JP2025183226A5 - - Google Patents
Info
- Publication number
- JP2025183226A5 JP2025183226A5 JP2025135451A JP2025135451A JP2025183226A5 JP 2025183226 A5 JP2025183226 A5 JP 2025183226A5 JP 2025135451 A JP2025135451 A JP 2025135451A JP 2025135451 A JP2025135451 A JP 2025135451A JP 2025183226 A5 JP2025183226 A5 JP 2025183226A5
- Authority
- JP
- Japan
- Prior art keywords
- spcas9
- acid sequence
- amino acid
- seq
- domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962893638P | 2019-08-29 | 2019-08-29 | |
| US62/893,638 | 2019-08-29 | ||
| PCT/US2020/048510 WO2021041885A2 (en) | 2019-08-29 | 2020-08-28 | Compositions and methods for editing a mutation to permit transcription or expression |
| JP2022513443A JP7781742B2 (ja) | 2019-08-29 | 2020-08-28 | 転写または発現を可能にするように変異を編集するための組成物および方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513443A Division JP7781742B2 (ja) | 2019-08-29 | 2020-08-28 | 転写または発現を可能にするように変異を編集するための組成物および方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025183226A JP2025183226A (ja) | 2025-12-16 |
| JP2025183226A5 true JP2025183226A5 (https=) | 2026-02-25 |
Family
ID=74684607
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513443A Active JP7781742B2 (ja) | 2019-08-29 | 2020-08-28 | 転写または発現を可能にするように変異を編集するための組成物および方法 |
| JP2025135451A Pending JP2025183226A (ja) | 2019-08-29 | 2025-08-15 | 転写または発現を可能にするように変異を編集するための組成物および方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022513443A Active JP7781742B2 (ja) | 2019-08-29 | 2020-08-28 | 転写または発現を可能にするように変異を編集するための組成物および方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220313799A1 (https=) |
| EP (1) | EP4022050A4 (https=) |
| JP (2) | JP7781742B2 (https=) |
| KR (1) | KR20220066289A (https=) |
| CN (2) | CN119913134A (https=) |
| AU (1) | AU2020336953A1 (https=) |
| CA (1) | CA3152861A1 (https=) |
| WO (1) | WO2021041885A2 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3847254A4 (en) | 2018-09-07 | 2022-08-10 | Beam Therapeutics Inc. | COMPOSITIONS AND METHODS FOR DELIVERING A NUCLEOBASE EDITING SYSTEM |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| EP4143315A1 (en) | 2020-04-28 | 2023-03-08 | The Broad Institute Inc. | <smallcaps/>? ? ?ush2a? ? ? ? ?targeted base editing of thegene |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| US20240173353A1 (en) * | 2021-03-16 | 2024-05-30 | Shanghai Iaso Biotechnology Co., Ltd. | Universal chimeric antigen receptor t-cell and application thereof |
| KR20240007651A (ko) * | 2021-04-16 | 2024-01-16 | 빔 테라퓨틱스, 인크. | 간세포의 유전적 변형 |
| EP4441074A2 (en) | 2021-12-03 | 2024-10-09 | The Broad Institute, Inc. | Compositions and methods for efficient in vivo delivery |
| CN120303407A (zh) | 2022-05-17 | 2025-07-11 | 恩维洛普治疗有限责任公司 | 用于有效体内递送的组合物和方法 |
| KR20230166378A (ko) | 2022-05-30 | 2023-12-07 | 현대자동차주식회사 | 차량의 제동 방법 및 장치 |
| WO2024138131A1 (en) * | 2022-12-22 | 2024-06-27 | Trustees Of Tufts College | Expanding applications of zgtc alphabet in protein expression and gene editing |
| WO2025064656A1 (en) * | 2023-09-19 | 2025-03-27 | Beam Therapeutics Inc. | Compositions and methods for altering a nucleobase in a lipoprotein(a) polynucleotide |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003258437A1 (en) * | 2002-08-30 | 2004-03-19 | The Hospital For Sick Children | Diagnosis of shwachman-diamond syndrome |
| WO2009061442A1 (en) * | 2007-11-06 | 2009-05-14 | Children's Medical Center Corporation | Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells |
| CN106604994B (zh) * | 2014-06-23 | 2021-12-14 | 通用医疗公司 | 通过测序评估的DSBs的全基因组无偏鉴定(GUIDE-Seq) |
| IL310721B2 (en) * | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| WO2018119359A1 (en) * | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| AU2018251801B2 (en) * | 2017-04-12 | 2024-11-07 | Massachusetts Institute Of Technology | Novel type VI CRISPR orthologs and systems |
| KR20250107288A (ko) * | 2017-10-16 | 2025-07-11 | 더 브로드 인스티튜트, 인코퍼레이티드 | 아데노신 염기 편집제의 용도 |
| CN109306361B (zh) * | 2018-02-11 | 2022-06-28 | 华东师范大学 | 一种新的a/t到g/c碱基定点转换的基因编辑系统 |
-
2020
- 2020-08-28 JP JP2022513443A patent/JP7781742B2/ja active Active
- 2020-08-28 KR KR1020227010126A patent/KR20220066289A/ko active Pending
- 2020-08-28 CA CA3152861A patent/CA3152861A1/en active Pending
- 2020-08-28 AU AU2020336953A patent/AU2020336953A1/en active Pending
- 2020-08-28 CN CN202411970155.8A patent/CN119913134A/zh active Pending
- 2020-08-28 EP EP20856306.4A patent/EP4022050A4/en active Pending
- 2020-08-28 WO PCT/US2020/048510 patent/WO2021041885A2/en not_active Ceased
- 2020-08-28 CN CN202080076243.7A patent/CN114641567B/zh active Active
- 2020-08-28 US US17/638,757 patent/US20220313799A1/en active Pending
-
2025
- 2025-08-15 JP JP2025135451A patent/JP2025183226A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025183226A5 (https=) | ||
| JP2022545950A5 (https=) | ||
| US11963982B2 (en) | CRISPR/RNA-guided nuclease systems and methods | |
| JP2026064992A (ja) | β異常ヘモグロビン症を治療するためのＣＲＩＳＰＲ／ＣＡＳ関連方法および組成物 | |
| JP2022546608A5 (https=) | ||
| JP2024511163A5 (https=) | ||
| US20250073352A1 (en) | Genome editing compositions and methods for treatment of fragile x syndrome | |
| JP2024533313A5 (https=) | ||
| US20240360476A1 (en) | Genome Editing Compositions and Methods for Treatment of Myotonic Dystrophy | |
| JP2024511131A5 (https=) | ||
| KR20070103483A (ko) | 아데노바이러스 벡터 및 상동 재조합 현상을 줄이는 방법 | |
| CA3093289A1 (en) | Systems and methods for the treatment of hemoglobinopathies | |
| CN111304258A (zh) | Ndufs2基因条件性点突变小鼠模型及其构建方法和应用 | |
| EP4430188A1 (en) | Genome editing compositions and methods for treatment of amyotrophic lateral sclerosis | |
| CN114752629B (zh) | 一种针对细胞中单个或多个基因进行基因编辑的方法、产品和应用 | |
| JP2024546841A5 (https=) | ||
| JP7736329B2 (ja) | Ｄｕｘ４遺伝子を標的とした顔面肩甲上腕型筋ジストロフィーの治療方法 | |
| JP2021522825A5 (https=) | ||
| KR102876548B1 (ko) | Francisella novicida Cas9 모듈 기반의 역전사 효소를 사용한 유전체 치환 및 삽입 기술 | |
| JP7769691B2 (ja) | 新規の改良された塩基編集または編集用融合タンパク質およびその用途 | |
| CN114560946B (zh) | 无pam限制的腺嘌呤单碱基编辑产品、方法和应用 | |
| CN115247162B (zh) | 一种腺嘌呤碱基编辑用融合蛋白及其应用 | |
| KR20230110194A (ko) | 슈반 세포 특이적 프로모터 | |
| CN110577970B (zh) | CRISPR/Sa-SlutCas9基因编辑系统及其应用 | |
| JP2024513967A5 (https=) |