CY1115734T1 - Συνθεσεις benzenesulfonamide, μεθοδος συνθεσης τους, και χρηση αυτων στην ιατρικη - Google Patents

Συνθεσεις benzenesulfonamide, μεθοδος συνθεσης τους, και χρηση αυτων στην ιατρικη

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Publication number
CY1115734T1
CY1115734T1 CY20141100801T CY141100801T CY1115734T1 CY 1115734 T1 CY1115734 T1 CY 1115734T1 CY 20141100801 T CY20141100801 T CY 20141100801T CY 141100801 T CY141100801 T CY 141100801T CY 1115734 T1 CY1115734 T1 CY 1115734T1
Authority
CY
Cyprus
Prior art keywords
compositions
benzenesulfonamide
medical
composition
benzenesulfonamides
Prior art date
Application number
CY20141100801T
Other languages
English (en)
Inventor
Laurence Clary
Sandrine Chambon
Laurent Chantalat
Carine Rosignoli
Olivier Roye
Jean-Claude Pascal
Marlène Schuppli
Original Assignee
Galderma Research & Development
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Galderma Research & Development filed Critical Galderma Research & Development
Publication of CY1115734T1 publication Critical patent/CY1115734T1/el

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Abstract

Η παρούσα εφεύρεση αναφέρεται σε νέες συνθέσεις benzenesulfonamides με δομή που αντιστοιχεί στον ακόλουθο γενικό τύπο (I): καθώς και στην διαδικασία της σύνθεσης τους και στην χρήση τους σε φαρμακευτικές συνθέσεις που προορίζονται για χρήση στην ανθρώπινη ιατρική ή κτηνιατρική ή στην χρήση τους σε συνθέσεις καλλυντικών.
CY20141100801T 2009-06-30 2014-10-03 Συνθεσεις benzenesulfonamide, μεθοδος συνθεσης τους, και χρηση αυτων στην ιατρικη CY1115734T1 (el)

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FR0954460A FR2947268B1 (fr) 2009-06-30 2009-06-30 Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
EP10745348.2A EP2448920B1 (fr) 2009-06-30 2010-06-28 Composés de benzène-sulfonamides, leur procédé de synthèse et leur utilisation en médecine

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Publication number Priority date Publication date Assignee Title
FR2947268B1 (fr) 2009-06-30 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
FR2950057B1 (fr) * 2009-09-17 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-carboxylamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique
US9586832B2 (en) * 2013-03-15 2017-03-07 Dru L. DeLaet Method for destruction of halons
US20140275108A1 (en) * 2013-03-15 2014-09-18 Galderma Research & Development Novel benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine as well as in cosmetics
CN103224476A (zh) * 2013-05-25 2013-07-31 上高县瑞雅精细化工有限公司 二乙醇胺法制备1-[2-(2-羟基乙氧基)乙基]哌嗪新工艺
FR3030521B1 (fr) * 2014-12-23 2019-07-26 Galderma Research & Development Nouveaux composes heterocycliques et leur utilisation en medecine ainsi qu'en cosmetique
EP3199534B1 (en) 2016-02-01 2018-09-05 Galderma Research & Development Benzenesulfonamide compounds, method for synthesizing same, and use thereof in medicine and cosmetics

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506242A (en) 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
DK0861236T4 (da) 1995-11-13 2006-12-18 Sanofi Aventis Deutschland Cykliske og heterocykliske N-substituerede alphaiminohydroxam- og carboxylsyrer
TW453995B (en) 1995-12-15 2001-09-11 Novartis Ag Certain alpha-substituted arylsulfonamido acetohydroxamic acids
TW448172B (en) * 1996-03-08 2001-08-01 Pharmacia & Upjohn Co Llc Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation
BR9712525A (pt) 1996-10-16 1999-10-19 American Cyanamid Co O preparo e uso de ácidos orto-sulfonamido aril hidrox‰micos como inibidores da metaloproteinase matricial e da tace
ATE229949T1 (de) 1996-10-16 2003-01-15 American Cyanamid Co Herstellung und verwendung von ortho-sulfonamido- heteroarylhydroxamsäuren als matrix- metalloproteinase und tace inhibitoren
KR20000049198A (ko) 1996-10-16 2000-07-25 윌리암 에이취 캘넌, 에곤 이 버그 매트릭스 메탈로프로티나아제 및 tace 억제제로서의 베타-설폰아미도 하이드록스암산
AU743901B2 (en) 1996-10-16 2002-02-07 Wyeth Holdings Corporation Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors
JP3563411B2 (ja) 1997-01-23 2004-09-08 エフ・ホフマン−ラ ロシュ アーゲー スルファミド−メタロプロテアーゼ阻害剤
KR20010041089A (ko) 1998-02-19 2001-05-15 윌리암 에이취 캘넌, 에곤 이 버그 매트릭스 메탈로프로테이나제 억제제로서의n-하이드록시-2-(알킬, 아릴, 또는 헤테로아릴 설파닐,설피닐 또는 설포닐)-3-치환된 알킬, 아릴 또는헤테로아릴아미드
JP3092798B2 (ja) * 1998-06-30 2000-09-25 日本電気株式会社 適応送受信装置
CZ20012294A3 (cs) * 1998-12-22 2001-12-12 F. Hoffmann-La Roche Ag Sulfonamidové hydroxamáty
AR035313A1 (es) 1999-01-27 2004-05-12 Wyeth Corp Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos.
AR035478A1 (es) 1999-01-27 2004-06-02 Wyeth Corp Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene
US6326516B1 (en) * 1999-01-27 2001-12-04 American Cyanamid Company Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors
ATE420068T1 (de) * 2001-09-07 2009-01-15 Kaken Pharma Co Ltd Reverse hydroxamsäurederivate
EP1440057A1 (en) * 2001-11-01 2004-07-28 Wyeth Holdings Corporation Allenic aryl sulfonamide hydroxamic acids as matrix metalloproteinase and tace inhibitors
TW200616612A (en) * 2004-10-08 2006-06-01 Wyeth Corp Method for the teatment of polycystic kidney disease field of invention
US20080085893A1 (en) 2006-10-06 2008-04-10 Shyh-Ming Yang Matrix metalloprotease inhibitors
FR2947268B1 (fr) * 2009-06-30 2011-08-26 Galderma Res & Dev Nouveaux composes benzene-sulfonamides, leur procede de synthese et leur utilisation en medecine ainsi qu'en cosmetique

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CA2764193A1 (en) 2011-01-06
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US20150158834A1 (en) 2015-06-11
RU2528826C2 (ru) 2014-09-20
CA2764193C (en) 2016-01-19
MX2011013130A (es) 2012-02-13
RU2014127843A (ru) 2016-01-27
EP2448920B1 (fr) 2014-08-13
JP2014224152A (ja) 2014-12-04
SMT201400168B (it) 2015-01-15
US8633196B2 (en) 2014-01-21
US20130172363A1 (en) 2013-07-04
US9365529B2 (en) 2016-06-14
KR20120044350A (ko) 2012-05-07
IN2011KN05169A (el) 2015-07-17
KR20140095108A (ko) 2014-07-31
PT2448920E (pt) 2014-09-17
US20120323006A1 (en) 2012-12-20
CN102471260A (zh) 2012-05-23
DK2448920T3 (da) 2014-09-29
FR2947268A1 (fr) 2010-12-31
US20140107129A1 (en) 2014-04-17
AU2010267872C1 (en) 2014-04-10
HK1206006A1 (en) 2015-12-31
CN102471260B (zh) 2014-10-22
AU2010267872B2 (en) 2013-10-10
ES2501640T3 (es) 2014-10-02
SI2448920T1 (sl) 2014-12-31
US20160280650A1 (en) 2016-09-29
FR2947268B1 (fr) 2011-08-26
JP2012531460A (ja) 2012-12-10
JP5607154B2 (ja) 2014-10-15
WO2011001089A1 (fr) 2011-01-06
US8980897B2 (en) 2015-03-17
HRP20140881T1 (hr) 2014-12-19
KR101513783B1 (ko) 2015-04-20
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