JP2022514079A5 - - Google Patents
Info
- Publication number
- JP2022514079A5 JP2022514079A5 JP2021535563A JP2021535563A JP2022514079A5 JP 2022514079 A5 JP2022514079 A5 JP 2022514079A5 JP 2021535563 A JP2021535563 A JP 2021535563A JP 2021535563 A JP2021535563 A JP 2021535563A JP 2022514079 A5 JP2022514079 A5 JP 2022514079A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- ethyl
- alkyl
- amino
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18214002 | 2018-12-19 | ||
| EP18214002.0 | 2018-12-19 | ||
| EP19187352.0 | 2019-07-19 | ||
| EP19187352 | 2019-07-19 | ||
| PCT/EP2019/086239 WO2020127685A1 (en) | 2018-12-19 | 2019-12-19 | Amino-acid anilides as small molecule modulators of il-17 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022514079A JP2022514079A (ja) | 2022-02-09 |
| JP2022514079A5 true JP2022514079A5 (https=) | 2022-10-21 |
| JP7515481B2 JP7515481B2 (ja) | 2024-07-12 |
Family
ID=69147641
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021535563A Active JP7515481B2 (ja) | 2018-12-19 | 2019-12-19 | Ｉｌ－１７の小分子調節物質としてのアミノ酸アニリド |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US11377425B1 (https=) |
| EP (1) | EP3897623B1 (https=) |
| JP (1) | JP7515481B2 (https=) |
| CN (1) | CN113164448A (https=) |
| AU (1) | AU2019410261B2 (https=) |
| BR (1) | BR112021010453A2 (https=) |
| CA (1) | CA3121719A1 (https=) |
| IL (1) | IL284071B2 (https=) |
| MX (1) | MX2021006421A (https=) |
| NZ (1) | NZ777871A (https=) |
| SG (1) | SG11202106444WA (https=) |
| TW (1) | TW202039473A (https=) |
| UA (1) | UA129589C2 (https=) |
| WO (1) | WO2020127685A1 (https=) |
| ZA (1) | ZA202103791B (https=) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202103642D0 (en) * | 2021-03-16 | 2021-04-28 | C4X Discovery Ltd | Therapeutic compounds |
| WO2017087885A1 (en) | 2015-11-19 | 2017-05-26 | Dana-Farber Cancer Institute, Inc. | Methods of identifying compounds that interfere with erg-driven misguidance of baf complexes in tmprss2-erg driven prostate cancers |
| US11497752B2 (en) | 2018-01-30 | 2022-11-15 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| AU2019224354A1 (en) * | 2018-02-22 | 2020-10-08 | Nippon Zoki Pharmaceutical Co., Ltd. | IL-17a activity inhibitor and use thereof |
| WO2020081588A1 (en) | 2018-10-17 | 2020-04-23 | Dana-Farber Cancer Institute, Inc. | Swi/snf family chromatin remodeling complexes and uses thereof |
| TWI752400B (zh) | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| CN113645971B (zh) * | 2019-01-29 | 2024-10-18 | 福宏治疗公司 | 化合物及其用途 |
| US12509453B2 (en) | 2019-01-29 | 2025-12-30 | Foghorn Therapeutics Inc. | BRM/BRG1 inhibitors and uses thereof |
| US12384776B2 (en) | 2019-01-29 | 2025-08-12 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| AU2021213811A1 (en) | 2020-01-29 | 2022-07-28 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| PE20230469A1 (es) | 2020-04-30 | 2023-03-14 | Janssen Pharmaceutica Nv | Imidazopiridazinas como moduladores de il-17 |
| US12383555B2 (en) | 2020-05-20 | 2025-08-12 | Foghorn Therapeutics Inc. | Methods of treating cancers |
| GB202103640D0 (en) * | 2021-03-16 | 2021-04-28 | C4X Discovery Ltd | Therapeutic compounds |
| EP4157828A1 (en) * | 2020-05-27 | 2023-04-05 | Sanofi | Il-17a modulators |
| CA3180084A1 (en) * | 2020-05-27 | 2021-12-02 | Barrie Phillip MARTIN | Il-17a modulators |
| BR112022025028A2 (pt) * | 2020-06-12 | 2023-01-31 | Leo Pharma As | Moduladores de molécula pequena de il-17 |
| CN113880766B (zh) * | 2020-07-04 | 2023-10-31 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| CA3184979A1 (en) | 2020-07-04 | 2022-01-13 | Jin Li | Immunomodulator |
| EP3943495A1 (en) | 2020-07-24 | 2022-01-26 | Leo Pharma A/S | Small molecule modulators of il-17 |
| PY2193476A (es) | 2020-11-02 | 2022-06-06 | Novartis Ag | Inhibidores de interleucina-17 |
| WO2022096411A1 (en) | 2020-11-09 | 2022-05-12 | UCB Biopharma SRL | Dicyclopropylmethyl derivatives as il-17 modulators |
| US20230399328A1 (en) * | 2020-11-09 | 2023-12-14 | UCB Biopharma SRL | Dicyclopropylmethyl derivatives as il-17 modulators |
| EP4259631A1 (en) | 2020-12-14 | 2023-10-18 | UCB Biopharma SRL | Imidazopyridazine derivatives as il-17 modulators |
| US12606553B2 (en) | 2021-03-09 | 2026-04-21 | Foghorn Therapeutics Inc. | Crystalline forms, compositions containing same, and methods of their use |
| AR126255A1 (es) | 2021-07-01 | 2023-10-04 | UCB Biopharma SRL | Derivados de imidazotriazina como moduladores de il-17 |
| MX2024000504A (es) | 2021-07-09 | 2024-04-05 | Dice Alpha Inc | Moduladores de il-17a basados en fenilacetamida y usos de los mismos. |
| WO2023025783A1 (en) | 2021-08-23 | 2023-03-02 | Leo Pharma A/S | Small molecule modulators of il-17 |
| CN113929598A (zh) * | 2021-11-24 | 2022-01-14 | 上海吉奉生物科技有限公司 | 一种（s）-2-叔丁氧羰基氨基-3-（4,4-二氟环己基）丙酸的合成方法 |
| WO2023111181A1 (en) | 2021-12-16 | 2023-06-22 | Leo Pharma A/S | Small molecule modulators of il-17 |
| KR20240157703A (ko) | 2022-02-25 | 2024-11-01 | 다이스 알파, 인크. | 디-시클로프로필 기재 il-17a 조정제 및 그의 용도 |
| WO2023166172A1 (en) | 2022-03-04 | 2023-09-07 | Leo Pharma A/S | Small molecule modulators of il-17 |
| JP2025513513A (ja) | 2022-04-25 | 2025-04-24 | ノバルティス アーゲー | Ｉｌ－１７阻害剤の結晶形態 |
| CN117279889B (zh) * | 2022-04-28 | 2025-04-25 | 深圳湾实验室 | 经取代的氟硫酸盐及其用途 |
| WO2023245032A2 (en) * | 2022-06-14 | 2023-12-21 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for treating pediatric autoimmune neuropsychiatric disorders |
| GB202210731D0 (en) | 2022-07-22 | 2022-09-07 | UCB Biopharma SRL | Therapeutic agents |
| EP4584259A1 (en) | 2022-09-09 | 2025-07-16 | Innovo Therapeutics, Inc. | Ck1alpha and dual ck1alpha / gspt1 degrading compounds |
| TW202430165A (zh) | 2022-12-02 | 2024-08-01 | 丹麥商理奧藥品公司 | Il-17之小分子調節劑 |
| WO2025008732A1 (en) * | 2023-07-03 | 2025-01-09 | Zydus Lifesciences Limited | Novel compounds as modulators of il17 |
| CN116840382B (zh) * | 2023-07-13 | 2025-08-08 | 北京市农产品质量安全中心 | 同时检测水产品中11种药物及代谢物残留量的方法 |
| WO2025104230A1 (en) | 2023-11-17 | 2025-05-22 | Sanofi | Benzoxazoles as modulators of il-17a |
| WO2025133234A1 (en) | 2023-12-22 | 2025-06-26 | Draupnir Bio Aps | Sortilin binders and bifunctional compounds thereof |
| WO2026067743A1 (zh) * | 2024-09-29 | 2026-04-02 | 江苏威凯尔医药科技股份有限公司 | 一种作为il-17调节剂的小分子化合物 |
| CN119192167B (zh) * | 2024-11-28 | 2025-03-21 | 英矽智能科技(上海)有限公司 | 一类抑制il-17的化合物 |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA48121C2 (uk) | 1993-11-04 | 2002-08-15 | Сінтекс (С.Ш.А.) Інк. | Інгібітори матричних металопротеаз і фармацетична композиція на їх основі |
| US6037472A (en) | 1993-11-04 | 2000-03-14 | Syntex (U.S.A.) Inc. | Matrix metalloprotease inhibitors |
| US6288091B1 (en) | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
| WO1997024343A1 (en) * | 1995-12-29 | 1997-07-10 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenyl thiazole derivatives with anti herpes virus properties |
| WO2000029399A1 (en) * | 1998-11-12 | 2000-05-25 | Boehringer Ingelheim (Canada) Ltd. | Antiherpes compounds |
| US20010044445A1 (en) * | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
| DE10019755A1 (de) | 2000-04-20 | 2001-11-08 | Bayer Ag | Neue Aminoaryl/cycloalkylcarbonsäuren als Integrinantagonisten |
| CA2448737C (en) | 2001-07-20 | 2010-06-01 | Boehringer Ingelheim (Canada) Ltd. | Viral polymerase inhibitors |
| DE10247226A1 (de) * | 2002-10-10 | 2004-04-22 | Merck Patent Gmbh | Heterocyclische Amide |
| DE10254336A1 (de) * | 2002-11-21 | 2004-06-03 | Merck Patent Gmbh | Carbonsäureamide |
| US7879795B2 (en) * | 2004-05-21 | 2011-02-01 | Mpex Pharmaceuticals, Inc. | Enhancement of tigecycline potency using efflux pump inhibitors |
| SG155229A1 (en) | 2004-11-09 | 2009-09-30 | Smithkline Beecham Corp | Glycogen phosphorylase inhibitor compounds and pharmaceutical compositions thereof |
| US8211919B2 (en) * | 2005-09-02 | 2012-07-03 | Astellas Pharma Inc. | Amide derivatives as rock inhibitors |
| WO2008001076A1 (en) | 2006-06-26 | 2008-01-03 | Ucb Pharma S.A. | Fused thiazole derivatives as kinase inhibitors |
| EP2114888B1 (en) | 2007-02-02 | 2010-11-10 | Pfizer Products Inc. | Tricyclic compounds and their use as glucocorticoid receptor modulators |
| CN101784516B (zh) * | 2007-06-13 | 2014-07-02 | 百时美施贵宝公司 | 作为凝血因子抑制剂的二肽类似物 |
| WO2011153588A1 (en) | 2010-06-10 | 2011-12-15 | Biota Scientific Management Pty Ltd | Viral polymerase inhibitors |
| EP2809660B1 (en) * | 2012-02-02 | 2016-01-20 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating il-17 |
| ES2657266T3 (es) | 2012-03-19 | 2018-03-02 | Academisch Medisch Centrum | Medios y procedimientos para la predicción de respuesta al tratamiento de la hepatitis B |
| CN103319367B (zh) * | 2012-03-23 | 2016-05-04 | 上海医药工业研究院 | 己酰胺衍生物、其制备方法、中间体和应用 |
| WO2013148677A1 (en) | 2012-03-26 | 2013-10-03 | University Of Florida Research Foundation, Inc. | Antimicrobial compounds and their use in treating plant disease |
| WO2014066726A2 (en) | 2012-10-26 | 2014-05-01 | Ensemble Therapeutics Corporation | Compounds for modulating il-17 |
| EP3019475A1 (en) | 2013-07-08 | 2016-05-18 | Bristol-Myers Squibb Company | Aryl amide kinase inhibitors |
| US20160244437A1 (en) * | 2013-09-26 | 2016-08-25 | Bayer Pharma Aktiengesellschaft | Substituted phenylalanine derivatives |
| CN106496071B (zh) * | 2015-09-07 | 2018-07-31 | 上海医药工业研究院 | 肉桂酰胺类化合物、其盐、中间体、制备方法及应用 |
| WO2017106426A1 (en) * | 2015-12-16 | 2017-06-22 | The Regents Of The University Of California | Fe nanoparticles with ppm contents of pd, cu and/or ni, reactions in water catalyzed by them |
| GB201709456D0 (en) | 2017-06-14 | 2017-07-26 | Ucb Biopharma Sprl | Therapeutic agents |
| CN107488148A (zh) * | 2017-06-26 | 2017-12-19 | 安徽省黄淮兽药有限公司 | 一种苯丙酰胺类杀虫剂及其制备方法 |
| US11472794B2 (en) | 2018-01-15 | 2022-10-18 | UCB Biopharma SRL | Fused imidazole derivatives as IL-17 modulators |
| US11497752B2 (en) | 2018-01-30 | 2022-11-15 | Foghorn Therapeutics Inc. | Compounds and uses thereof |
| CN110511213B (zh) | 2018-05-22 | 2021-10-19 | 成都先导药物开发股份有限公司 | 一种免疫调节剂 |
| EP3820567A1 (en) | 2018-07-12 | 2021-05-19 | UCB Biopharma SRL | Spirocyclic indane analogues as il-17 modulators |
| GB201820166D0 (en) | 2018-12-11 | 2019-01-23 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201820165D0 (en) | 2018-12-11 | 2019-01-23 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201820316D0 (en) | 2018-12-13 | 2019-01-30 | Bicyclerd Ltd | Bicyclic peptide ligands specific for IL-17 |
| TWI752400B (zh) | 2019-01-07 | 2022-01-11 | 美商美國禮來大藥廠 | Il-17a抑制劑 |
| CN113874080B (zh) | 2019-02-06 | 2024-09-27 | 戴斯阿尔法公司 | Il-17a调节剂及其用途 |
| GB201909194D0 (en) | 2019-06-26 | 2019-08-07 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201909191D0 (en) | 2019-06-26 | 2019-08-07 | Ucb Biopharma Sprl | Therapeutic agents |
| GB201909190D0 (en) | 2019-06-26 | 2019-08-07 | Ucb Biopharma Sprl | Therapeutic agents |
-
2019
- 2019-12-19 SG SG11202106444WA patent/SG11202106444WA/en unknown
- 2019-12-19 EP EP19832916.1A patent/EP3897623B1/en active Active
- 2019-12-19 JP JP2021535563A patent/JP7515481B2/ja active Active
- 2019-12-19 TW TW108146767A patent/TW202039473A/zh unknown
- 2019-12-19 NZ NZ777871A patent/NZ777871A/en unknown
- 2019-12-19 BR BR112021010453-4A patent/BR112021010453A2/pt unknown
- 2019-12-19 WO PCT/EP2019/086239 patent/WO2020127685A1/en not_active Ceased
- 2019-12-19 MX MX2021006421A patent/MX2021006421A/es unknown
- 2019-12-19 CN CN201980081538.0A patent/CN113164448A/zh active Pending
- 2019-12-19 IL IL284071A patent/IL284071B2/en unknown
- 2019-12-19 UA UAA202104162A patent/UA129589C2/uk unknown
- 2019-12-19 AU AU2019410261A patent/AU2019410261B2/en active Active
- 2019-12-19 CA CA3121719A patent/CA3121719A1/en active Pending
- 2019-12-19 US US16/765,143 patent/US11377425B1/en active Active
-
2021
- 2021-06-02 ZA ZA2021/03791A patent/ZA202103791B/en unknown
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