ATE288446T1 - Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartyl)- l-phenylalaninmethylester mittels oxazolidinonderivate - Google Patents

Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartyl)- l-phenylalaninmethylester mittels oxazolidinonderivate

Info

Publication number
ATE288446T1
ATE288446T1 AT01939127T AT01939127T ATE288446T1 AT E288446 T1 ATE288446 T1 AT E288446T1 AT 01939127 T AT01939127 T AT 01939127T AT 01939127 T AT01939127 T AT 01939127T AT E288446 T1 ATE288446 T1 AT E288446T1
Authority
AT
Austria
Prior art keywords
dimethylbutyl
methyl ester
aspartyl
alpha
production
Prior art date
Application number
AT01939127T
Other languages
English (en)
Inventor
Indra Prakash
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Application granted granted Critical
Publication of ATE288446T1 publication Critical patent/ATE288446T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Peptides Or Proteins (AREA)
AT01939127T 2000-05-19 2001-05-18 Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartyl)- l-phenylalaninmethylester mittels oxazolidinonderivate ATE288446T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20569400P 2000-05-19 2000-05-19
PCT/US2001/016144 WO2001090138A2 (en) 2000-05-19 2001-05-18 SYNTHESIS OF N-[N-(3,3-DIMETHYLBUTYL)-L-α-ASPARTYL]-L-PHENYLALANINE 1-METHYL ESTER USING OXAZOLIDINONE DERIVATIVES

Publications (1)

Publication Number Publication Date
ATE288446T1 true ATE288446T1 (de) 2005-02-15

Family

ID=22763255

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01939127T ATE288446T1 (de) 2000-05-19 2001-05-18 Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartyl)- l-phenylalaninmethylester mittels oxazolidinonderivate

Country Status (7)

Country Link
US (2) US6852875B2 (de)
EP (1) EP1284991B1 (de)
AT (1) ATE288446T1 (de)
AU (1) AU2001264679A1 (de)
DE (1) DE60108745T2 (de)
ES (1) ES2233647T3 (de)
WO (1) WO2001090138A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852875B2 (en) * 2000-05-19 2005-02-08 The Nutrasweet Co. Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives
US20100004977A1 (en) * 2006-09-05 2010-01-07 Innerscope Research Llc Method and System For Measuring User Experience For Interactive Activities
US8296172B2 (en) * 2006-09-05 2012-10-23 Innerscope Research, Inc. Method and system for determining audience response to a sensory stimulus
US9514436B2 (en) 2006-09-05 2016-12-06 The Nielsen Company (Us), Llc Method and system for predicting audience viewing behavior
KR101464397B1 (ko) 2007-03-29 2014-11-28 더 닐슨 컴퍼니 (유에스) 엘엘씨 마케팅 및 엔터테인먼트 효과의 분석
US8392253B2 (en) 2007-05-16 2013-03-05 The Nielsen Company (Us), Llc Neuro-physiology and neuro-behavioral based stimulus targeting system
US8533042B2 (en) 2007-07-30 2013-09-10 The Nielsen Company (Us), Llc Neuro-response stimulus and stimulus attribute resonance estimator
US8386313B2 (en) 2007-08-28 2013-02-26 The Nielsen Company (Us), Llc Stimulus placement system using subject neuro-response measurements
US8392255B2 (en) 2007-08-29 2013-03-05 The Nielsen Company (Us), Llc Content based selection and meta tagging of advertisement breaks
US20090083129A1 (en) 2007-09-20 2009-03-26 Neurofocus, Inc. Personalized content delivery using neuro-response priming data
US8151292B2 (en) 2007-10-02 2012-04-03 Emsense Corporation System for remote access to media, and reaction and survey data from viewers of the media
US20090133047A1 (en) 2007-10-31 2009-05-21 Lee Hans C Systems and Methods Providing Distributed Collection and Centralized Processing of Physiological Responses from Viewers
CN102015686B (zh) * 2008-03-21 2014-07-02 诺华股份有限公司 杂环化合物及其用途
US20100250325A1 (en) 2009-03-24 2010-09-30 Neurofocus, Inc. Neurological profiles for market matching and stimulus presentation
US10987015B2 (en) 2009-08-24 2021-04-27 Nielsen Consumer Llc Dry electrodes for electroencephalography
US20110106750A1 (en) 2009-10-29 2011-05-05 Neurofocus, Inc. Generating ratings predictions using neuro-response data
US9560984B2 (en) 2009-10-29 2017-02-07 The Nielsen Company (Us), Llc Analysis of controlled and automatic attention for introduction of stimulus material
WO2011133548A2 (en) 2010-04-19 2011-10-27 Innerscope Research, Inc. Short imagery task (sit) research method
US9292858B2 (en) 2012-02-27 2016-03-22 The Nielsen Company (Us), Llc Data collection system for aggregating biologically based measures in asynchronous geographically distributed public environments
US9451303B2 (en) 2012-02-27 2016-09-20 The Nielsen Company (Us), Llc Method and system for gathering and computing an audience's neurologically-based reactions in a distributed framework involving remote storage and computing
US9569986B2 (en) 2012-02-27 2017-02-14 The Nielsen Company (Us), Llc System and method for gathering and analyzing biometric user feedback for use in social media and advertising applications
CN104030942B (zh) * 2014-06-09 2016-08-24 浙江普洛医药科技有限公司 一种L-α-氨基丁酰胺盐酸盐的制备方法
US9936250B2 (en) 2015-05-19 2018-04-03 The Nielsen Company (Us), Llc Methods and apparatus to adjust content presented to an individual

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2697844B1 (fr) 1992-11-12 1995-01-27 Claude Nofre Nouveaux composés dérivés de dipeptides ou d'analogues dipeptidiques utiles comme agents édulcorants, leur procédé de préparation.
KR960009572B1 (ko) * 1992-12-22 1996-07-20 주식회사 미원 알파(α)-엘(L)-아스파르틸-엘(L)-페닐알라닌 메틸 에스테르의 제조방법
FR2719590B1 (fr) * 1994-05-09 1996-07-26 Claude Nofre Procédé perfectionné de préparation d'un composé dérivé de l'aspartame utile comme agent édulcorant.
CN1057773C (zh) * 1996-08-28 2000-10-25 中国科学院成都有机化学研究所 氨基－保护天冬甜肽的制备方法
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
NL1010063C2 (nl) 1998-09-10 2000-03-13 Holland Sweetener Co Werkwijze voor de bereiding van neotaam.
US6465677B1 (en) * 1998-11-19 2002-10-15 The Nutrasweet Company Method for the preparation of N-neohexyl-α-aspartyl-L-phenylalanine methyl ester from imidazolidin-4-one intermediates
AU1832500A (en) 1998-11-25 2000-06-19 Nutrasweet Company, The Purification of N-(N-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methyl ester via crystallization
US6077962A (en) 1998-12-24 2000-06-20 The Nutrasweet Company N-3, 3-dimethylbutyl-L-aspartic acid and esters thereof, the process of preparing the same, and the process for preparing N-(N-(3,3-dimethylbutyl) -α L-aspartyl)-L- phenylalanine 1-methyl ester therefrom
US6852875B2 (en) * 2000-05-19 2005-02-08 The Nutrasweet Co. Synthesis of N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester using oxazolidinone derivatives

Also Published As

Publication number Publication date
WO2001090138A2 (en) 2001-11-29
DE60108745T2 (de) 2005-07-07
US6852875B2 (en) 2005-02-08
US20020013490A1 (en) 2002-01-31
EP1284991A2 (de) 2003-02-26
US20050014967A1 (en) 2005-01-20
WO2001090138A3 (en) 2002-03-21
EP1284991B1 (de) 2005-02-02
AU2001264679A1 (en) 2001-12-03
DE60108745D1 (de) 2005-03-10
US7193103B2 (en) 2007-03-20
ES2233647T3 (es) 2005-06-16

Similar Documents

Publication Publication Date Title
ATE288446T1 (de) Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartyl)- l-phenylalaninmethylester mittels oxazolidinonderivate
EA199900690A1 (ru) Способ получения и очистки n-алкилированного производного аспартама
ATE270280T1 (de) Substituierte dipeptide zur förderung der sekretion von wachstumshormon
ATE266735T1 (de) Verfahren zur herstellung eines produktes, welches gegen bluthochdruck gerichtete tripeptide enthält
BR0315417A (pt) Derivados 1-acil-pirrolidina para o tratamento de infecções virais
DE50213989D1 (de) Verwendung von fumarsäureamiden
DE69941440D1 (de) Verwendung von C-Terminal modifizierter Oxamyl Dipeptide als Inhibitoren von der ice/ced-3 Familie von Cystein Proteasen
RU2008129096A (ru) Композиция для лечения волос
CY1106720T1 (el) Μεθοδος συνθεσεως εστερων της ν-[(s)-1-καρβοξυβουτυλ]-(s)-αλανινης και εφαρμογη στη συνθεση της υπερινδοπριλης
CN101384274B (zh) 包含具有非天然存在的氨基酸的肽的组合物及其使用方法
DE602004026514D1 (de) Orale Zusammensetzung aus Naturstoffen zum Erhalt der richtigen Hautfeuchtigkeit
ATE248806T1 (de) N-3, 3-dimethylbutyl-l-asparaginsäure und ihre ester, verfahren zur herstellung dieser und das verfahren um daraus n-(n-(3,3-dimethylbutyl)-l- alpha-aspartyl)-l-phenylalanin-1-methylester herzustellen
RU2005105321A (ru) Новый фермент, образующий пептид, микроорганизм, продуцирующий данный фермент, и способ синтеза дипептида с их применением
DE60111364D1 (de) Verfahren zur herstellung von n-[(s)-1-carboxybutyl]-(s) alanine estern und verwendung zur synthese von perindopril
DE69834929D1 (de) Verwendung eines organspezifischen ernährungmittels
DE69934712D1 (de) Verfahren zur herstellung von n-neohexyl-(a)-aspartyl-l-phenylalaninmethylester aus zwischenverbindungen die imidazolidin-4-on enthalten
DE60115106D1 (de) Herstellung von N-[N-(3,3-Dimethylbutyl)-l-Alpha-Aspartyl]-l-Phenylalanin-1-Methylester durch Verwendung vom l-Alpha-Aspartyl-l-Phenylalanin-1-Methylester als Vorläufer
ATE423106T1 (de) Verfahren zur kristallisation von n-(1(s)- ethoxycarbonyl-3-phenylpropyl)-l-alanin n- carbonsäureanhydrid
ATE282046T1 (de) Herstellung von n-(n-(3,3-dimethylbutyl)-l-alpha- aspartlyl)-l-phenylalaninmethylester mittels reduktiver alkylation und crystallisierung im wässrigen methanol
WO2000052019A3 (en) Crystallization products of neotame and methods for producing same
SE9800865D0 (sv) New Process
DE60015559D1 (de) Sentrin-spezifische menschliche protease senp1
GEP20094650B (en) Novel method for synthesizing esters of n-[(s)-1-carboxybutyl]-(s)-alanine and use thereof for synthesizing perindopril
Kim et al. Purification and Characterization of Bioactive Peptide Purified from Skate Skin
DE602004003508D1 (de) Aus pflanzen gewonnene peptide mit wasserreinigender und antimikrobieller wirkung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties