JPWO2021205144A5 - - Google Patents
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- Publication number
- JPWO2021205144A5 JPWO2021205144A5 JP2022561648A JP2022561648A JPWO2021205144A5 JP WO2021205144 A5 JPWO2021205144 A5 JP WO2021205144A5 JP 2022561648 A JP2022561648 A JP 2022561648A JP 2022561648 A JP2022561648 A JP 2022561648A JP WO2021205144 A5 JPWO2021205144 A5 JP WO2021205144A5
- Authority
- JP
- Japan
- Prior art keywords
- acceptable acid
- acid addition
- addition salt
- pindolol
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims description 45
- 239000002253 acid Substances 0.000 claims description 37
- 229960002508 pindolol Drugs 0.000 claims description 25
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 10
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 206010006895 Cachexia Diseases 0.000 claims description 5
- 208000010428 Muscle Weakness Diseases 0.000 claims description 5
- 206010028372 Muscular weakness Diseases 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 4
- 235000010233 benzoic acid Nutrition 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 206010002383 Angina Pectoris Diseases 0.000 claims description 3
- 208000019901 Anxiety disease Diseases 0.000 claims description 3
- 206010003658 Atrial Fibrillation Diseases 0.000 claims description 3
- 208000010412 Glaucoma Diseases 0.000 claims description 3
- 206010019280 Heart failures Diseases 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 208000010125 myocardial infarction Diseases 0.000 claims description 3
- 208000018360 neuromuscular disease Diseases 0.000 claims description 3
- 208000001076 sarcopenia Diseases 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000012453 solvate Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 description 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 5
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 3
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 2
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 description 1
- LNETULKMXZVUST-UHFFFAOYSA-N 1-naphthoic acid Chemical compound C1=CC=C2C(C(=O)O)=CC=CC2=C1 LNETULKMXZVUST-UHFFFAOYSA-N 0.000 description 1
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
- 229960000583 acetic acid Drugs 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 239000001361 adipic acid Substances 0.000 description 1
- 235000011037 adipic acid Nutrition 0.000 description 1
- 229960000250 adipic acid Drugs 0.000 description 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000006806 disease prevention Effects 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 229960002050 hydrofluoric acid Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 229940095574 propionic acid Drugs 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2005112.4A GB2593902B (en) | 2020-04-07 | 2020-04-07 | Salt of a pharmaceutical compound |
| GB2005112.4 | 2020-04-07 | ||
| PCT/GB2021/050799 WO2021205144A1 (en) | 2020-04-07 | 2021-03-31 | Organic acid addition salts of s-pindolol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023521985A JP2023521985A (ja) | 2023-05-26 |
| JPWO2021205144A5 true JPWO2021205144A5 (fi) | 2024-03-29 |
Family
ID=70768820
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561648A Pending JP2023521985A (ja) | 2020-04-07 | 2021-03-31 | Ｓ－ピンドロールの有機酸付加塩 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20230190706A1 (fi) |
| EP (2) | EP4132909B1 (fi) |
| JP (1) | JP2023521985A (fi) |
| KR (1) | KR20220164521A (fi) |
| CN (1) | CN115916751A (fi) |
| AU (1) | AU2021253747A1 (fi) |
| BR (1) | BR112022020198A2 (fi) |
| CA (1) | CA3173878A1 (fi) |
| DK (1) | DK4132909T3 (fi) |
| FI (1) | FI4132909T3 (fi) |
| GB (1) | GB2593902B (fi) |
| IL (1) | IL297045A (fi) |
| LT (1) | LT4132909T (fi) |
| MX (1) | MX2022012492A (fi) |
| PT (1) | PT4132909T (fi) |
| WO (1) | WO2021205144A1 (fi) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB202114564D0 (en) * | 2021-10-12 | 2021-11-24 | Actimed Therapeutics Ltd | Oral formulation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
| AT336176B (de) * | 1971-12-10 | 1977-04-25 | Sandoz Ag | Verfahren zur herstellung eines pharmazeutischen praparates |
| DE3544172A1 (de) * | 1985-12-13 | 1987-06-19 | Lentia Gmbh | Neue kristalline salze von aryloxy-propanolaminen, verfahren zu ihrer herstellung und ihre verwendung |
| JPH01287064A (ja) | 1988-05-13 | 1989-11-17 | Lion Corp | 光学活性アミノプロパノール誘導体の製造方法 |
| GB0624282D0 (en) * | 2006-12-05 | 2007-01-10 | Cavalla David | Treatment of cachexia |
| EP2877247A1 (en) * | 2012-07-25 | 2015-06-03 | Psioxus Therapeutics Limited | Use of s-pindolol for treating cachexia and sarcopenia |
| CA3203368A1 (en) * | 2016-02-26 | 2017-08-31 | Actimed Therapeutics Ltd | S-enantiomerically enriched compositions of beta blockers for treating muscle weakness |
-
2020
- 2020-04-07 GB GB2005112.4A patent/GB2593902B/en active Active
-
2021
- 2021-03-31 US US17/995,621 patent/US20230190706A1/en active Pending
- 2021-03-31 IL IL297045A patent/IL297045A/en unknown
- 2021-03-31 CA CA3173878A patent/CA3173878A1/en active Pending
- 2021-03-31 AU AU2021253747A patent/AU2021253747A1/en active Pending
- 2021-03-31 DK DK21717172.7T patent/DK4132909T3/da active
- 2021-03-31 WO PCT/GB2021/050799 patent/WO2021205144A1/en unknown
- 2021-03-31 EP EP21717172.7A patent/EP4132909B1/en active Active
- 2021-03-31 MX MX2022012492A patent/MX2022012492A/es unknown
- 2021-03-31 FI FIEP21717172.7T patent/FI4132909T3/fi active
- 2021-03-31 JP JP2022561648A patent/JP2023521985A/ja active Pending
- 2021-03-31 BR BR112022020198A patent/BR112022020198A2/pt unknown
- 2021-03-31 KR KR1020227037233A patent/KR20220164521A/ko unknown
- 2021-03-31 LT LTEPPCT/GB2021/050799T patent/LT4132909T/lt unknown
- 2021-03-31 EP EP24160044.4A patent/EP4385566A2/en active Pending
- 2021-03-31 PT PT217171727T patent/PT4132909T/pt unknown
- 2021-03-31 CN CN202180040441.2A patent/CN115916751A/zh active Pending
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