TW202227432A - 可做為tlr9抑制劑之經取代雙環化合物 - Google Patents
可做為tlr9抑制劑之經取代雙環化合物 Download PDFInfo
- Publication number
- TW202227432A TW202227432A TW110130427A TW110130427A TW202227432A TW 202227432 A TW202227432 A TW 202227432A TW 110130427 A TW110130427 A TW 110130427A TW 110130427 A TW110130427 A TW 110130427A TW 202227432 A TW202227432 A TW 202227432A
- Authority
- TW
- Taiwan
- Prior art keywords
- pyridine
- phenyl
- dimethoxyphenyl
- methylsulfonyl
- imidazo
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063067452P | 2020-08-19 | 2020-08-19 | |
| US63/067,452 | 2020-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202227432A true TW202227432A (zh) | 2022-07-16 |
Family
ID=77693624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110130427A TW202227432A (zh) | 2020-08-19 | 2021-08-18 | 可做為tlr9抑制劑之經取代雙環化合物 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US12486267B2 (https=) |
| EP (1) | EP4200297A1 (https=) |
| JP (1) | JP7813775B2 (https=) |
| KR (1) | KR20230053644A (https=) |
| CN (1) | CN116096717B (https=) |
| AR (1) | AR123281A1 (https=) |
| AU (1) | AU2021328575A1 (https=) |
| BR (1) | BR112023002737A2 (https=) |
| CA (1) | CA3190065A1 (https=) |
| IL (1) | IL300727A (https=) |
| MX (1) | MX2023001885A (https=) |
| TW (1) | TW202227432A (https=) |
| WO (1) | WO2022040259A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11807622B2 (en) | 2019-01-30 | 2023-11-07 | Insilico Medicine Ip Limited | TLR 9 inhibitors |
| US20250163054A1 (en) * | 2022-02-18 | 2025-05-22 | Bristol-Myers Squibb Company | Substituted bicyclic heteroaryl compounds useful as inhibitors of tlr9 |
| CN120230100B (zh) * | 2025-05-30 | 2025-09-05 | 中国药科大学 | 一种咪唑并[1,2-a]吡嗪或咪唑并[1,2-a]吡啶类化合物及其医药用途 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006113458A1 (en) | 2005-04-15 | 2006-10-26 | Bristol-Myers Squibb Company | Heterocyclic inhibitors of protein arginine methyl transferases |
| GB0602178D0 (en) | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
| CA2648652A1 (en) | 2006-04-04 | 2007-10-11 | Myriad Genetics, Inc. | Compounds for diseases and disorders |
| US20100035756A1 (en) | 2006-07-12 | 2010-02-11 | Syngenta Limited | Triazolophyridine derivatives as herbicides |
| EP2205085A1 (en) | 2007-09-25 | 2010-07-14 | Merck Sharp & Dohme Corp. | 2-aryl or heteroaryl indole derivatives |
| US8785489B2 (en) | 2008-10-17 | 2014-07-22 | Boehringer Ingelheim International Gmbh | Heteroaryl substituted indole compounds useful as MMP-13 inhibitors |
| RU2012116207A (ru) | 2009-09-24 | 2013-10-27 | Ф.Хоффманн-Ля Рош Аг | Производные индола в качестве модуляторов crac |
| TWI617559B (zh) | 2010-12-22 | 2018-03-11 | 江蘇恆瑞醫藥股份有限公司 | ２－芳基咪唑并［１，２－ｂ］嗒．２－苯基咪唑并［１，２－ａ］吡啶，和２－苯基咪唑并［１，２－ａ］吡衍生物 |
| US9193724B2 (en) | 2011-09-22 | 2015-11-24 | Merck Sharp & Dohme Corp. | Triazolopyridyl compounds as aldosterone synthase inhibitors |
| WO2013092467A1 (en) | 2011-12-20 | 2013-06-27 | F. Hoffmann-La Roche Ag | 7-azaindole inhibitors of crac |
| US20130158066A1 (en) | 2011-12-20 | 2013-06-20 | Hoffmann-La Roche Inc. | 4-azaindole inhibitors of crac |
| WO2013156431A1 (en) | 2012-04-17 | 2013-10-24 | Syngenta Participations Ag | Pesticidally active pyridyl- and pyrimidyl- substituted thiazole and thiadiazole derivatives |
| EP2862853B1 (en) | 2012-06-18 | 2020-01-22 | Sumitomo Chemical Co., Ltd | Fused heterocyclic compound |
| CN105992766A (zh) | 2013-12-13 | 2016-10-05 | 武田药品工业株式会社 | 作为tlr抑制剂的吡咯并[3,2-c]吡啶衍生物 |
| EP3194394B1 (en) | 2014-09-16 | 2019-01-09 | Syngenta Participations AG | Pesticidally active tetracyclic derivatives with sulphur containing substituents |
| RU2729187C1 (ru) | 2015-09-29 | 2020-08-05 | Онкотерапи Сайенс, Инк. | Бициклическое соединение и его применение для ингибирования suv39h2 |
| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| BR112019001270A2 (pt) | 2016-07-30 | 2019-04-30 | Bristol-Myers Squibb Company | compostos indol substituídos com dimetoxifenila como inibidores de tlr7, tlr8 ou tlr9 |
| JP7028861B2 (ja) | 2016-09-09 | 2022-03-02 | ブリストル－マイヤーズ スクイブ カンパニー | ピリジル置換のインドール化合物 |
| US11370794B2 (en) * | 2016-11-11 | 2022-06-28 | Dynavax Technologies Corporation | Toll-like receptor antagonist compounds and methods of use |
| WO2018165112A1 (en) * | 2017-03-09 | 2018-09-13 | Oncotherapy Science, Inc. | Bicyclic compound and use thereof for inhibiting histone methyltransferase |
| KR102688509B1 (ko) | 2017-08-04 | 2024-07-24 | 브리스톨-마이어스 스큅 컴퍼니 | [1,2,4]트리아졸로[4,3-a]피리디닐 치환된 인돌 화합물 |
| WO2019028302A1 (en) | 2017-08-04 | 2019-02-07 | Bristol-Myers Squibb Company | SUBSTITUTED INDOLE COMPOUNDS USEFUL AS TLR7 / 8/9 INHIBITORS |
| JP7265554B2 (ja) * | 2017-11-14 | 2023-04-26 | ブリストル－マイヤーズ スクイブ カンパニー | 置換インドール化合物 |
| KR102781141B1 (ko) | 2017-12-15 | 2025-03-13 | 브리스톨-마이어스 스큅 컴퍼니 | 치환된 인돌 에테르 화합물 |
| EA202091484A1 (ru) | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
| JP7304352B2 (ja) | 2017-12-19 | 2023-07-06 | ブリストル－マイヤーズ スクイブ カンパニー | ６－アザインドール化合物 |
| MX2020005462A (es) | 2017-12-19 | 2020-09-07 | Bristol Myers Squibb Co | Compuestos de indol sustituidos utiles como inhibidores de receptores tipo toll (tlr). |
| WO2019126081A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Amide substituted indole compounds useful as tlr inhibitors |
| KR102730859B1 (ko) | 2017-12-20 | 2024-11-15 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 및 헤테로아릴 치환된 인돌 화합물 |
| EP3728218B1 (en) | 2017-12-20 | 2021-12-01 | Bristol-Myers Squibb Company | Amino indole compounds useful as tlr inhibitors |
| SG11202005733QA (en) | 2017-12-20 | 2020-07-29 | Bristol Myers Squibb Co | Diazaindole compounds |
| CN114981276B (zh) * | 2020-01-09 | 2024-09-27 | 住友化学株式会社 | 杂环化合物和含有其的有害节肢动物防除组合物 |
-
2021
- 2021-08-18 AU AU2021328575A patent/AU2021328575A1/en not_active Abandoned
- 2021-08-18 MX MX2023001885A patent/MX2023001885A/es unknown
- 2021-08-18 BR BR112023002737A patent/BR112023002737A2/pt not_active Application Discontinuation
- 2021-08-18 TW TW110130427A patent/TW202227432A/zh unknown
- 2021-08-18 KR KR1020237009016A patent/KR20230053644A/ko active Pending
- 2021-08-18 CN CN202180055737.1A patent/CN116096717B/zh active Active
- 2021-08-18 WO PCT/US2021/046420 patent/WO2022040259A1/en not_active Ceased
- 2021-08-18 CA CA3190065A patent/CA3190065A1/en active Pending
- 2021-08-18 EP EP21766786.4A patent/EP4200297A1/en active Pending
- 2021-08-18 AR ARP210102325A patent/AR123281A1/es not_active Application Discontinuation
- 2021-08-18 JP JP2023512226A patent/JP7813775B2/ja active Active
- 2021-08-18 IL IL300727A patent/IL300727A/en unknown
- 2021-08-18 US US18/042,036 patent/US12486267B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP4200297A1 (en) | 2023-06-28 |
| CN116096717A (zh) | 2023-05-09 |
| WO2022040259A1 (en) | 2022-02-24 |
| US12486267B2 (en) | 2025-12-02 |
| CN116096717B (zh) | 2026-04-10 |
| IL300727A (en) | 2023-04-01 |
| KR20230053644A (ko) | 2023-04-21 |
| JP7813775B2 (ja) | 2026-02-13 |
| US20240067638A1 (en) | 2024-02-29 |
| BR112023002737A2 (pt) | 2023-03-14 |
| AU2021328575A1 (en) | 2023-03-16 |
| AR123281A1 (es) | 2022-11-16 |
| JP2023538393A (ja) | 2023-09-07 |
| CA3190065A1 (en) | 2022-02-24 |
| MX2023001885A (es) | 2023-03-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US12492188B2 (en) | 1H-benzo[D]imidazole derivatives as TLR9 inhibitors for the treatment of fibrosis | |
| JP2021507912A (ja) | ６−アザインドール化合物 | |
| US12590091B2 (en) | 1H-pyrrolo[3,2-C]pyridine and 1H-pyrrolo[2,3-C]pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis | |
| TW202227431A (zh) | 可做為tlr9抑制劑之經取代雜芳基化合物 | |
| US12486267B2 (en) | Imidazo[1,2-A]pyridine and [1,2,4]triazolo[1,5-A]pyridine derivatives as TLR9 inhibitors for the treatment of fibrosis | |
| EA050655B1 (ru) | Замещенные бициклические соединения, пригодные для применения в качестве ингибиторов tlr9 | |
| US20250177363A1 (en) | Substituted imidazopyridinyl compounds useful as inhibitors of tlr9 | |
| US20250163054A1 (en) | Substituted bicyclic heteroaryl compounds useful as inhibitors of tlr9 | |
| CN120282961A (zh) | 用作tlr9的抑制剂的取代的苯并咪唑化合物 | |
| CN118786130A (zh) | 可用作tlr9抑制剂的经取代的咪唑并吡啶基化合物 |