JPWO2021263131A5 - - Google Patents

Info

Publication number

JPWO2021263131A5

JPWO2021263131A5 JP2022580180A JP2022580180A JPWO2021263131A5 JP WO2021263131 A5 JPWO2021263131 A5 JP WO2021263131A5 JP 2022580180 A JP2022580180 A JP 2022580180A JP 2022580180 A JP2022580180 A JP 2022580180A JP WO2021263131 A5 JPWO2021263131 A5 JP WO2021263131A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

coronavirus

peptide

antigen

nucleic acid

Prior art date

2024-07-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 56
• 239000000427 antigen Substances 0.000 claims 40
• 102000036639 antigens Human genes 0.000 claims 40
• 108091007433 antigens Proteins 0.000 claims 40
• 241000711573 Coronaviridae Species 0.000 claims 39
• 108090000765 processed proteins & peptides Proteins 0.000 claims 32
• 108010061994 Coronavirus Spike Glycoprotein Proteins 0.000 claims 22
• 150000007523 nucleic acids Chemical group 0.000 claims 22
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 15
• OGQYPPBGSLZBEG-UHFFFAOYSA-N dimethyl(dioctadecyl)azanium Chemical compound CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC OGQYPPBGSLZBEG-UHFFFAOYSA-N 0.000 claims 14
• 108700002099 Coronavirus Nucleocapsid Proteins Proteins 0.000 claims 9
• 239000002202 Polyethylene glycol Substances 0.000 claims 6
• 125000003827 glycol group Chemical group 0.000 claims 6
• 229920001223 polyethylene glycol Polymers 0.000 claims 6
• 229920001184 polypeptide Polymers 0.000 claims 6
• 102000004196 processed proteins & peptides Human genes 0.000 claims 6
• 150000002632 lipids Chemical class 0.000 claims 5
• 238000000034 method Methods 0.000 claims 3
• 108020004707 nucleic acids Proteins 0.000 claims 3
• 102000039446 nucleic acids Human genes 0.000 claims 3
• 238000007920 subcutaneous administration Methods 0.000 claims 3
• 239000013638 trimer Substances 0.000 claims 3
• 102100035765 Angiotensin-converting enzyme 2 Human genes 0.000 claims 2
• 108090000975 Angiotensin-converting enzyme 2 Proteins 0.000 claims 2
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
• 238000005399 mechanical ventilation Methods 0.000 claims 2
• 239000002773 nucleotide Substances 0.000 claims 2
• 125000003729 nucleotide group Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 101000629318 Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein Proteins 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 150000004676 glycans Chemical class 0.000 claims 1
• UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical class O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 230000001939 inductive effect Effects 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 239000002777 nucleoside Substances 0.000 claims 1
• 125000003835 nucleoside group Chemical group 0.000 claims 1
• VQWNELVFHZRFIB-UHFFFAOYSA-N odn 1826 Chemical compound O=C1NC(=O)C(C)=CN1C(O1)CC(O)C1COP(O)(=O)OC1CC(N2C(NC(=O)C(C)=C2)=O)OC1COP(O)(=O)OC1CC(N2C3=C(C(NC(N)=N3)=O)N=C2)OC1COP(O)(=O)OC1CC(N2C(N=C(N)C=C2)=O)OC1COP(O)(=O)OC1CC(N2C3=NC=NC(N)=C3N=C2)OC1COP(O)(=O)OC1CC(N2C3=C(C(NC(N)=N3)=O)N=C2)OC1COP(O)(=O)OC1CC(N2C(NC(=O)C(C)=C2)=O)OC1COP(O)(=O)OC1CC(N2C(N=C(N)C=C2)=O)OC1COP(O)(=O)OC1CC(N2C(N=C(N)C=C2)=O)OC1COP(O)(=O)OC1CC(N2C(NC(=O)C(C)=C2)=O)OC1COP(O)(=O)OC(C(O1)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=O)OC2C(OC(C2)N2C3=C(C(NC(N)=N3)=O)N=C2)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C3=NC=NC(N)=C3N=C2)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(N=C(N)C=C2)=O)COP(O)(=O)OC2C(OC(C2)N2C(NC(=O)C(C)=C2)=O)COP(O)(O)=O)CC1N1C=C(C)C(=O)NC1=O VQWNELVFHZRFIB-UHFFFAOYSA-N 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 229920001282 polysaccharide Polymers 0.000 claims 1
• 239000005017 polysaccharide Substances 0.000 claims 1
• 102000004169 proteins and genes Human genes 0.000 claims 1
• 108090000623 proteins and genes Proteins 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1