WO2000052019A3 - Crystallization products of neotame and methods for producing same - Google Patents

Crystallization products of neotame and methods for producing same Download PDF

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Publication number
WO2000052019A3
WO2000052019A3 PCT/US2000/005775 US0005775W WO0052019A3 WO 2000052019 A3 WO2000052019 A3 WO 2000052019A3 US 0005775 W US0005775 W US 0005775W WO 0052019 A3 WO0052019 A3 WO 0052019A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
neotame
producing same
crystallization products
products
Prior art date
Application number
PCT/US2000/005775
Other languages
French (fr)
Other versions
WO2000052019A2 (en
Inventor
Steven A Schroeder
Run Wang
Alan Myerson
Original Assignee
Nutrasweet Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nutrasweet Co filed Critical Nutrasweet Co
Priority to AU44491/00A priority Critical patent/AU4449100A/en
Publication of WO2000052019A2 publication Critical patent/WO2000052019A2/en
Publication of WO2000052019A3 publication Critical patent/WO2000052019A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/12—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30—Artificial sweetening agents
    • A23L27/31—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives
    • A23L27/32—Artificial sweetening agents containing amino acids, nucleotides, peptides or derivatives containing dipeptides or derivatives

Abstract

Disclosed are novel crystallization products of N-[N-(3, 3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester and methods for producing the same.
PCT/US2000/005775 1999-03-03 2000-03-03 Crystallization products of neotame and methods for producing same WO2000052019A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU44491/00A AU4449100A (en) 1999-03-03 2000-03-03 Novel crystallization products of neotame and methods for producing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12296999P 1999-03-03 1999-03-03
US60/122,969 1999-03-03

Publications (2)

Publication Number Publication Date
WO2000052019A2 WO2000052019A2 (en) 2000-09-08
WO2000052019A3 true WO2000052019A3 (en) 2001-01-11

Family

ID=22405963

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/005775 WO2000052019A2 (en) 1999-03-03 2000-03-03 Crystallization products of neotame and methods for producing same

Country Status (2)

Country Link
AU (1) AU4449100A (en)
WO (1) WO2000052019A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8791253B2 (en) 2006-06-19 2014-07-29 The Coca-Cola Company Rebaudioside A composition and method for purifying rebaudioside A
US9012626B2 (en) 2006-06-19 2015-04-21 The Coca-Cola Company Rebaudioside a composition and method for purifying rebaudioside a
US8030481B2 (en) 2007-05-21 2011-10-04 The Coca-Cola Company Stevioside polymorphic and amorphous forms, methods for their formulation, and uses
CN103342732B (en) * 2013-07-11 2014-12-03 济南诚汇双达化工有限公司 Crystallization method capable of improving flowability of Neotame
CN110563797A (en) * 2019-10-12 2019-12-13 山东奔月生物科技股份有限公司 Method for removing viscous components in neotame
CN114292310A (en) * 2021-12-30 2022-04-08 山东诚汇双达药业有限公司 Preparation method of neotame crystal form A

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514940A1 (en) * 1991-05-23 1992-11-25 Ajinomoto Co., Inc. Method of crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester
WO1994011391A1 (en) * 1992-11-12 1994-05-26 Claude Nofre Compounds useful as sweetening agents and process for their preparation
EP0600521A1 (en) * 1992-12-07 1994-06-08 Ajinomoto Co., Inc. Method for preparing alpha-L-aspartyl-L-phenylalanine
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
WO1999020648A1 (en) * 1997-10-23 1999-04-29 Ajinomoto Co., Inc. Process for the purification of aspartame derivative
WO2000015656A1 (en) * 1998-09-10 2000-03-23 Holland Sweetener Company V.O.F. Process for the preparation of neotame

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0514940A1 (en) * 1991-05-23 1992-11-25 Ajinomoto Co., Inc. Method of crystallizing alpha-L-aspartyl-L-phenylalanine methyl ester
WO1994011391A1 (en) * 1992-11-12 1994-05-26 Claude Nofre Compounds useful as sweetening agents and process for their preparation
EP0600521A1 (en) * 1992-12-07 1994-06-08 Ajinomoto Co., Inc. Method for preparing alpha-L-aspartyl-L-phenylalanine
US5728862A (en) * 1997-01-29 1998-03-17 The Nutrasweet Company Method for preparing and purifying an N-alkylated aspartame derivative
WO1999020648A1 (en) * 1997-10-23 1999-04-29 Ajinomoto Co., Inc. Process for the purification of aspartame derivative
WO2000015656A1 (en) * 1998-09-10 2000-03-23 Holland Sweetener Company V.O.F. Process for the preparation of neotame

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANAL. CHEM. (1999), 71(16), 3325-3331 *
CHEMICAL ABSTRACTS, vol. 131, no. 16, 18 October 1999, Columbus, Ohio, US; abstract no. 219055, PADDEN, BRIAN E. ET AL: "Comparison of Solid-State 13C NMR Spectroscopy and Powder X-ray Diffraction for Analyzing Mixtures of Polymorphs of Neotame" XP002140649 *
DONG, ZEDONG ET AL: "Crystal structure and physical characterization of neotame methanol solvate", J. CHEM. CRYSTALLOGR. (1999), 29(8), 967-975, XP000915724 *
GOODMAN, MURRAY ET AL: "X-ray structures of new dipeptide taste ligands", J. PEPT. SCI. (1998), 4(4), 229-238, XP000915709 *
MATTERN, RALPH-HEIKO ET AL: "Conformational analysis of potent sweet taste ligands by nuclear magnetic resonance, computer simulations and x-ray diffraction studies", J. PEPT. RES. (1997), 50(4), 286-299, XP000910240 *
PADDEN, BRIAN E. ET AL: "Comparison of Solid-State 13C NMR Spectroscopy and Powder X-ray Diffraction for Analyzing Mixtures of Polymorphs of Neotame", ANAL. CHEM. (1999), 71(16), 3325-3331, XP002140644 *
WINK, DONALD J. ET AL: "Neotame, an alkylated dipeptide and high intensity sweetener", ACTA CRYSTALLOGR., SECT. C: CRYST. STRUCT. COMMUN. (1999), C55(8), 1365-1368, XP000915725 *

Also Published As

Publication number Publication date
AU4449100A (en) 2000-09-21
WO2000052019A2 (en) 2000-09-08

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