JPWO2021212084A5 - - Google Patents
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- Publication number
- JPWO2021212084A5 JPWO2021212084A5 JP2022562646A JP2022562646A JPWO2021212084A5 JP WO2021212084 A5 JPWO2021212084 A5 JP WO2021212084A5 JP 2022562646 A JP2022562646 A JP 2022562646A JP 2022562646 A JP2022562646 A JP 2022562646A JP WO2021212084 A5 JPWO2021212084 A5 JP WO2021212084A5
- Authority
- JP
- Japan
- Prior art keywords
- igg
- modified
- constant domain
- feline
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000282324 Felis Species 0.000 claims 17
- 238000006467 substitution reaction Methods 0.000 claims 12
- 125000003275 alpha amino acid group Chemical group 0.000 claims 9
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 3
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063011491P | 2020-04-17 | 2020-04-17 | |
| US63/011,491 | 2020-04-17 | ||
| PCT/US2021/027839 WO2021212084A1 (en) | 2020-04-17 | 2021-04-16 | Feline antibody variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023522030A JP2023522030A (ja) | 2023-05-26 |
| JPWO2021212084A5 true JPWO2021212084A5 (https=) | 2024-04-22 |
| JP2023522030A5 JP2023522030A5 (https=) | 2024-04-22 |
Family
ID=75870744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022562646A Pending JP2023522030A (ja) | 2020-04-17 | 2021-04-16 | ネコ科動物抗体バリアント |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US20240067730A1 (https=) |
| EP (1) | EP4136109A1 (https=) |
| JP (1) | JP2023522030A (https=) |
| KR (1) | KR20230005158A (https=) |
| CN (1) | CN115667300A (https=) |
| AU (1) | AU2021257355A1 (https=) |
| BR (1) | BR112022020631A2 (https=) |
| CA (1) | CA3176434A1 (https=) |
| CL (2) | CL2022002856A1 (https=) |
| CO (1) | CO2022014684A2 (https=) |
| EC (1) | ECSP22080858A (https=) |
| IL (1) | IL297290A (https=) |
| MX (1) | MX2022012793A (https=) |
| PE (1) | PE20230348A1 (https=) |
| PH (1) | PH12022552743A1 (https=) |
| TW (1) | TW202204404A (https=) |
| WO (1) | WO2021212084A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112020002871A2 (pt) | 2017-08-15 | 2020-07-28 | Kindred Biosciences, Inc. | variantes fc de igg para uso veterinário |
| US11542333B2 (en) | 2019-01-03 | 2023-01-03 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
| US11434276B2 (en) | 2020-05-11 | 2022-09-06 | Invetx, Inc. | Polypeptides with altered binding to neonatal Fc receptor (FcRn) and methods of use |
| CN115702169A (zh) * | 2020-06-10 | 2023-02-14 | 株式会社梅花治疗 | 包含促红细胞生成素多肽的融合蛋白 |
| EP4178977A1 (en) | 2020-07-10 | 2023-05-17 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in felines and methods of use |
| AR123645A1 (es) * | 2020-09-29 | 2022-12-28 | Zoetis Services Llc | Variantes de anticuerpos felinos |
| WO2025166165A1 (en) * | 2024-02-01 | 2025-08-07 | Zoetis Services, Llc | Compositions and methods for modifying antibody effector functions |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US5698762A (en) | 1994-12-09 | 1997-12-16 | Dauerman; Leonard | Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons |
| US20030031671A1 (en) | 2001-08-01 | 2003-02-13 | Sydney Welt | Methods of treating colon cancer utilizing tumor-specific antibodies |
| KR20070057839A (ko) | 2004-08-19 | 2007-06-07 | 제넨테크, 인크. | 변경된 이펙터 기능을 갖는 폴리펩티드 변이체 |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| RU2529951C2 (ru) * | 2007-12-26 | 2014-10-10 | Ксенкор, Инк. | ВАРИАНТЫ Fc С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ C FcRn |
| US9505829B2 (en) | 2010-08-19 | 2016-11-29 | Zoetis Belgium S.A. | Anti-NGF antibodies and their use |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| EP2859018B1 (en) | 2012-06-06 | 2021-09-22 | Zoetis Services LLC | Caninized anti-ngf antibodies and methods thereof |
| WO2018156180A1 (en) * | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| CN113194984A (zh) * | 2018-10-18 | 2021-07-30 | 金德雷德生物科学股份有限公司 | 兽用的与新生儿Fc受体(FcRn)结合改变的Fc变体 |
| CN113227134A (zh) * | 2018-12-05 | 2021-08-06 | 株式会社梅花治疗 | 抗体的Fc区变体 |
-
2021
- 2021-04-16 WO PCT/US2021/027839 patent/WO2021212084A1/en not_active Ceased
- 2021-04-16 JP JP2022562646A patent/JP2023522030A/ja active Pending
- 2021-04-16 BR BR112022020631A patent/BR112022020631A2/pt unknown
- 2021-04-16 AU AU2021257355A patent/AU2021257355A1/en active Pending
- 2021-04-16 MX MX2022012793A patent/MX2022012793A/es unknown
- 2021-04-16 IL IL297290A patent/IL297290A/en unknown
- 2021-04-16 CN CN202180028968.3A patent/CN115667300A/zh active Pending
- 2021-04-16 PE PE2022002416A patent/PE20230348A1/es unknown
- 2021-04-16 KR KR1020227035858A patent/KR20230005158A/ko active Pending
- 2021-04-16 US US17/918,860 patent/US20240067730A1/en active Pending
- 2021-04-16 PH PH1/2022/552743A patent/PH12022552743A1/en unknown
- 2021-04-16 CA CA3176434A patent/CA3176434A1/en active Pending
- 2021-04-16 EP EP21724443.3A patent/EP4136109A1/en active Pending
- 2021-04-19 TW TW110113948A patent/TW202204404A/zh unknown
-
2022
- 2022-10-17 CL CL2022002856A patent/CL2022002856A1/es unknown
- 2022-10-17 EC ECSENADI202280858A patent/ECSP22080858A/es unknown
- 2022-10-18 CO CONC2022/0014684A patent/CO2022014684A2/es unknown
-
2023
- 2023-11-13 CL CL2023003376A patent/CL2023003376A1/es unknown
-
2024
- 2024-04-19 US US18/640,470 patent/US20250026834A1/en active Pending
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