JPWO2021212081A5 - - Google Patents
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- Publication number
- JPWO2021212081A5 JPWO2021212081A5 JP2022562645A JP2022562645A JPWO2021212081A5 JP WO2021212081 A5 JPWO2021212081 A5 JP WO2021212081A5 JP 2022562645 A JP2022562645 A JP 2022562645A JP 2022562645 A JP2022562645 A JP 2022562645A JP WO2021212081 A5 JPWO2021212081 A5 JP WO2021212081A5
- Authority
- JP
- Japan
- Prior art keywords
- igg
- molecule
- modified
- modified igg
- constant domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108060003951 Immunoglobulin Proteins 0.000 claims 8
- 102000018358 immunoglobulin Human genes 0.000 claims 8
- 241000282465 Canis Species 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 5
- 241000282472 Canis lupus familiaris Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 1
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 1
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 229960001230 asparagine Drugs 0.000 claims 1
- 235000009582 asparagine Nutrition 0.000 claims 1
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063011453P | 2020-04-17 | 2020-04-17 | |
| US63/011,453 | 2020-04-17 | ||
| PCT/US2021/027836 WO2021212081A1 (en) | 2020-04-17 | 2021-04-16 | Canine antibody variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023522029A JP2023522029A (ja) | 2023-05-26 |
| JP2023522029A5 JP2023522029A5 (https=) | 2024-04-19 |
| JPWO2021212081A5 true JPWO2021212081A5 (https=) | 2024-04-19 |
Family
ID=75888187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022562645A Pending JP2023522029A (ja) | 2020-04-17 | 2021-04-16 | イヌ科動物抗体バリアント |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20230242635A1 (https=) |
| EP (1) | EP4136106A1 (https=) |
| JP (1) | JP2023522029A (https=) |
| KR (1) | KR20230005156A (https=) |
| CN (1) | CN115996949A (https=) |
| AU (1) | AU2021256056A1 (https=) |
| BR (1) | BR112022020944A2 (https=) |
| CA (1) | CA3175921A1 (https=) |
| CL (2) | CL2022002857A1 (https=) |
| CO (1) | CO2022014695A2 (https=) |
| EC (1) | ECSP22080846A (https=) |
| IL (1) | IL297287A (https=) |
| MX (1) | MX2022012866A (https=) |
| PE (1) | PE20230108A1 (https=) |
| PH (1) | PH12022552742A1 (https=) |
| TW (1) | TW202204403A (https=) |
| WO (1) | WO2021212081A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| BR112020002871A2 (pt) | 2017-08-15 | 2020-07-28 | Kindred Biosciences, Inc. | variantes fc de igg para uso veterinário |
| US11542333B2 (en) | 2019-01-03 | 2023-01-03 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
| US11434276B2 (en) | 2020-05-11 | 2022-09-06 | Invetx, Inc. | Polypeptides with altered binding to neonatal Fc receptor (FcRn) and methods of use |
| EP4178977A1 (en) | 2020-07-10 | 2023-05-17 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in felines and methods of use |
| IL301413A (en) * | 2020-09-28 | 2023-05-01 | Zoetis Services Llc | Canine antibody variants |
| KR20250026186A (ko) * | 2022-06-21 | 2025-02-25 | 조에티스 서비시즈 엘엘씨 | 갯과 항체 돌연변이체 |
| JP2026508096A (ja) | 2023-01-20 | 2026-03-10 | ゾエティス・サービシーズ・ユーケー・リミテッド | 治療抗体 |
| WO2025166165A1 (en) * | 2024-02-01 | 2025-08-07 | Zoetis Services, Llc | Compositions and methods for modifying antibody effector functions |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US5698762A (en) | 1994-12-09 | 1997-12-16 | Dauerman; Leonard | Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons |
| US20030031671A1 (en) | 2001-08-01 | 2003-02-13 | Sydney Welt | Methods of treating colon cancer utilizing tumor-specific antibodies |
| KR20070057839A (ko) | 2004-08-19 | 2007-06-07 | 제넨테크, 인크. | 변경된 이펙터 기능을 갖는 폴리펩티드 변이체 |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US9505829B2 (en) | 2010-08-19 | 2016-11-29 | Zoetis Belgium S.A. | Anti-NGF antibodies and their use |
| RS61723B1 (sr) * | 2011-02-04 | 2021-05-31 | Zoetis Services Llc | Imunogenične bordetella bronchiseptica kompozicije |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| EP2859018B1 (en) | 2012-06-06 | 2021-09-22 | Zoetis Services LLC | Caninized anti-ngf antibodies and methods thereof |
| CN114773470A (zh) * | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| KR20230079500A (ko) * | 2015-09-18 | 2023-06-07 | 추가이 세이야쿠 가부시키가이샤 | Il-8에 결합하는 항체 및 그의 사용 |
| WO2017186928A1 (en) * | 2016-04-29 | 2017-11-02 | Curevac Ag | Rna encoding an antibody |
| TWI693940B (zh) * | 2016-08-05 | 2020-05-21 | 日商中外製藥股份有限公司 | Ｉｌ-８相關疾病之治療用或預防用組成物 |
| WO2018073185A1 (en) * | 2016-10-17 | 2018-04-26 | Vetoquinol Sa | Modified antibody constant region |
| WO2018156180A1 (en) * | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| CN113194984A (zh) * | 2018-10-18 | 2021-07-30 | 金德雷德生物科学股份有限公司 | 兽用的与新生儿Fc受体(FcRn)结合改变的Fc变体 |
| US11542333B2 (en) * | 2019-01-03 | 2023-01-03 | Invetx, Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
| US20220169740A1 (en) * | 2019-03-20 | 2022-06-02 | Kindred Biosciences, Inc. | NGF Antagonists for Medical Use |
| IL301413A (en) * | 2020-09-28 | 2023-05-01 | Zoetis Services Llc | Canine antibody variants |
| WO2022165067A2 (en) * | 2021-01-28 | 2022-08-04 | Zoetis Services Llc | Mutations in canine antibody constant regions |
-
2021
- 2021-04-16 CN CN202180028973.4A patent/CN115996949A/zh active Pending
- 2021-04-16 EP EP21724863.2A patent/EP4136106A1/en active Pending
- 2021-04-16 JP JP2022562645A patent/JP2023522029A/ja active Pending
- 2021-04-16 IL IL297287A patent/IL297287A/en unknown
- 2021-04-16 MX MX2022012866A patent/MX2022012866A/es unknown
- 2021-04-16 PE PE2022002420A patent/PE20230108A1/es unknown
- 2021-04-16 CA CA3175921A patent/CA3175921A1/en active Pending
- 2021-04-16 AU AU2021256056A patent/AU2021256056A1/en active Pending
- 2021-04-16 KR KR1020227035765A patent/KR20230005156A/ko active Pending
- 2021-04-16 BR BR112022020944A patent/BR112022020944A2/pt unknown
- 2021-04-16 US US17/918,853 patent/US20230242635A1/en active Pending
- 2021-04-16 WO PCT/US2021/027836 patent/WO2021212081A1/en not_active Ceased
- 2021-04-16 PH PH1/2022/552742A patent/PH12022552742A1/en unknown
- 2021-04-19 TW TW110113947A patent/TW202204403A/zh unknown
-
2022
- 2022-10-17 EC ECSENADI202280846A patent/ECSP22080846A/es unknown
- 2022-10-17 CL CL2022002857A patent/CL2022002857A1/es unknown
- 2022-10-18 CO CONC2022/0014695A patent/CO2022014695A2/es unknown
-
2023
- 2023-11-13 CL CL2023003377A patent/CL2023003377A1/es unknown
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