JPWO2022072446A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2022072446A5 JPWO2022072446A5 JP2023519633A JP2023519633A JPWO2022072446A5 JP WO2022072446 A5 JPWO2022072446 A5 JP WO2022072446A5 JP 2023519633 A JP2023519633 A JP 2023519633A JP 2023519633 A JP2023519633 A JP 2023519633A JP WO2022072446 A5 JPWO2022072446 A5 JP WO2022072446A5
- Authority
- JP
- Japan
- Prior art keywords
- igg
- modified
- amino acid
- substitution
- modified igg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000006467 substitution reaction Methods 0.000 claims 16
- 241000282324 Felis Species 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 11
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 4
- 125000000539 amino acid group Chemical group 0.000 claims 4
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 4
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 2
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 241000282326 Felis catus Species 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063084693P | 2020-09-29 | 2020-09-29 | |
| US63/084,693 | 2020-09-29 | ||
| PCT/US2021/052579 WO2022072446A1 (en) | 2020-09-29 | 2021-09-29 | Feline antibody variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023542737A JP2023542737A (ja) | 2023-10-11 |
| JP2023542737A5 JP2023542737A5 (https=) | 2024-10-02 |
| JPWO2022072446A5 true JPWO2022072446A5 (https=) | 2024-10-02 |
Family
ID=78599139
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023519633A Pending JP2023542737A (ja) | 2020-09-29 | 2021-09-29 | ネコ科動物抗体バリアント |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP4221744A1 (https=) |
| JP (1) | JP2023542737A (https=) |
| KR (1) | KR20230091914A (https=) |
| CN (1) | CN116457369A (https=) |
| AR (1) | AR123645A1 (https=) |
| AU (1) | AU2021352395A1 (https=) |
| CA (1) | CA3195049A1 (https=) |
| CL (2) | CL2023000914A1 (https=) |
| CO (1) | CO2023004107A2 (https=) |
| EC (1) | ECSP23030307A (https=) |
| IL (1) | IL301414A (https=) |
| MX (1) | MX2023003694A (https=) |
| PE (1) | PE20240110A1 (https=) |
| TW (3) | TWI880316B (https=) |
| WO (1) | WO2022072446A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR123645A1 (es) | 2020-09-29 | 2022-12-28 | Zoetis Services Llc | Variantes de anticuerpos felinos |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6284471B1 (en) | 1991-03-18 | 2001-09-04 | New York University Medical Center | Anti-TNFa antibodies and assays employing anti-TNFa antibodies |
| US5698762A (en) | 1994-12-09 | 1997-12-16 | Dauerman; Leonard | Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons |
| US20030031671A1 (en) | 2001-08-01 | 2003-02-13 | Sydney Welt | Methods of treating colon cancer utilizing tumor-specific antibodies |
| KR20070057839A (ko) | 2004-08-19 | 2007-06-07 | 제넨테크, 인크. | 변경된 이펙터 기능을 갖는 폴리펩티드 변이체 |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US8546543B2 (en) | 2004-11-12 | 2013-10-01 | Xencor, Inc. | Fc variants that extend antibody half-life |
| DK1817340T3 (da) | 2004-11-12 | 2012-08-13 | Xencor Inc | Fc-varianter med ændret binding til fcrn |
| RU2529951C2 (ru) * | 2007-12-26 | 2014-10-10 | Ксенкор, Инк. | ВАРИАНТЫ Fc С ИЗМЕНЕННЫМ СВЯЗЫВАНИЕМ C FcRn |
| US9505829B2 (en) | 2010-08-19 | 2016-11-29 | Zoetis Belgium S.A. | Anti-NGF antibodies and their use |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| EP2859018B1 (en) | 2012-06-06 | 2021-09-22 | Zoetis Services LLC | Caninized anti-ngf antibodies and methods thereof |
| WO2019113123A1 (en) * | 2017-12-04 | 2019-06-13 | Precithera, Inc. | TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING |
| CN113194984A (zh) * | 2018-10-18 | 2021-07-30 | 金德雷德生物科学股份有限公司 | 兽用的与新生儿Fc受体(FcRn)结合改变的Fc变体 |
| CN113227134A (zh) * | 2018-12-05 | 2021-08-06 | 株式会社梅花治疗 | 抗体的Fc区变体 |
| WO2021212084A1 (en) * | 2020-04-17 | 2021-10-21 | Zoetis Services Llc | Feline antibody variants |
| AR123645A1 (es) | 2020-09-29 | 2022-12-28 | Zoetis Services Llc | Variantes de anticuerpos felinos |
-
2021
- 2021-09-29 AR ARP210102710A patent/AR123645A1/es unknown
- 2021-09-29 EP EP21806456.6A patent/EP4221744A1/en not_active Withdrawn
- 2021-09-29 EP EP25199779.7A patent/EP4711383A3/en active Pending
- 2021-09-29 CN CN202180077397.2A patent/CN116457369A/zh active Pending
- 2021-09-29 JP JP2023519633A patent/JP2023542737A/ja active Pending
- 2021-09-29 IL IL301414A patent/IL301414A/en unknown
- 2021-09-29 TW TW112132477A patent/TWI880316B/zh active
- 2021-09-29 CA CA3195049A patent/CA3195049A1/en active Pending
- 2021-09-29 TW TW110136252A patent/TWI814094B/zh active
- 2021-09-29 TW TW114113296A patent/TW202545990A/zh unknown
- 2021-09-29 MX MX2023003694A patent/MX2023003694A/es unknown
- 2021-09-29 PE PE2023001243A patent/PE20240110A1/es unknown
- 2021-09-29 WO PCT/US2021/052579 patent/WO2022072446A1/en not_active Ceased
- 2021-09-29 KR KR1020237014648A patent/KR20230091914A/ko active Pending
- 2021-09-29 AU AU2021352395A patent/AU2021352395A1/en active Pending
-
2023
- 2023-03-29 CL CL2023000914A patent/CL2023000914A1/es unknown
- 2023-03-29 CO CONC2023/0004107A patent/CO2023004107A2/es unknown
- 2023-04-25 EC ECSENADI202330307A patent/ECSP23030307A/es unknown
-
2024
- 2024-03-18 CL CL2024000789A patent/CL2024000789A1/es unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7140861B2 (ja) | ヘテロ二量体多重特異性抗体フォーマット | |
| CN110382529B (zh) | 工程化的异源二聚体蛋白质 | |
| US10316059B2 (en) | Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography | |
| JP2020506898A5 (https=) | ||
| CN110520445B (zh) | 抗pd-l1/抗pd-1天然抗体结构样异源二聚体形式双特异抗体及其制备 | |
| KR102247704B1 (ko) | 항 pd-1/항 her2 천연항체 구조 형태의 헤테로다이머 계의 이중특이성 항체 및 그 제조방법 | |
| JP2017046720A (ja) | 操作されたヘテロ二量体タンパク質ドメイン | |
| JP2022009816A5 (https=) | ||
| JP2013517318A (ja) | Ｆｃ含有タンパク質を精製するためのクロマトグラフィー法 | |
| AU2017298984A1 (en) | Methods of purifying Fc-containing proteins | |
| JPWO2021212084A5 (https=) | ||
| JPWO2020088459A5 (https=) | ||
| JPWO2022072446A5 (https=) | ||
| JP2024500354A (ja) | ヘテロ二量体化のための直交変異 | |
| JPWO2021212081A5 (https=) | ||
| RU2023105687A (ru) | Варианты кошачьих антител | |
| JP2021523101A5 (https=) | ||
| JP7784039B2 (ja) | 多重特異性抗体及びその製造方法 | |
| RU2024136642A (ru) | Мутанты собачьих антител | |
| EP4717704A1 (en) | Novel protein a ligand that enables milder elution | |
| JPWO2022067233A5 (https=) | ||
| JPWO2020154540A5 (https=) | ||
| WO2021136256A1 (zh) | 一种得到高纯度异源抗体的方法 | |
| RU2025102187A (ru) | Мутанты бычьих антител | |
| EA041608B1 (ru) | Гетеродимерный полиспецифичный формат антител |