 CO 2024000013 A2 CO2024000013 A2 CO 2024000013A2 CO 2024000013 A CO2024000013 A CO 2024000013A CO 2024000013 A2 CO2024000013 A2 CO 2024000013A2
- Authority
- CO
- Colombia
- Prior art keywords
- oxoisoindolin
- piperidine
- medical uses
- dione derivatives
- hemoglobinopathies
- Prior art date
Links
- WENKGSGGXGQHSH-UHFFFAOYSA-N 3-(3-oxo-1h-isoindol-2-yl)piperidine-2,6-dione Chemical class C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O WENKGSGGXGQHSH-UHFFFAOYSA-N 0.000 title 1
- 102100020716 Protein Wiz Human genes 0.000 abstract 2
- 101710186935 Protein Wiz Proteins 0.000 abstract 2
- 208000034737 hemoglobinopathy Diseases 0.000 abstract 2
- 208000018337 inherited hemoglobinopathy Diseases 0.000 abstract 2
- 208000019838 Blood disease Diseases 0.000 abstract 1
- 108010044495 Fetal Hemoglobin Proteins 0.000 abstract 1
- 208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 abstract 1
- 206010043391 Thalassaemia beta Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente solicitud se refiere a compuestos de fórmula (I), composiciones farmacéuticas que los comprenden, y su uso para reducir los niveles de expresión de los motivos de dedos de zinc ampliamente interespaciados (WIZ), o para inducir la expresión de la hemoglobina fetal (HbF), y en el tratamiento de trastornos sanguíneos hereditarios (por ejemplo, hemoglobinopatías, por ejemplo, beta–hemoglobinopatías), tales como la enfermedad de células falciformes y beta–talasemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163196422P | 2021-06-03 | 2021-06-03 | |
| PCT/IB2022/055131 WO2022254362A1 (en) | 2021-06-03 | 2022-06-01 | 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and medical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO2024000013A2 true CO2024000013A2 (es) | 2024-01-25 |
Family
ID=82115547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CONC2024/0000013A CO2024000013A2 (es) | 2021-06-03 | 2024-01-02 | Derivados de 3–(1–oxoisoindolin–2–il)piperidina–2,6–diona y sus usos médicos |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US20230019617A1 (es) |
| EP (1) | EP4347580A1 (es) |
| JP (1) | JP2024520654A (es) |
| KR (1) | KR20240013812A (es) |
| CN (1) | CN117062811A (es) |
| AR (1) | AR126052A1 (es) |
| AU (1) | AU2022284366A1 (es) |
| BR (1) | BR112023024905A2 (es) |
| CA (1) | CA3215410A1 (es) |
| CO (1) | CO2024000013A2 (es) |
| CR (1) | CR20230614A (es) |
| DO (1) | DOP2023000261A (es) |
| EC (1) | ECSP24000004A (es) |
| IL (1) | IL308094A (es) |
| MX (1) | MX2023014327A (es) |
| PE (1) | PE20240657A1 (es) |
| TW (1) | TW202306570A (es) |
| WO (1) | WO2022254362A1 (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3237577A1 (en) * | 2021-12-22 | 2023-06-29 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
| TW202346277A (zh) | 2022-03-17 | 2023-12-01 | 美商基利科學股份有限公司 | Ｉｋａｒｏｓ鋅指家族降解劑及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| JP2013543009A (ja) | 2010-11-18 | 2013-11-28 | デューテリア ファーマシューティカルズ， インコーポレイテッド | ３−ジュウテロ−ポマリドマイド |
| WO2012079022A1 (en) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| LT3689868T (lt) * | 2016-12-01 | 2023-12-27 | Arvinas Operations, Inc. | Tetrahidronaftaleno ir tetrahidroizochinolino dariniai kaip estrogenų receptorių destruktoriai |
| WO2020012334A1 (en) * | 2018-07-10 | 2020-01-16 | Novartis Ag | 3-(5-hydroxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and their use in the treatment of ikaros family zinc finger 2 (ikzf2)-dependent diseases |
| US20220177443A1 (en) * | 2018-12-03 | 2022-06-09 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of helios and methods of use |
| JP2022552006A (ja) * | 2019-10-17 | 2022-12-14 | アルヴィナス・オペレーションズ・インコーポレイテッド | Ｂｃｌ６標的化部分に連結されたｅ３ユビキチンリガーゼ結合部分を含有する二官能性分子 |
| AU2020410514A1 (en) * | 2019-12-18 | 2022-06-30 | Novartis Ag | 3-(5-methoxy-1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and uses thereof |
-
2022
- 2022-06-01 JP JP2023574412A patent/JP2024520654A/ja active Pending
- 2022-06-01 US US17/829,933 patent/US20230019617A1/en active Pending
- 2022-06-01 IL IL308094A patent/IL308094A/en unknown
- 2022-06-01 BR BR112023024905A patent/BR112023024905A2/pt unknown
- 2022-06-01 AR ARP220101454A patent/AR126052A1/es unknown
- 2022-06-01 KR KR1020237045016A patent/KR20240013812A/ko active Search and Examination
- 2022-06-01 CA CA3215410A patent/CA3215410A1/en active Pending
- 2022-06-01 WO PCT/IB2022/055131 patent/WO2022254362A1/en active Application Filing
- 2022-06-01 EP EP22731823.5A patent/EP4347580A1/en active Pending
- 2022-06-01 PE PE2023003180A patent/PE20240657A1/es unknown
- 2022-06-01 CR CR20230614A patent/CR20230614A/es unknown
- 2022-06-01 TW TW111120484A patent/TW202306570A/zh unknown
- 2022-06-01 CN CN202280022964.9A patent/CN117062811A/zh active Pending
- 2022-06-01 MX MX2023014327A patent/MX2023014327A/es unknown
- 2022-06-01 AU AU2022284366A patent/AU2022284366A1/en active Pending
-
2023
- 2023-11-29 DO DO2023000261A patent/DOP2023000261A/es unknown
-
2024
- 2024-01-02 CO CONC2024/0000013A patent/CO2024000013A2/es unknown
- 2024-01-02 EC ECSENADI20244A patent/ECSP24000004A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2023014327A (es) | 2023-12-13 |
| BR112023024905A2 (pt) | 2024-02-20 |
| WO2022254362A1 (en) | 2022-12-08 |
| AU2022284366A1 (en) | 2023-10-26 |
| KR20240013812A (ko) | 2024-01-30 |
| ECSP24000004A (es) | 2024-02-29 |
| CR20230614A (es) | 2024-02-01 |
| DOP2023000261A (es) | 2023-12-29 |
| PE20240657A1 (es) | 2024-04-04 |
| CN117062811A (zh) | 2023-11-14 |
| JP2024520654A (ja) | 2024-05-24 |
| AR126052A1 (es) | 2023-09-06 |
| TW202306570A (zh) | 2023-02-16 |
| CA3215410A1 (en) | 2022-12-08 |
| IL308094A (en) | 2023-12-01 |
| US20230019617A1 (en) | 2023-01-19 |
| EP4347580A1 (en) | 2024-04-10 |
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