CN115404240A - 制备环形rna的构建体、方法及其用途 - Google Patents

制备环形rna的构建体、方法及其用途 Download PDF

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CN115404240A
CN115404240A CN202110594352.4A CN202110594352A CN115404240A CN 115404240 A CN115404240 A CN 115404240A CN 202110594352 A CN202110594352 A CN 202110594352A CN 115404240 A CN115404240 A CN 115404240A
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intron
sequence
rna
fragment
type
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杨赟
王泽峰
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Shanghai Huanma Biopharmaceutical Co ltd
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Shanghai Huanma Biopharmaceutical Co ltd
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Priority to CN202110594352.4A priority Critical patent/CN115404240A/zh
Priority to EP22743438.8A priority patent/EP4347841A1/en
Priority to US18/564,274 priority patent/US20240279676A1/en
Priority to JP2023573373A priority patent/JP2024520534A/ja
Priority to PCT/CN2022/095749 priority patent/WO2022247943A1/en
Priority to CN202280038559.6A priority patent/CN117413065A/zh
Publication of CN115404240A publication Critical patent/CN115404240A/zh
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CN202110594352.4A 2021-05-28 2021-05-28 制备环形rna的构建体、方法及其用途 Pending CN115404240A (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN202110594352.4A CN115404240A (zh) 2021-05-28 2021-05-28 制备环形rna的构建体、方法及其用途
EP22743438.8A EP4347841A1 (en) 2021-05-28 2022-05-27 Constructs and methods for preparing circular rnas and use thereof
US18/564,274 US20240279676A1 (en) 2021-05-28 2022-05-27 Constructs and methods for preparing circular rnas and use thereof
JP2023573373A JP2024520534A (ja) 2021-05-28 2022-05-27 環状ｒｎａを調製するための構築物及び方法並びにその使用
PCT/CN2022/095749 WO2022247943A1 (en) 2021-05-28 2022-05-27 Constructs and methods for preparing circular rnas and use thereof
CN202280038559.6A CN117413065A (zh) 2021-05-28 2022-05-27 制备环形rna的构建体、方法及其用途

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CN202110594352.4A CN115404240A (zh) 2021-05-28 2021-05-28 制备环形rna的构建体、方法及其用途

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CN202280038559.6A Pending CN117413065A (zh) 2021-05-28 2022-05-27 制备环形rna的构建体、方法及其用途

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US (1) US20240279676A1 (https=)
EP (1) EP4347841A1 (https=)
JP (1) JP2024520534A (https=)
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WO (1) WO2022247943A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025077734A1 (en) * 2023-10-09 2025-04-17 Shanghai Circode Biomed Co., Ltd. Constructs and methods for preparing circular rnas and uses thereof
WO2025190113A1 (zh) * 2024-03-14 2025-09-18 广州国家实验室 一种用于制备环状rna的载体及其应用
WO2025260408A1 (zh) * 2024-06-20 2025-12-26 毕昇(北京)生物科技有限公司 一种环状rna的纯化方法

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ES2994006T3 (en) 2021-09-17 2025-01-16 Flagship Pioneering Innovations Vi Llc Compositions and methods for producing circular polyribonucleotides
JP2024546855A (ja) 2021-12-17 2024-12-26 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 変性条件下での環状ｒｎａの濃縮方法
KR20240117149A (ko) 2021-12-22 2024-07-31 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 폴리리보뉴클레오티드를 정제하기 위한 조성물 및 방법
MX2024007870A (es) 2021-12-23 2024-08-15 Flagship Pioneering Innovations Vi Llc Polirribonucleotidos circulares que codifican polipeptidos antifusogenicos.
CN118871134A (zh) * 2022-03-21 2024-10-29 生物探险有限公司 用于增强蛋白质表达的内部核糖体进入位点（IRES）、质粒载体和环状mRNA
WO2024151583A2 (en) 2023-01-09 2024-07-18 Flagship Pioneering Innovations Vii, Llc Vaccines and related methods
WO2024167885A1 (en) 2023-02-06 2024-08-15 Flagship Pioneering Innovations Vii, Llc Immunomodulatory compositions and related methods
EP4680276A1 (en) 2023-03-15 2026-01-21 Flagship Pioneering Innovations VI, LLC Immunogenic compositions and uses thereof
WO2024192420A1 (en) 2023-03-15 2024-09-19 Flagship Pioneering Innovations Vi, Llc Compositions comprising polyribonucleotides and uses thereof
CN117070564B (zh) * 2023-03-30 2024-05-10 安可来(重庆)生物医药科技有限公司 一种用于合成环形rna的质粒及其构建方法与一种环形rna及其体外合成方法
EP4698150A1 (en) 2023-04-19 2026-02-25 Sail Biomedicines, Inc. Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids
WO2024220712A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Vaccine compositions
WO2024220752A2 (en) 2023-04-19 2024-10-24 Sail Biomedicines, Inc. Rna therapeutic compositions
WO2024233308A2 (en) * 2023-05-05 2024-11-14 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2024236366A2 (en) * 2023-05-12 2024-11-21 Sekkei Bio Private Limited Design and method of generating scarless circular rna
TW202500164A (zh) * 2023-05-23 2025-01-01 北京大學 形成環形ｒｎａ的方法
WO2025006684A1 (en) 2023-06-28 2025-01-02 Flagship Pioneering Innovations Vi, Llc Circular polyribonucleotides encoding antifusogenic polypeptides
CN121752588A (zh) * 2023-08-29 2026-03-27 上海环码生物医药有限公司 编码vegf多肽的环状rna、制剂和使用方法
WO2025054282A1 (en) * 2023-09-06 2025-03-13 Massachusetts Institute Of Technology Engineered synthetic ires with improved and robust translation in circular rna
WO2025106915A1 (en) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 1 (glp-1) and uses thereof
WO2025106930A1 (en) 2023-11-17 2025-05-22 Sail Biomedicines, Inc. Circular polyribonucleotides encoding glucagon-like peptide 2 (glp-2) and uses thereof
WO2025111280A1 (en) * 2023-11-20 2025-05-30 Strand Therapeutics Inc. Circular rna synthesis
WO2025122609A1 (en) * 2023-12-04 2025-06-12 Strand Therapeutics Inc. Circular rna synthesis
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TW202545974A (zh) 2024-01-26 2025-12-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 免疫受體抑制蛋白及相關方法
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