JPWO2022181660A5 - - Google Patents
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- Publication number
- JPWO2022181660A5 JPWO2022181660A5 JP2023502465A JP2023502465A JPWO2022181660A5 JP WO2022181660 A5 JPWO2022181660 A5 JP WO2022181660A5 JP 2023502465 A JP2023502465 A JP 2023502465A JP 2023502465 A JP2023502465 A JP 2023502465A JP WO2022181660 A5 JPWO2022181660 A5 JP WO2022181660A5
- Authority
- JP
- Japan
- Prior art keywords
- vldl
- cell culture
- fatty liver
- substance
- test substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004113 cell culture Methods 0.000 claims 9
- 108010062497 VLDL Lipoproteins Proteins 0.000 claims 8
- 239000000126 substance Substances 0.000 claims 5
- 208000004930 Fatty Liver Diseases 0.000 claims 3
- 206010019708 Hepatic steatosis Diseases 0.000 claims 3
- 108010007622 LDL Lipoproteins Proteins 0.000 claims 3
- 102000007330 LDL Lipoproteins Human genes 0.000 claims 3
- 239000012228 culture supernatant Substances 0.000 claims 3
- 208000010706 fatty liver disease Diseases 0.000 claims 3
- 210000003494 hepatocyte Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 230000000370 effect on dyslipidemia Effects 0.000 claims 2
- 238000012216 screening Methods 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000004264 monolayer culture Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021030911 | 2021-02-26 | ||
| JP2021030911 | 2021-02-26 | ||
| PCT/JP2022/007494 WO2022181660A1 (ja) | 2021-02-26 | 2022-02-24 | スクリーニング方法に使用するためのヒト脂肪肝モデル細胞 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022181660A1 JPWO2022181660A1 (https=) | 2022-09-01 |
| JPWO2022181660A5 true JPWO2022181660A5 (https=) | 2023-07-13 |
| JP7449626B2 JP7449626B2 (ja) | 2024-03-14 |
Family
ID=83049072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023502465A Active JP7449626B2 (ja) | 2021-02-26 | 2022-02-24 | スクリーニング方法に使用するためのヒト脂肪肝モデル細胞 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20250263667A1 (https=) |
| EP (1) | EP4299720A4 (https=) |
| JP (1) | JP7449626B2 (https=) |
| CN (1) | CN116917462A (https=) |
| CA (1) | CA3211975A1 (https=) |
| WO (1) | WO2022181660A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023058657A1 (ja) * | 2021-10-04 | 2023-04-13 | 株式会社フェニックスバイオ | コレステロール不含の高比重リポタンパク質粒子 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3157984B2 (ja) | 1994-04-11 | 2001-04-23 | 科学技術振興事業団 | 初代培養肝細胞の継代培養系 |
| CA2146735C (en) | 1994-04-11 | 2007-02-20 | Chise Tateno | Liver parenchymal cells having clonal growth ability, method for obtaining same, method for subculturing same, and subculturing system of primary hepatocytes |
| JP3266766B2 (ja) | 1994-08-23 | 2002-03-18 | 科学技術振興事業団 | ローン性増殖能を有する肝実質細胞とその取得方法、並びにその継代培養方法 |
| JPH0915225A (ja) | 1995-04-28 | 1997-01-17 | Tosoh Corp | 血清リポタンパク質の分析方法 |
| JP3014322B2 (ja) | 1996-05-28 | 2000-02-28 | 科学技術振興事業団 | 小型肝細胞の培養方法 |
| JP3211941B2 (ja) | 1996-12-26 | 2001-09-25 | 科学技術振興事業団 | ヒト小型肝細胞の取得方法と、この細胞の初代培養および継代培養方法 |
| JP2002045087A (ja) | 2000-05-19 | 2002-02-12 | Japan Science & Technology Corp | キメラ動物 |
| JPWO2007052789A1 (ja) | 2005-11-04 | 2009-04-30 | 株式会社スカイライト・バイオテック | 大血管障害を判別するためのリポタンパク質の分析方法 |
| JP2007228962A (ja) | 2006-01-31 | 2007-09-13 | Hiroshima Industrial Promotion Organization | ヒト肝細胞キメララットの作製方法 |
| WO2008001614A1 (fr) | 2006-06-29 | 2008-01-03 | Hiroshima Industrial Promotion Organization | Modèle animalier de stéatohépatite non alcoolique et modèle animalier de stéatose hépatique |
| AU2012374750B2 (en) | 2012-03-27 | 2017-02-02 | National University Corporation Kumamoto University | Humanized mouse |
| KR102089477B1 (ko) * | 2012-08-31 | 2020-03-17 | 더 가버너스 오브 더 유니버시티 오브 알버타 | 1차 인간 간세포의 표현형을 갖는 세포를 생성하기 위한 방법 및 조성물 |
| JP2014204713A (ja) | 2013-03-21 | 2014-10-30 | 秋田県 | 肝細胞分化ステージを評価する新規測定法 |
| WO2016210163A1 (en) * | 2015-06-23 | 2016-12-29 | Colorado State University Research Foundation | Engineered model of fibrotic diseases |
| JP7039045B2 (ja) * | 2019-08-26 | 2022-03-22 | 株式会社フェニックスバイオ | ヒト脂肪肝モデル細胞 |
| JP7379934B2 (ja) | 2019-08-26 | 2023-11-15 | マツダ株式会社 | 車両の後部構造 |
-
2022
- 2022-02-24 WO PCT/JP2022/007494 patent/WO2022181660A1/ja not_active Ceased
- 2022-02-24 CA CA3211975A patent/CA3211975A1/en active Pending
- 2022-02-24 US US18/278,605 patent/US20250263667A1/en active Pending
- 2022-02-24 JP JP2023502465A patent/JP7449626B2/ja active Active
- 2022-02-24 CN CN202280017368.1A patent/CN116917462A/zh active Pending
- 2022-02-24 EP EP22759695.4A patent/EP4299720A4/en active Pending
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