BR112023024905A2 - Derivados de 3-(5-oxoisoindolin-2-il)piperidina-2,6-diona e seus usos - Google Patents
Derivados de 3-(5-oxoisoindolin-2-il)piperidina-2,6-diona e seus usosInfo
- Publication number
- BR112023024905A2 BR112023024905A2 BR112023024905A BR112023024905A BR112023024905A2 BR 112023024905 A2 BR112023024905 A2 BR 112023024905A2 BR 112023024905 A BR112023024905 A BR 112023024905A BR 112023024905 A BR112023024905 A BR 112023024905A BR 112023024905 A2 BR112023024905 A2 BR 112023024905A2
- Authority
- BR
- Brazil
- Prior art keywords
- oxoisoindolin
- piperidine
- dione derivatives
- hemoglobinopathies
- beta
- Prior art date
Links
- 150000005459 piperidine-2,6-diones Chemical class 0.000 title 1
- 102100020716 Protein Wiz Human genes 0.000 abstract 2
- 101710186935 Protein Wiz Proteins 0.000 abstract 2
- 208000034737 hemoglobinopathy Diseases 0.000 abstract 2
- 208000018337 inherited hemoglobinopathy Diseases 0.000 abstract 2
- -1 3-(5-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives Chemical class 0.000 abstract 1
- 208000019838 Blood disease Diseases 0.000 abstract 1
- 108010044495 Fetal Hemoglobin Proteins 0.000 abstract 1
- 208000018020 Sickle cell-beta-thalassemia disease syndrome Diseases 0.000 abstract 1
- 206010043391 Thalassaemia beta Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000014951 hematologic disease Diseases 0.000 abstract 1
- 208000018706 hematopoietic system disease Diseases 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
derivados de 3-(5-oxoisoindolin-2- il)piperidina-2,6-diona e seus usos. a presente invenção refere-se a compostos da fórmula (i), composições farmacêuticas compreendendo os mesmos e seu uso na redução dos níveis de expressão de motivos de dedo de zinco amplamente interespaçados (wiz) ou na indução da expressão da hemoglobina fetal (hbf) e no tratamento de disfunções sanguíneas hereditárias (p. ex., hemoglobinopatias, p. ex., beta-hemoglobinopatias), tais como doença das células falciformes e beta-talassemia.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163196422P | 2021-06-03 | 2021-06-03 | |
| PCT/IB2022/055131 WO2022254362A1 (en) | 2021-06-03 | 2022-06-01 | 3-(1-oxoisoindolin-2-yl)piperidine-2,6-dione derivatives and medical uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112023024905A2 true BR112023024905A2 (pt) | 2024-02-20 |
Family
ID=82115547
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112023024905A BR112023024905A2 (pt) | 2021-06-03 | 2022-06-01 | Derivados de 3-(5-oxoisoindolin-2-il)piperidina-2,6-diona e seus usos |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230019617A1 (pt) |
| EP (1) | EP4347580A1 (pt) |
| KR (1) | KR20240013812A (pt) |
| CN (1) | CN117062811A (pt) |
| AR (1) | AR126052A1 (pt) |
| AU (1) | AU2022284366A1 (pt) |
| BR (1) | BR112023024905A2 (pt) |
| CA (1) | CA3215410A1 (pt) |
| CO (1) | CO2024000013A2 (pt) |
| CR (1) | CR20230614A (pt) |
| DO (1) | DOP2023000261A (pt) |
| EC (1) | ECSP24000004A (pt) |
| IL (1) | IL308094A (pt) |
| PE (1) | PE20240657A1 (pt) |
| TW (1) | TW202306570A (pt) |
| WO (1) | WO2022254362A1 (pt) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4245756A1 (en) | 2022-03-17 | 2023-09-20 | Gilead Sciences, Inc. | Ikaros zinc finger family degraders and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007524596A (ja) | 2003-02-28 | 2007-08-30 | トランスフォーム・ファーマシューティカルズ・インコーポレイテッド | 共結晶医薬組成物 |
| JP2013543009A (ja) | 2010-11-18 | 2013-11-28 | デューテリア ファーマシューティカルズ， インコーポレイテッド | ３−ジュウテロ−ポマリドマイド |
| WO2012079022A1 (en) | 2010-12-10 | 2012-06-14 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| IL297717A (en) * | 2016-12-01 | 2022-12-01 | Arvinas Operations Inc | History of tetrahydronaphthalene and tetrahydroisoquinoline as estrogen receptor antagonists |
| PL3820573T3 (pl) * | 2018-07-10 | 2024-02-19 | Novartis Ag | Pochodne 3-(5-hydroksy-1-oksoizoindolin-2-ylo)piperydyno-2,6-dionu i ich zastosowanie w leczeniu chorób zależnych od palca cynkowego z rodziny ikaros 2 (ikzf2) |
| CA3119526A1 (en) * | 2018-12-03 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Small molecule degraders of helios and methods of use |
| US20220323457A1 (en) * | 2019-10-17 | 2022-10-13 | Arvinas Operations, Inc. | Modulators of bcl6 proteolysis and associated methods of use |
| UY38986A (es) * | 2019-12-18 | 2021-07-30 | Novartis Ag | Compuestos derivados de 3-(5-metoxi-1-oxoisoindolin-2-il) piperidin-2,6-diona, métodos de usos de los mismos y combinaciones farmacéuticas |
-
2022
- 2022-06-01 BR BR112023024905A patent/BR112023024905A2/pt unknown
- 2022-06-01 TW TW111120484A patent/TW202306570A/zh unknown
- 2022-06-01 US US17/829,933 patent/US20230019617A1/en active Pending
- 2022-06-01 CA CA3215410A patent/CA3215410A1/en active Pending
- 2022-06-01 WO PCT/IB2022/055131 patent/WO2022254362A1/en active Application Filing
- 2022-06-01 PE PE2023003180A patent/PE20240657A1/es unknown
- 2022-06-01 CN CN202280022964.9A patent/CN117062811A/zh active Pending
- 2022-06-01 CR CR20230614A patent/CR20230614A/es unknown
- 2022-06-01 AR ARP220101454A patent/AR126052A1/es unknown
- 2022-06-01 KR KR1020237045016A patent/KR20240013812A/ko active Search and Examination
- 2022-06-01 IL IL308094A patent/IL308094A/en unknown
- 2022-06-01 AU AU2022284366A patent/AU2022284366A1/en active Pending
- 2022-06-01 EP EP22731823.5A patent/EP4347580A1/en active Pending
-
2023
- 2023-11-29 DO DO2023000261A patent/DOP2023000261A/es unknown
-
2024
- 2024-01-02 CO CONC2024/0000013A patent/CO2024000013A2/es unknown
- 2024-01-02 EC ECSENADI20244A patent/ECSP24000004A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR126052A1 (es) | 2023-09-06 |
| CR20230614A (es) | 2024-02-01 |
| EP4347580A1 (en) | 2024-04-10 |
| DOP2023000261A (es) | 2023-12-29 |
| AU2022284366A1 (en) | 2023-10-26 |
| TW202306570A (zh) | 2023-02-16 |
| PE20240657A1 (es) | 2024-04-04 |
| CO2024000013A2 (es) | 2024-01-25 |
| CN117062811A (zh) | 2023-11-14 |
| US20230019617A1 (en) | 2023-01-19 |
| CA3215410A1 (en) | 2022-12-08 |
| KR20240013812A (ko) | 2024-01-30 |
| WO2022254362A1 (en) | 2022-12-08 |
| IL308094A (en) | 2023-12-01 |
| ECSP24000004A (es) | 2024-02-29 |
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