JP2013505713A5 - - Google Patents
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- JP2013505713A5 JP2013505713A5 JP2012530319A JP2012530319A JP2013505713A5 JP 2013505713 A5 JP2013505713 A5 JP 2013505713A5 JP 2012530319 A JP2012530319 A JP 2012530319A JP 2012530319 A JP2012530319 A JP 2012530319A JP 2013505713 A5 JP2013505713 A5 JP 2013505713A5
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- chimeric polypeptide
- membrane
- polypeptide
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- 102000004196 processed proteins & peptides Human genes 0.000 claims 94
- 229920001184 polypeptide Polymers 0.000 claims 88
- 239000012528 membrane Substances 0.000 claims 34
- 210000001808 exosome Anatomy 0.000 claims 16
- 210000004027 cell Anatomy 0.000 claims 15
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
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- 239000012634 fragment Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
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- 206010028980 Neoplasm Diseases 0.000 claims 6
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- 241000894006 Bacteria Species 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 5
- 230000000890 antigenic effect Effects 0.000 claims 5
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- 102000039446 nucleic acids Human genes 0.000 claims 5
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- NRZWYNLTFLDQQX-UHFFFAOYSA-N p-tert-Amylphenol Chemical compound CCC(C)(C)C1=CC=C(O)C=C1 NRZWYNLTFLDQQX-UHFFFAOYSA-N 0.000 claims 3
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- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims 2
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
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- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 102000011931 Nucleoproteins Human genes 0.000 claims 1
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- 235000021314 Palmitic acid Nutrition 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
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- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
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- 102000036639 antigens Human genes 0.000 claims 1
- 235000003704 aspartic acid Nutrition 0.000 claims 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
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- 239000003795 chemical substances by application Substances 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 230000007547 defect Effects 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 235000014113 dietary fatty acids Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 210000002472 endoplasmic reticulum Anatomy 0.000 claims 1
- 125000004030 farnesyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])C([H])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 229930195729 fatty acid Natural products 0.000 claims 1
- 239000000194 fatty acid Substances 0.000 claims 1
- 150000004665 fatty acids Chemical class 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 238000010348 incorporation Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 230000002503 metabolic effect Effects 0.000 claims 1
- 229930182817 methionine Natural products 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 229940105132 myristate Drugs 0.000 claims 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims 1
- 210000004897 n-terminal region Anatomy 0.000 claims 1
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000028327 secretion Effects 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 210000004989 spleen cell Anatomy 0.000 claims 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 1
- TUNFSRHWOTWDNC-UHFFFAOYSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 1
- 241001430294 unidentified retrovirus Species 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR09/04576 | 2009-09-24 | ||
| FR0904576A FR2950350B1 (fr) | 2009-09-24 | 2009-09-24 | Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations |
| PCT/FR2010/052006 WO2011036416A1 (fr) | 2009-09-24 | 2010-09-23 | Nouveaux polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leurs utilisations |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013505713A JP2013505713A (ja) | 2013-02-21 |
| JP2013505713A5 true JP2013505713A5 (https=) | 2013-04-25 |
| JP5932647B2 JP5932647B2 (ja) | 2016-06-08 |
Family
ID=42107419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012530319A Active JP5932647B2 (ja) | 2009-09-24 | 2010-09-23 | エキソソームに結合した目的のポリペプチドの分泌を可能にする新規キメラポリヌクレオチド及びポリペプチド、並びにその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9611481B2 (https=) |
| EP (1) | EP2480672B8 (https=) |
| JP (1) | JP5932647B2 (https=) |
| CA (1) | CA2775151C (https=) |
| FR (1) | FR2950350B1 (https=) |
| WO (1) | WO2011036416A1 (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014237485A1 (en) * | 2013-03-15 | 2015-10-22 | Novavax, Inc. | Enhanced expression of picornavirus proteins |
| US10538570B2 (en) * | 2013-09-30 | 2020-01-21 | Northwestern University | Targeted and modular exosome loading system |
| PL228341B1 (pl) * | 2014-04-21 | 2018-03-30 | Bio Ventures Inst Spolka Z Ograniczona Odpowiedzialnoscia | Sposób uzyskiwania białka poliepitopowego oraz wektor DNA do realizacji tego sposobu |
| US10501733B2 (en) * | 2015-02-27 | 2019-12-10 | University Of Washington | Polypeptide assemblies and methods for the production thereof |
| US10702581B2 (en) | 2015-05-04 | 2020-07-07 | Ilias Biologics Inc. | Compositions containing protein loaded exosome and methods for preparing and delivering the same |
| JP2019528674A (ja) * | 2016-09-30 | 2019-10-17 | セレックス ライフ サイエンシズ，インコーポレーテッド | タンパク質をロードしたエキソソームを含む組成物、並びにその調製及び送達のための方法 |
| PT3672614T (pt) | 2018-11-16 | 2022-02-11 | Codiak Biosciences Inc | Vesículas extracelulares modificadas e suas utilizações |
| IT201900000651A1 (it) | 2019-01-16 | 2019-04-16 | Pastore Lucio | Tecnologia di trasferimento genico |
| KR20210141554A (ko) | 2019-03-21 | 2021-11-23 | 코디악 바이오사이언시즈, 인크. | 세포외 소포 접합체 및 이의 용도 |
| BR112021020668A2 (pt) | 2019-04-17 | 2022-01-11 | Codiak Biosciences Inc | Composições de exossomos e aav |
| WO2021045501A1 (ko) * | 2019-09-02 | 2021-03-11 | 경북대학교 산학협력단 | Il-2 표면 발현 세포외 소포체를 유효성분으로 포함하는 암 질환 예방 또는 치료용 조성물 |
| WO2021144363A1 (en) | 2020-01-14 | 2021-07-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Antigenic reactivity of a peptide mimicking the glycan loop of flaviviruses envelope protein |
| JP7562682B2 (ja) * | 2020-01-27 | 2024-10-07 | マントラ バイオ，インコーポレイテッド | キメラ小胞局在化部分を含む非天然発生の小胞、その産生方法、およびその使用 |
| EP4099984A4 (en) | 2020-02-05 | 2024-05-01 | Diadem Biotherapeutics Inc. | ARTIFICIAL SYNAPSES |
| WO2021184021A1 (en) | 2020-03-13 | 2021-09-16 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting pmp22 |
| EP4138907A4 (en) * | 2020-04-20 | 2024-08-21 | The General Hospital Corporation | IMMUNOGENIC COMPOSITION OF CORONAVIRUS WITH EPITOPES HAVING HIGH NETWORK SCORE |
| WO2021237100A1 (en) | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
| US20230295229A1 (en) * | 2020-08-11 | 2023-09-21 | Kyungpook National University Industry-Academic Cooperation Foundation | Peptide selectively binding to cancer cell-derived exosome, and uses thereof |
| EP3973985A1 (en) * | 2020-09-29 | 2022-03-30 | Ciloa | Extracellular vesicles harboring a spike protein, nucleic acids for producing the same, and method of immunizing a subject against sars-cov-2 using the same |
| CN113480666B (zh) * | 2021-08-13 | 2024-01-26 | 郑州伊美诺生物技术有限公司 | Ca153融合蛋白及其制备方法和ca153检测质控品或校准品 |
| WO2023222890A1 (en) | 2022-05-20 | 2023-11-23 | Ciloa | Reversible loading of proteins in the lumen of extracellular vesicles |
| EP4612190A2 (en) * | 2022-11-02 | 2025-09-10 | Pioneer Biolabs, LLC | Systems and methods for single cell detection of protein secretion |
| EP4719600A1 (en) * | 2023-06-05 | 2026-04-08 | Ciloa | Chimeric polypeptides, extracellular vesicles comprising the same, and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE512982T1 (de) | 2001-08-17 | 2011-07-15 | Exothera L L C | Verfahren und zusammensetzung zum gezielten einbringen in exosome |
| JP2005528091A (ja) | 2002-03-14 | 2005-09-22 | アノシス・インコーポレーテッド | Ｔ細胞由来小胞の機能化、および免疫原性医薬組成物を製造するためのその使用 |
| WO2004073319A2 (en) | 2003-02-14 | 2004-08-26 | Anosys, Inc. | Methods and compounds for raising antibodies and for screening antibody repertoires |
| FR2928926B1 (fr) * | 2008-03-18 | 2015-08-21 | Centre Nat Rech Scient | Polynucleotides et polypeptides chimeriques permettant la secretion d'un polypeptide d'interet en association avec des exosomes et leur utilisation pour la production de compositions immunogenes |
-
2009
- 2009-09-24 FR FR0904576A patent/FR2950350B1/fr active Active
-
2010
- 2010-09-23 WO PCT/FR2010/052006 patent/WO2011036416A1/fr not_active Ceased
- 2010-09-23 EP EP10769025.7A patent/EP2480672B8/fr active Active
- 2010-09-23 US US13/497,779 patent/US9611481B2/en active Active
- 2010-09-23 CA CA2775151A patent/CA2775151C/fr active Active
- 2010-09-23 JP JP2012530319A patent/JP5932647B2/ja active Active
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