JPWO2022120224A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2022120224A5
JPWO2022120224A5 JP2023534174A JP2023534174A JPWO2022120224A5 JP WO2022120224 A5 JPWO2022120224 A5 JP WO2022120224A5 JP 2023534174 A JP2023534174 A JP 2023534174A JP 2023534174 A JP2023534174 A JP 2023534174A JP WO2022120224 A5 JPWO2022120224 A5 JP WO2022120224A5
Authority
JP
Japan
Prior art keywords
agent
subject
use according
amino acid
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023534174A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024502708A5 (https=
JP2024502708A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/061883 external-priority patent/WO2022120224A1/en
Publication of JP2024502708A publication Critical patent/JP2024502708A/ja
Publication of JP2024502708A5 publication Critical patent/JP2024502708A5/ja
Publication of JPWO2022120224A5 publication Critical patent/JPWO2022120224A5/ja
Pending legal-status Critical Current

Links

JP2023534174A 2020-12-04 2021-12-03 インターロイキン-2作用物質を使用する方法 Pending JP2024502708A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063121726P 2020-12-04 2020-12-04
US63/121,726 2020-12-04
US202163283822P 2021-11-29 2021-11-29
US63/283,822 2021-11-29
PCT/US2021/061883 WO2022120224A1 (en) 2020-12-04 2021-12-03 Methods of using interleukin-2 agents

Publications (3)

Publication Number Publication Date
JP2024502708A JP2024502708A (ja) 2024-01-23
JP2024502708A5 JP2024502708A5 (https=) 2024-12-05
JPWO2022120224A5 true JPWO2022120224A5 (https=) 2024-12-05

Family

ID=79288050

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023534174A Pending JP2024502708A (ja) 2020-12-04 2021-12-03 インターロイキン-2作用物質を使用する方法

Country Status (9)

Country Link
US (2) US12098178B2 (https=)
EP (1) EP4255466A1 (https=)
JP (1) JP2024502708A (https=)
KR (1) KR20230129018A (https=)
AU (1) AU2021391924A1 (https=)
CA (1) CA3203977A1 (https=)
MX (1) MX2023006599A (https=)
TW (1) TW202237171A (https=)
WO (1) WO2022120224A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3147757A1 (en) 2019-07-26 2021-02-04 Visterra, Inc. Interleukin-2 agents and uses thereof
US20220365512A1 (en) * 2019-10-24 2022-11-17 Unm Rainforest Innovations Accelerated evolution and restructuring techniques for developing evolved structures
EP4255466A1 (en) 2020-12-04 2023-10-11 Visterra, Inc. Methods of using interleukin-2 agents
EP4651885A1 (en) * 2023-01-20 2025-11-26 F. Hoffmann-La Roche AG Recombinant fc domain - il2 variant polypeptides and combination therapy with membrane-anchored antigen binding polypeptides
WO2026067798A1 (zh) * 2024-09-30 2026-04-02 长春金赛药业有限责任公司 Pth复合物及其应用

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4908433A (en) 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Uses of interleukin-2
JPS6147500A (ja) 1984-08-15 1986-03-07 Res Dev Corp Of Japan キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en) 1984-08-27 1987-11-25 The Board Of Trustees Of The Leland Stanford Junior University Chimeric receptors by dna splicing and expression
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
JPS61134325A (ja) 1984-12-04 1986-06-21 Teijin Ltd ハイブリツド抗体遺伝子の発現方法
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
EP0262802A3 (en) 1986-09-01 1990-01-31 Takeda Chemical Industries, Ltd. Medicament for the treatment or improvement of rheumatoid arthritis or systemic lupus erythematosus
WO1988007089A1 (en) 1987-03-18 1988-09-22 Medical Research Council Altered antibodies
ATE243754T1 (de) 1987-05-21 2003-07-15 Micromet Ag Multifunktionelle proteine mit vorbestimmter zielsetzung
US5466447A (en) 1988-06-29 1995-11-14 Amgen Inc. Method for treating psoriasis
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
EP0436597B1 (en) 1988-09-02 1997-04-02 Protein Engineering Corporation Generation and selection of recombinant varied binding proteins
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
GB8905669D0 (en) 1989-03-13 1989-04-26 Celltech Ltd Modified antibodies
WO1991000906A1 (en) 1989-07-12 1991-01-24 Genetics Institute, Inc. Chimeric and transgenic animals capable of producing human antibodies
EP1690934A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
EP0585287B1 (en) 1990-07-10 1999-10-13 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
ATE300615T1 (de) 1990-08-29 2005-08-15 Genpharm Int Transgene mäuse fähig zur produktion heterologer antikörper
ATE352612T1 (de) 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
CA2405246A1 (en) 1990-12-03 1992-06-11 Genentech, Inc. Enrichment method for variant proteins with alterred binding properties
ATE241011T1 (de) 1991-02-27 2003-06-15 Micromet Ag Serin-reiche peptidlinker
US5525491A (en) 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
EP0575485A1 (en) 1991-03-01 1993-12-29 Dyax Corp. Process for the development of binding mini-proteins
DK0580737T3 (da) 1991-04-10 2004-11-01 Scripps Research Inst Heterodimere receptorbiblioteker ved anvendelse af phagemider
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
DE4122599C2 (de) 1991-07-08 1993-11-11 Deutsches Krebsforsch Phagemid zum Screenen von Antikörpern
US5229109A (en) 1992-04-14 1993-07-20 Board Of Regents, The University Of Texas System Low toxicity interleukin-2 analogues for use in immunotherapy
AU701578B2 (en) 1992-08-21 1999-02-04 Vrije Universiteit Brussel Immunoglobulins devoid of light chains
AU8124694A (en) 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DZ2788A1 (fr) 1998-05-15 2003-12-01 Bayer Ag Agonistes et antagonistes selectifs à IL-2.
US7371371B2 (en) 2001-08-13 2008-05-13 University Of Southern California Interleukin-2 mutants with reduced toxicity
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2005007121A2 (en) 2003-07-18 2005-01-27 Massachusetts Institute Of Technology Mutant interleukin-2(il-2) polypeptides
BRPI0508470A (pt) 2004-03-05 2007-07-31 Chiron Corp sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos
CA2656700A1 (en) 2006-07-06 2008-01-10 Merck Patent Gesellschaft Mit Beschraenkter Haftung Compositions and methods for enhancing the efficacy of il-2 mediated immune responses
WO2009061853A2 (en) 2007-11-05 2009-05-14 Massachusetts Institute Of Technology Mutant interleukin-2 (il-2) polypeptides
DE102008023820A1 (de) * 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
US20110200534A1 (en) 2008-08-21 2011-08-18 Industry-Academic Cooperation Foundation, Yonsei U T1-T2 Dual Modal MRI Contrast Agents
KR100873651B1 (ko) 2008-08-21 2008-12-11 김광한 잔디 식재기
WO2010021527A2 (ko) 2008-08-22 2010-02-25 Jung Tae Woo 영상에 포함된 객체를 색인하는 시스템 및 방법
KR101111286B1 (ko) 2008-08-22 2012-03-14 한국생산기술연구원 발포체, 이 발포체의 제조장치, 이 발포체를 이용한 발포금속의 제조방법 및 발포금속 제조장치
KR100996532B1 (ko) 2008-08-22 2010-11-24 주식회사 엠아이텍 탄소나노튜브 기반 바이오센서에서 링커와 스페이서를 이용한 민감도 증가 방법
WO2010021526A2 (en) 2008-08-22 2010-02-25 Lg Electronics Inc. A method for processing additional information related to an announced service or content in an nrt service and a broadcast receiver
CN103772268B (zh) 2008-08-22 2017-01-04 株式会社Lg化学 用于有机电子器件的材料以及使用所述材料的有机电子器件
WO2010021520A2 (ko) 2008-08-22 2010-02-25 엘지전자 주식회사 동기 채널 전송 방법
MX2011007647A (es) 2009-01-21 2011-09-01 Amgen Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes.
IT1395574B1 (it) 2009-09-14 2012-10-16 Guala Dispensing Spa Dispositivo di erogazione
CN102462837B (zh) 2010-11-19 2016-08-03 生物林格斯Ip有限公司 抗炎组合物
HUE029139T2 (hu) 2011-02-10 2017-02-28 Roche Glycart Ag Mutáns interleukin-2 polipeptidek
ES2811624T3 (es) 2011-03-11 2021-03-12 Hopitaux Paris Assist Publique Régimen de dosificación de IL-2 para tratar lupus eritematoso sistémico
KR102220006B1 (ko) 2011-03-11 2021-02-24 아시스땅스 퍼블리끄-오삐또 드 빠리 자가면역 - 관련 또는 염증성 장애를 치료하기 위한 저용량 il­2 의 용도
EA201892619A1 (ru) 2011-04-29 2019-04-30 Роше Гликарт Аг Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2
US9844582B2 (en) 2012-05-22 2017-12-19 Massachusetts Institute Of Technology Synergistic tumor treatment with extended-PK IL-2 and therapeutic agents
RS61391B1 (sr) 2012-06-08 2021-02-26 Alkermes Pharma Ireland Ltd Ligandi modifikovani primenom cirkularnog permutiranja kao agonisti i antagonisti
US20140044675A1 (en) 2012-08-10 2014-02-13 Roche Glycart Ag Interleukin-2 fusion proteins and uses thereof
US9580486B2 (en) 2013-03-14 2017-02-28 Amgen Inc. Interleukin-2 muteins for the expansion of T-regulatory cells
KR102042246B1 (ko) 2014-02-06 2019-11-28 에프. 호프만-라 로슈 아게 인터류킨-2 융합 단백질 및 이의 용도
GB2538666A (en) 2014-07-21 2016-11-23 Delinia Inc Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases
WO2016025385A1 (en) 2014-08-11 2016-02-18 Delinia, Inc. Modified il-2 variants that selectively activate regulatory t cells for the treatment of autoimmune diseases
MY188430A (en) 2015-04-10 2021-12-08 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells
PH12017501856B1 (en) 2015-04-10 2022-08-10 Amgen Inc Interleukin-2 muteins for the expansion of t-regulatory cells
RU2611685C2 (ru) 2015-07-20 2017-02-28 Илья Владимирович Духовлинов Гуманизированное моноклональное антитело, специфичное к синдекану-1
US20170204154A1 (en) 2016-01-20 2017-07-20 Delinia, Inc. Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases
KR102687530B1 (ko) 2016-05-04 2024-07-25 암젠 인크 T-조절 세포의 증식을 위한 인터류킨-2 뮤테인
SG11201900616UA (en) 2016-08-02 2019-02-27 Visterra Inc Engineered polypeptides and uses thereof
US11077172B2 (en) 2016-11-08 2021-08-03 Delinia, Inc. IL-2 variants for the treatment of psoriasis
CN116970059A (zh) 2016-12-22 2023-10-31 库尔生物制药有限公司 T细胞调节性多聚体多肽及其使用方法
EP3580230B1 (en) 2017-02-07 2026-04-22 Vib Vzw Immune-cell targeted bispecific chimeric proteins and uses thereof
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
US20210277085A1 (en) 2017-05-24 2021-09-09 Pandion Therapeutics, Inc. Targeted immunotolerance
WO2019112852A1 (en) 2017-12-06 2019-06-13 Pandion Therapeutics, Inc. Targeted immunotolerance
US20210017247A1 (en) 2017-07-03 2021-01-21 Torque Therapeutics, Inc. Fusion Molecules Targeting Immune Regulatory Cells and Uses Thereof
MX2020003783A (es) 2017-10-02 2021-01-08 Visterra Inc Moleculas de anticuerpo de cd138 y sus usos.
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
EP3720470A4 (en) 2017-12-06 2021-09-15 Pandion Operations, Inc. IL-2 MUTEINS AND THEIR USES
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
US11319355B2 (en) 2017-12-19 2022-05-03 Xencor, Inc. Engineered IL-2 Fc fusion proteins
MX2021000801A (es) 2018-07-24 2021-04-12 BioNTech SE Agonistas de il2.
JP7576027B2 (ja) * 2018-10-18 2024-10-30 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 誘電コポリマー材料
CA3147757A1 (en) 2019-07-26 2021-02-04 Visterra, Inc. Interleukin-2 agents and uses thereof
EP4255466A1 (en) 2020-12-04 2023-10-11 Visterra, Inc. Methods of using interleukin-2 agents
KR20230147072A (ko) 2021-01-20 2023-10-20 비스테라, 인크. 인터류킨-2 돌연변이체 및 이의 용도
WO2023102463A1 (en) 2021-12-01 2023-06-08 Visterra, Inc. Methods of using interleukin-2 agents
EP4475875A1 (en) 2022-02-11 2024-12-18 Visterra, Inc. Interleukin-2 muteins for the treatment of autoimmune diseases

Similar Documents

Publication Publication Date Title
CN1214043C (zh) 抗γ-干扰素的人化抗体
Bechman et al. Lymphodepletion strategies to potentiate adoptive T-cell immunotherapy–what are we doing; where are we going?
Songsivilai et al. Bispecific antibody: a tool for diagnosis and treatment of disease
US5824304A (en) Peripheralization of hematopoietic stem cells
US20200079853A1 (en) T regulatory cells and uses thereof
RU2019142600A (ru) Т-клеточные рецепторы
JP6240195B2 (ja) 抗cd26抗体とその利用
IL296966A (en) Chimeric receptors to flt3 and methods of use thereof
JPH07504808A (ja) Cdrをグラフトしたヒト化キメラt細胞抗体
PL170321B1 (pl) Sposób wytwarzania nowej czasteczki wiazacej CD25 PL PL PL PL PL PL
JPH06500229A (ja) 擬人化cdr移植抗icam―1抗体、その生産方法及びその使用
CN104774264B (zh) 抗人proBDNF单克隆抗体及其在疼痛中的作用
CN116120454A (zh) 人源化抗cd19抗体及其与嵌合抗原受体的用途
WO2016089610A1 (en) Bispecific antibody for cancer immunotherapy
JP2021514354A5 (https=)
JPWO2022120224A5 (https=)
Dreger et al. Myeloablative radiochemotherapy followed by reinfusion of purged autologous stem cells for Waldenström's macroglobulinaemia
Holstein Current Frontline Treatment of Multiple Myeloma.
CN118922208A (zh) 用于消耗患病造血干细胞的组合物和方法
JPH11501283A (ja) I型インターフェロンに対する中和活性を有する、インターフェロンレセプターに対するモノクローナル抗体を含んでなる医薬組成物
JPWO2023102463A5 (https=)
Lu et al. Tafasitamab for refractory/relapsed diffuse large B-cell lymphoma
JP2995860B2 (ja) 新規ペプチド
JP3024311B2 (ja) Il−2受容体重鎖に結合するポリペプチド
Waldmann The promiscuous IL-2/IL-15 receptor: a target for immunotherapy of HTLV-I-associated disorders