JPWO2022247943A5 - - Google Patents
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- JPWO2022247943A5 JPWO2022247943A5 JP2023573373A JP2023573373A JPWO2022247943A5 JP WO2022247943 A5 JPWO2022247943 A5 JP WO2022247943A5 JP 2023573373 A JP2023573373 A JP 2023573373A JP 2023573373 A JP2023573373 A JP 2023573373A JP WO2022247943 A5 JPWO2022247943 A5 JP WO2022247943A5
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- JP
- Japan
- Prior art keywords
- intron
- fragment
- group
- exon
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110594352.4 | 2021-05-28 | ||
| CN202110594352.4A CN115404240A (zh) | 2021-05-28 | 2021-05-28 | 制备环形rna的构建体、方法及其用途 |
| PCT/CN2022/095749 WO2022247943A1 (en) | 2021-05-28 | 2022-05-27 | Constructs and methods for preparing circular rnas and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024520534A JP2024520534A (ja) | 2024-05-24 |
| JP2024520534A5 JP2024520534A5 (https=) | 2025-06-04 |
| JPWO2022247943A5 true JPWO2022247943A5 (https=) | 2025-06-04 |
Family
ID=82594734
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023573373A Pending JP2024520534A (ja) | 2021-05-28 | 2022-05-27 | 環状ｒｎａを調製するための構築物及び方法並びにその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240279676A1 (https=) |
| EP (1) | EP4347841A1 (https=) |
| JP (1) | JP2024520534A (https=) |
| CN (2) | CN115404240A (https=) |
| WO (1) | WO2022247943A1 (https=) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2994006T3 (en) | 2021-09-17 | 2025-01-16 | Flagship Pioneering Innovations Vi Llc | Compositions and methods for producing circular polyribonucleotides |
| JP2024546855A (ja) | 2021-12-17 | 2024-12-26 | フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー | 変性条件下での環状ｒｎａの濃縮方法 |
| KR20240117149A (ko) | 2021-12-22 | 2024-07-31 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법 |
| MX2024007870A (es) | 2021-12-23 | 2024-08-15 | Flagship Pioneering Innovations Vi Llc | Polirribonucleotidos circulares que codifican polipeptidos antifusogenicos. |
| CN118871134A (zh) * | 2022-03-21 | 2024-10-29 | 生物探险有限公司 | 用于增强蛋白质表达的内部核糖体进入位点（IRES）、质粒载体和环状mRNA |
| WO2024151583A2 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations Vii, Llc | Vaccines and related methods |
| WO2024167885A1 (en) | 2023-02-06 | 2024-08-15 | Flagship Pioneering Innovations Vii, Llc | Immunomodulatory compositions and related methods |
| EP4680276A1 (en) | 2023-03-15 | 2026-01-21 | Flagship Pioneering Innovations VI, LLC | Immunogenic compositions and uses thereof |
| WO2024192420A1 (en) | 2023-03-15 | 2024-09-19 | Flagship Pioneering Innovations Vi, Llc | Compositions comprising polyribonucleotides and uses thereof |
| CN117070564B (zh) * | 2023-03-30 | 2024-05-10 | 安可来(重庆)生物医药科技有限公司 | 一种用于合成环形rna的质粒及其构建方法与一种环形rna及其体外合成方法 |
| EP4698150A1 (en) | 2023-04-19 | 2026-02-25 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024220712A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Vaccine compositions |
| WO2024220752A2 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Rna therapeutic compositions |
| WO2024233308A2 (en) * | 2023-05-05 | 2024-11-14 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| WO2024236366A2 (en) * | 2023-05-12 | 2024-11-21 | Sekkei Bio Private Limited | Design and method of generating scarless circular rna |
| TW202500164A (zh) * | 2023-05-23 | 2025-01-01 | 北京大學 | 形成環形ｒｎａ的方法 |
| WO2025006684A1 (en) | 2023-06-28 | 2025-01-02 | Flagship Pioneering Innovations Vi, Llc | Circular polyribonucleotides encoding antifusogenic polypeptides |
| CN121752588A (zh) * | 2023-08-29 | 2026-03-27 | 上海环码生物医药有限公司 | 编码vegf多肽的环状rna、制剂和使用方法 |
| WO2025054282A1 (en) * | 2023-09-06 | 2025-03-13 | Massachusetts Institute Of Technology | Engineered synthetic ires with improved and robust translation in circular rna |
| WO2025077734A1 (en) * | 2023-10-09 | 2025-04-17 | Shanghai Circode Biomed Co., Ltd. | Constructs and methods for preparing circular rnas and uses thereof |
| WO2025106915A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof |
| WO2025106930A1 (en) | 2023-11-17 | 2025-05-22 | Sail Biomedicines, Inc. | Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof |
| WO2025111280A1 (en) * | 2023-11-20 | 2025-05-30 | Strand Therapeutics Inc. | Circular rna synthesis |
| WO2025122609A1 (en) * | 2023-12-04 | 2025-06-12 | Strand Therapeutics Inc. | Circular rna synthesis |
| CN118240812A (zh) * | 2024-01-10 | 2024-06-25 | 上海环码生物医药有限公司 | 用于纯化环状核酸的阳选方法和系统 |
| TW202545974A (zh) | 2024-01-26 | 2025-12-01 | 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 | 免疫受體抑制蛋白及相關方法 |
| WO2025179198A1 (en) | 2024-02-23 | 2025-08-28 | Sail Biomedicines, Inc. | Circular polyribonucleotides and unmodified linear rnas with reduced immunogenicity |
| WO2025180449A1 (zh) * | 2024-02-28 | 2025-09-04 | 山西高等创新研究院 | 一种基于i型内含子核酶体外制备环状rna的系统及其应用 |
| WO2025190113A1 (zh) * | 2024-03-14 | 2025-09-18 | 广州国家实验室 | 一种用于制备环状rna的载体及其应用 |
| WO2025240680A1 (en) | 2024-05-16 | 2025-11-20 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor inhibitory proteins and related methods |
| WO2025245111A1 (en) | 2024-05-22 | 2025-11-27 | Flagship Pioneering Innovations Vii, Llc | Immunoreceptor targeting proteins and related methods |
| WO2025247180A1 (zh) * | 2024-05-27 | 2025-12-04 | 南京金斯瑞生物科技有限公司 | 用于制备含较少非目的序列的环状rna的载体和方法 |
| WO2025259931A1 (en) * | 2024-06-14 | 2025-12-18 | Orbital Therapeutics, Inc. | Compositions and methods for rna circularization |
| CN118703488A (zh) * | 2024-06-20 | 2024-09-27 | 毕昇(北京)生物科技有限公司 | 一种环状rna的纯化方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3832253A (en) | 1973-03-21 | 1974-08-27 | Baxter Laboratories Inc | Method of making an inflatable balloon catheter |
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4667014A (en) | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| CA1200416A (en) | 1983-05-13 | 1986-02-11 | Societe Des Produits Nestle S.A. | Food process |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| IN165717B (https=) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH04167172A (ja) | 1990-10-31 | 1992-06-15 | Nec Corp | ベクトルプロセッサ |
| US5498531A (en) * | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| US6150141A (en) * | 1993-09-10 | 2000-11-21 | Trustees Of Boston University | Intron-mediated recombinant techniques and reagents |
| EP3472193A4 (en) * | 2016-06-20 | 2020-01-08 | The Board of Trustees of the Leland Stanford Junior University | CIRCULAR RNA AND THEIR USE IN IMMUNOMODULATION |
| CA3100276A1 (en) * | 2018-06-06 | 2019-12-12 | Massachusetts Institute Of Technology | Circular rna for translation in eukaryotic cells |
| EP4022069A4 (en) * | 2019-08-28 | 2023-12-20 | The Board of Trustees of the Leland Stanford Junior University | MODIFIED CIRCULAR RNAS AND METHOD OF USE THEREOF |
-
2021
- 2021-05-28 CN CN202110594352.4A patent/CN115404240A/zh active Pending
-
2022
- 2022-05-27 JP JP2023573373A patent/JP2024520534A/ja active Pending
- 2022-05-27 EP EP22743438.8A patent/EP4347841A1/en active Pending
- 2022-05-27 CN CN202280038559.6A patent/CN117413065A/zh active Pending
- 2022-05-27 WO PCT/CN2022/095749 patent/WO2022247943A1/en not_active Ceased
- 2022-05-27 US US18/564,274 patent/US20240279676A1/en active Pending
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