CN116547295A - 氨基酸向固相合成用树脂的担载方法 - Google Patents

氨基酸向固相合成用树脂的担载方法 Download PDF

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Publication number
CN116547295A
CN116547295A CN202180083338.6A CN202180083338A CN116547295A CN 116547295 A CN116547295 A CN 116547295A CN 202180083338 A CN202180083338 A CN 202180083338A CN 116547295 A CN116547295 A CN 116547295A
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CN
China
Prior art keywords
solvent
resin
amino acid
group
dcm
Prior art date
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Pending
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CN202180083338.6A
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English (en)
Chinese (zh)
Inventor
关田宽子
小宫志央
团克矩
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Chugai Pharmaceutical Co Ltd
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Chugai Pharmaceutical Co Ltd
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Publication date
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Publication of CN116547295A publication Critical patent/CN116547295A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C07K1/062—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups for alpha- or omega-carboxy functions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN202180083338.6A 2020-12-28 2021-12-28 氨基酸向固相合成用树脂的担载方法 Pending CN116547295A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-218595 2020-12-28
JP2020218595 2020-12-28
PCT/JP2021/048743 WO2022145444A1 (ja) 2020-12-28 2021-12-28 アミノ酸の固相合成用樹脂への担持方法

Publications (1)

Publication Number Publication Date
CN116547295A true CN116547295A (zh) 2023-08-04

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ID=82260759

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CN202180083338.6A Pending CN116547295A (zh) 2020-12-28 2021-12-28 氨基酸向固相合成用树脂的担载方法

Country Status (6)

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US (1) US20240067674A1 (https=)
EP (1) EP4249496A4 (https=)
JP (1) JPWO2022145444A1 (https=)
KR (1) KR20230125807A (https=)
CN (1) CN116547295A (https=)
WO (1) WO2022145444A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
EP3878836B1 (en) 2018-11-07 2025-07-23 Chugai Seiyaku Kabushiki Kaisha O-substituted serine derivative production method
EP3939962A4 (en) 2019-03-15 2022-12-28 Chugai Seiyaku Kabushiki Kaisha PROCESS FOR PREPARING AN AROMATIC AMINO ACID DERIVATIVE
BR112022007535A2 (pt) 2019-11-07 2022-07-12 Chugai Pharmaceutical Co Ltd Composto peptídico cíclico tendo ação inibitória de kras
EP4056580A4 (en) 2019-11-07 2023-12-06 Chugai Seiyaku Kabushiki Kaisha METHOD FOR PRODUCING A PEPTIDE COMPOUND COMPRISING A STERICALLY HINDERED AMINO ACID
US12312379B2 (en) 2021-05-07 2025-05-27 Chugai Seiyaku Kabushiki Kaisha Methods for producing cyclic compounds comprising N-substituted amino acid residues
JP7823181B2 (ja) 2022-05-06 2026-03-03 中外製薬株式会社 Ｈｒａｓおよびｎｒａｓに対して選択的なｋｒａｓ阻害作用を有する環状化合物
JPWO2024096023A1 (https=) 2022-11-01 2024-05-10
WO2024143514A1 (ja) 2022-12-28 2024-07-04 中外製薬株式会社 環状ペプチドの精製法及び製造法
TW202523345A (zh) 2023-09-28 2025-06-16 日商中外製藥股份有限公司 使用混合酸酐法的胜肽化合物的製造方法
TW202535901A (zh) 2023-12-27 2025-09-16 日商中外製藥股份有限公司 使用獨立型縮合劑的胜肽化合物的製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1648921A2 (en) * 2003-06-26 2006-04-26 Carlsberg A/S Libraries containing heterocyclic organic molecules prepared through intramolecular formation of n-acyliminium ions
EP2595661A1 (en) * 2010-07-22 2013-05-29 Novo Nordisk Health Care AG Growth hormone conjugates
US20140213759A1 (en) * 2011-06-16 2014-07-31 Lonza Braine S.A. Process For Extraction Of Peptides And Its Application In Liquid Phase Peptide Synthesis
CN102643330B (zh) * 2011-07-09 2018-10-19 广东医科大学 一种骨靶向药物天冬氨酸六肽丹参素的合成方法及其医疗用途
TW202446781A (zh) 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
GB201622029D0 (en) 2016-12-22 2017-02-08 Nederlands Inst Voor Ecologie (Nioo-Knaw) See Scientia Terrae Vzw Nordic Semiconductor Asa Voltage sampling circuits
CN110869544B (zh) 2017-06-09 2024-03-08 中外制药株式会社 膜透过性高的环状肽化合物及包含其的文库
KR20250007021A (ko) 2017-06-09 2025-01-13 추가이 세이야쿠 가부시키가이샤 N-치환 아미노산을 포함하는 펩타이드의 합성 방법
WO2020111238A1 (ja) 2018-11-30 2020-06-04 中外製薬株式会社 ペプチド化合物、またはアミド化合物の脱保護法および固相反応における脱樹脂方法、並びにペプチド化合物の製造方法
WO2020122182A1 (ja) 2018-12-12 2020-06-18 中外製薬株式会社 分子内水素結合可能な官能基を有するアミノ酸とそれらのアミノ酸を含むペプチド化合物、およびそれらの製造方法

Also Published As

Publication number Publication date
KR20230125807A (ko) 2023-08-29
WO2022145444A1 (ja) 2022-07-07
US20240067674A1 (en) 2024-02-29
JPWO2022145444A1 (https=) 2022-07-07
EP4249496A1 (en) 2023-09-27
EP4249496A4 (en) 2024-11-13
TW202241921A (zh) 2022-11-01

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