JPWO2022040259A5 - - Google Patents
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- Publication number
- JPWO2022040259A5 JPWO2022040259A5 JP2023512226A JP2023512226A JPWO2022040259A5 JP WO2022040259 A5 JPWO2022040259 A5 JP WO2022040259A5 JP 2023512226 A JP2023512226 A JP 2023512226A JP 2023512226 A JP2023512226 A JP 2023512226A JP WO2022040259 A5 JPWO2022040259 A5 JP WO2022040259A5
- Authority
- JP
- Japan
- Prior art keywords
- phenyl
- methylsulfonyl
- pyridine
- imidazo
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063067452P | 2020-08-19 | 2020-08-19 | |
| US63/067,452 | 2020-08-19 | ||
| PCT/US2021/046420 WO2022040259A1 (en) | 2020-08-19 | 2021-08-18 | Imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine derivatives as tlr9 inhibitors for the treatment of fibrosis |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2023538393A JP2023538393A (ja) | 2023-09-07 |
| JPWO2022040259A5 true JPWO2022040259A5 (https=) | 2024-08-26 |
| JP2023538393A5 JP2023538393A5 (https=) | 2024-08-26 |
| JP7813775B2 JP7813775B2 (ja) | 2026-02-13 |
Family
ID=77693624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023512226A Active JP7813775B2 (ja) | 2020-08-19 | 2021-08-18 | 線維症の処置のためのｔｌｒ９の阻害剤としてのイミダゾ［１，２－ａ］ピリジンおよび［１，２，４］トリアゾロ［１，５－ａ］ピリジン誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12486267B2 (https=) |
| EP (1) | EP4200297A1 (https=) |
| JP (1) | JP7813775B2 (https=) |
| KR (1) | KR20230053644A (https=) |
| CN (1) | CN116096717B (https=) |
| AR (1) | AR123281A1 (https=) |
| AU (1) | AU2021328575A1 (https=) |
| BR (1) | BR112023002737A2 (https=) |
| CA (1) | CA3190065A1 (https=) |
| IL (1) | IL300727A (https=) |
| MX (1) | MX2023001885A (https=) |
| TW (1) | TW202227432A (https=) |
| WO (1) | WO2022040259A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
| US20250163054A1 (en) * | 2022-02-18 | 2025-05-22 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds useful as inhibitors of tlr9 |
| CN120230100B (zh) * | 2025-05-30 | 2025-09-05 | 中国药科大学 | 一种咪唑并[1,2-a]吡嗪或咪唑并[1,2-a]吡啶类化合物及其医药用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006113458A1 (en) | 2005-04-15 | 2006-10-26 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of protein arginine methyl transferases |
| GB0602178D0 (en) | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
| CA2648652A1 (en) | 2006-04-04 | 2007-10-11 | Myriad Genetics, Inc. | Compounds for diseases and disorders |
| US20100035756A1 (en) | 2006-07-12 | 2010-02-11 | Syngenta Limited | Triazolophyridine derivatives as herbicides |
| EP2205085A1 (en) | 2007-09-25 | 2010-07-14 | Merck Sharp & Dohme Corp. | 2-aryl or heteroaryl indole derivatives |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| RU2012116207A (ru) | 2009-09-24 | 2013-10-27 | Ф.Хоффманн-Ля Рош Аг | Производные индола в качестве модуляторов crac |
| TWI617559B (zh) | 2010-12-22 | 2018-03-11 | 江蘇恆瑞醫藥股份有限公司 | ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物 |
| US9193724B2 (en) | 2011-09-22 | 2015-11-24 | Merck Sharp & Dohme Corp. | Triazolopyridyl compounds as aldosterone synthase inhibitors |
| WO2013092467A1 (en) | 2011-12-20 | 2013-06-27 | F. Hoffmann-La Roche Ag | 7-azaindole inhibitors of crac |
| US20130158066A1 (en) | 2011-12-20 | 2013-06-20 | Hoffmann-La Roche Inc. | 4-azaindole inhibitors of crac |
| WO2013156431A1 (en) | 2012-04-17 | 2013-10-24 | Syngenta Participations Ag | Pesticidally active pyridyl- and pyrimidyl- substituted thiazole and thiadiazole derivatives |
| EP2862853B1 (en) | 2012-06-18 | 2020-01-22 | Sumitomo Chemical Co., Ltd | Fused heterocyclic compound |
| CN105992766A (zh) | 2013-12-13 | 2016-10-05 | 武田药品工业株式会社 | 作为tlr抑制剂的吡咯并[3,2-c]吡啶衍生物 |
| EP3194394B1 (en) | 2014-09-16 | 2019-01-09 | Syngenta Participations AG | Pesticidally active tetracyclic derivatives with sulphur containing substituents |
| RU2729187C1 (ru) | 2015-09-29 | 2020-08-05 | Онкотерапи Сайенс, Инк. | Бициклическое соединение и его применение для ингибирования suv39h2 |
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| BR112019001270A2 (pt) | 2016-07-30 | 2019-04-30 | Bristol-Myers Squibb Company | compostos indol substituídos com dimetoxifenila como inibidores de tlr7, tlr8 ou tlr9 |
| JP7028861B2 (ja) | 2016-09-09 | 2022-03-02 | ブリストル－マイヤーズ スクイブ カンパニー | ピリジル置換のインドール化合物 |
| US11370794B2 (en) * | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| WO2018165112A1 (en) * | 2017-03-09 | 2018-09-13 | Oncotherapy Science, Inc. | Bicyclic compound and use thereof for inhibiting histone methyltransferase |
| KR102688509B1 (ko) | 2017-08-04 | 2024-07-24 | 브리스톨-마이어스 스큅 컴퍼니 | [1,2,4]트리아졸로[4,3-a]피리디닐 치환된 인돌 화합물 |
| WO2019028302A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR7 / 8/9 INHIBITORS |
| JP7265554B2 (ja) * | 2017-11-14 | 2023-04-26 | ブリストル－マイヤーズ スクイブ カンパニー | 置換インドール化合物 |
| KR102781141B1 (ko) | 2017-12-15 | 2025-03-13 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 인돌 에테르 화합물 |
| EA202091484A1 (ru) | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
| JP7304352B2 (ja) | 2017-12-19 | 2023-07-06 | ブリストル－マイヤーズ スクイブ カンパニー | ６－アザインドール化合物 |
| MX2020005462A (es) | 2017-12-19 | 2020-09-07 | Bristol Myers Squibb Co | Compuestos de indol sustituidos utiles como inhibidores de receptores tipo toll (tlr). |
| WO2019126081A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Amide substituted indole compounds useful as tlr inhibitors |
| KR102730859B1 (ko) | 2017-12-20 | 2024-11-15 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 및 헤테로아릴 치환된 인돌 화합물 |
| EP3728218B1 (en) | 2017-12-20 | 2021-12-01 | Bristol-Myers Squibb Company | Amino indole compounds useful as tlr inhibitors |
| SG11202005733QA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Diazaindole compounds |
| CN114981276B (zh) * | 2020-01-09 | 2024-09-27 | 住友化学株式会社 | 杂环化合物和含有其的有害节肢动物防除组合物 |
-
2021
- 2021-08-18 AU AU2021328575A patent/AU2021328575A1/en not_active Abandoned
- 2021-08-18 MX MX2023001885A patent/MX2023001885A/es unknown
- 2021-08-18 BR BR112023002737A patent/BR112023002737A2/pt not_active Application Discontinuation
- 2021-08-18 TW TW110130427A patent/TW202227432A/zh unknown
- 2021-08-18 KR KR1020237009016A patent/KR20230053644A/ko active Pending
- 2021-08-18 CN CN202180055737.1A patent/CN116096717B/zh active Active
- 2021-08-18 WO PCT/US2021/046420 patent/WO2022040259A1/en not_active Ceased
- 2021-08-18 CA CA3190065A patent/CA3190065A1/en active Pending
- 2021-08-18 EP EP21766786.4A patent/EP4200297A1/en active Pending
- 2021-08-18 AR ARP210102325A patent/AR123281A1/es not_active Application Discontinuation
- 2021-08-18 JP JP2023512226A patent/JP7813775B2/ja active Active
- 2021-08-18 IL IL300727A patent/IL300727A/en unknown
- 2021-08-18 US US18/042,036 patent/US12486267B2/en active Active
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