JPWO2022145444A5 - - Google Patents
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- Publication number
- JPWO2022145444A5 JPWO2022145444A5 JP2022573099A JP2022573099A JPWO2022145444A5 JP WO2022145444 A5 JPWO2022145444 A5 JP WO2022145444A5 JP 2022573099 A JP2022573099 A JP 2022573099A JP 2022573099 A JP2022573099 A JP 2022573099A JP WO2022145444 A5 JPWO2022145444 A5 JP WO2022145444A5
- Authority
- JP
- Japan
- Prior art keywords
- glutamic acids
- glutamic
- ring
- atom
- aminocarbonylated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 235000013922 glutamic acid Nutrition 0.000 description 9
- 239000004220 glutamic acid Substances 0.000 description 9
- 150000002307 glutamic acids Chemical class 0.000 description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000003725 azepanyl group Chemical group 0.000 description 1
- 125000002393 azetidinyl group Chemical group 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- -1 dimethylaminocarbonyl Chemical group 0.000 description 1
- 125000003386 piperidinyl group Chemical group 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000010532 solid phase synthesis reaction Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020218595 | 2020-12-28 | ||
| PCT/JP2021/048743 WO2022145444A1 (ja) | 2020-12-28 | 2021-12-28 | アミノ酸の固相合成用樹脂への担持方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2022145444A1 JPWO2022145444A1 (https=) | 2022-07-07 |
| JPWO2022145444A5 true JPWO2022145444A5 (https=) | 2024-12-11 |
Family
ID=82260759
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022573099A Pending JPWO2022145444A1 (https=) | 2020-12-28 | 2021-12-28 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240067674A1 (https=) |
| EP (1) | EP4249496A4 (https=) |
| JP (1) | JPWO2022145444A1 (https=) |
| KR (1) | KR20230125807A (https=) |
| CN (1) | CN116547295A (https=) |
| WO (1) | WO2022145444A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| EP3878836B1 (en) | 2018-11-07 | 2025-07-23 | Chugai Seiyaku Kabushiki Kaisha | O-substituted serine derivative production method |
| EP3939962A4 (en) | 2019-03-15 | 2022-12-28 | Chugai Seiyaku Kabushiki Kaisha | PROCESS FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE |
| BR112022007535A2 (pt) | 2019-11-07 | 2022-07-12 | Chugai Pharmaceutical Co Ltd | Composto peptídico cíclico tendo ação inibitória de kras |
| EP4056580A4 (en) | 2019-11-07 | 2023-12-06 | Chugai Seiyaku Kabushiki Kaisha | METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID |
| US12312379B2 (en) | 2021-05-07 | 2025-05-27 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing cyclic compounds comprising N-substituted amino acid residues |
| JP7823181B2 (ja) | 2022-05-06 | 2026-03-03 | 中外製薬株式会社 | Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物 |
| JPWO2024096023A1 (https=) | 2022-11-01 | 2024-05-10 | ||
| WO2024143514A1 (ja) | 2022-12-28 | 2024-07-04 | 中外製薬株式会社 | 環状ペプチドの精製法及び製造法 |
| TW202523345A (zh) | 2023-09-28 | 2025-06-16 | 日商中外製藥股份有限公司 | 使用混合酸酐法的胜肽化合物的製造方法 |
| TW202535901A (zh) | 2023-12-27 | 2025-09-16 | 日商中外製藥股份有限公司 | 使用獨立型縮合劑的胜肽化合物的製造方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1648921A2 (en) * | 2003-06-26 | 2006-04-26 | Carlsberg A/S | Libraries containing heterocyclic organic molecules prepared through intramolecular formation of n-acyliminium ions |
| EP2595661A1 (en) * | 2010-07-22 | 2013-05-29 | Novo Nordisk Health Care AG | Growth hormone conjugates |
| US20140213759A1 (en) * | 2011-06-16 | 2014-07-31 | Lonza Braine S.A. | Process For Extraction Of Peptides And Its Application In Liquid Phase Peptide Synthesis |
| CN102643330B (zh) * | 2011-07-09 | 2018-10-19 | 广东医科大学 | 一种骨靶向药物天冬氨酸六肽丹参素的合成方法及其医疗用途 |
| TW202446781A (zh) | 2011-12-28 | 2024-12-01 | 日商中外製藥股份有限公司 | 胜肽化合物之製造方法 |
| GB201622029D0 (en) | 2016-12-22 | 2017-02-08 | Nederlands Inst Voor Ecologie (Nioo-Knaw) See Scientia Terrae Vzw Nordic Semiconductor Asa | Voltage sampling circuits |
| CN110869544B (zh) | 2017-06-09 | 2024-03-08 | 中外制药株式会社 | 膜透过性高的环状肽化合物及包含其的文库 |
| KR20250007021A (ko) | 2017-06-09 | 2025-01-13 | 추가이 세이야쿠 가부시키가이샤 | N-치환 아미노산을 포함하는 펩타이드의 합성 방법 |
| WO2020111238A1 (ja) | 2018-11-30 | 2020-06-04 | 中外製薬株式会社 | ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法 |
| WO2020122182A1 (ja) | 2018-12-12 | 2020-06-18 | 中外製薬株式会社 | 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法 |
-
2021
- 2021-12-28 CN CN202180083338.6A patent/CN116547295A/zh active Pending
- 2021-12-28 JP JP2022573099A patent/JPWO2022145444A1/ja active Pending
- 2021-12-28 WO PCT/JP2021/048743 patent/WO2022145444A1/ja not_active Ceased
- 2021-12-28 EP EP21915302.0A patent/EP4249496A4/en active Pending
- 2021-12-28 KR KR1020237024024A patent/KR20230125807A/ko active Pending
- 2021-12-28 US US18/269,334 patent/US20240067674A1/en active Pending
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