JPWO2021153047A5 - - Google Patents
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- JPWO2021153047A5 JPWO2021153047A5 JP2021574515A JP2021574515A JPWO2021153047A5 JP WO2021153047 A5 JPWO2021153047 A5 JP WO2021153047A5 JP 2021574515 A JP2021574515 A JP 2021574515A JP 2021574515 A JP2021574515 A JP 2021574515A JP WO2021153047 A5 JPWO2021153047 A5 JP WO2021153047A5
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- JP
- Japan
- Prior art keywords
- group
- nucleic acid
- formula
- solution
- hydroxyl group
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020012787 | 2020-01-29 | ||
| JP2020012787 | 2020-01-29 | ||
| PCT/JP2020/046572 WO2021153047A1 (ja) | 2020-01-29 | 2020-12-14 | 核酸オリゴマーの製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021153047A1 JPWO2021153047A1 (https=) | 2021-08-05 |
| JPWO2021153047A5 true JPWO2021153047A5 (https=) | 2023-11-28 |
| JP7777452B2 JP7777452B2 (ja) | 2025-11-28 |
Family
ID=77078498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021574515A Active JP7777452B2 (ja) | 2020-01-29 | 2020-12-14 | 核酸オリゴマーの製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20230312635A1 (https=) |
| EP (1) | EP4098655A4 (https=) |
| JP (1) | JP7777452B2 (https=) |
| KR (1) | KR20220133878A (https=) |
| CN (1) | CN115003682A (https=) |
| WO (1) | WO2021153047A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7667788B2 (ja) | 2020-01-29 | 2025-04-23 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| CN114685572B (zh) * | 2022-06-02 | 2022-08-30 | 上海百力格生物技术有限公司 | 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法 |
| CN115925774B (zh) * | 2022-12-22 | 2024-06-14 | 百力格生物科技(上海)股份有限公司 | 合成特异性分子标签的方法及其分子标签接头 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07112997A (ja) * | 1993-08-06 | 1995-05-02 | Takeda Chem Ind Ltd | オリゴヌクレオチド誘導体、その製造法、製造中間体および用途 |
| US6518017B1 (en) | 1997-10-02 | 2003-02-11 | Oasis Biosciences Incorporated | Combinatorial antisense library |
| US6077709A (en) | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| US6887990B1 (en) | 1999-02-05 | 2005-05-03 | Amersham Biosciences Corp | Method for deprotecting oligonucleotides |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| JP4709959B2 (ja) | 2001-06-14 | 2011-06-29 | 国立大学法人東京工業大学 | ヌクレオシドホスホロアミダイト化合物 |
| AU2005275801B2 (en) | 2004-08-26 | 2012-05-10 | Nippon Shinyaku Co., Ltd. | Phosphoramidite compound and method for producing oligo-RNA |
| ES2526295T5 (es) | 2006-10-18 | 2021-05-04 | Ionis Pharmaceuticals Inc | Compuestos antisentido |
| EP2933333B1 (en) | 2010-07-08 | 2018-02-21 | Bonac Corporation | Single-strand nucleic acid molecule for controlling gene expression |
| EP2639307B1 (en) | 2010-08-03 | 2015-03-04 | Bonac Corporation | Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton |
| MX370398B (es) * | 2011-08-25 | 2019-12-11 | Bonac Corp | Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico. |
| AU2013266968B2 (en) | 2012-05-25 | 2017-06-29 | Emmanuelle CHARPENTIER | Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription |
| WO2015006740A2 (en) | 2013-07-11 | 2015-01-15 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| CA2969619A1 (en) | 2014-12-03 | 2016-06-09 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
| EP3450439B8 (en) | 2016-04-26 | 2021-06-30 | Sumitomo Chemical Company, Limited | Method for producing monomer for single-stranded nucleic acid molecule |
| JPWO2018182008A1 (ja) | 2017-03-31 | 2020-02-06 | 株式会社ボナック | 遺伝子発現制御機能を有する環状型核酸分子 |
| BR112020005230A2 (pt) | 2017-09-19 | 2020-09-24 | Alnylam Pharmaceuticals, Inc. | composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr) |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| JP6817493B2 (ja) | 2018-03-30 | 2021-01-20 | 住友化学株式会社 | 一本鎖ｒｎａの製造方法 |
| KR102670605B1 (ko) * | 2018-04-24 | 2024-05-29 | 스미또모 가가꾸 가부시끼가이샤 | 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법 |
| US12139507B2 (en) | 2018-05-02 | 2024-11-12 | Natias Inc. | Segment for use in synthesis of oligonucleotide, method for producing the same, and method for synthesizing oligonucleotide using the same |
| JP7135532B2 (ja) | 2018-07-20 | 2022-09-13 | マツダ株式会社 | 電池状態推定装置、電池状態推定装置の製造方法、電池状態推定方法、および組電池システム |
| WO2020236618A1 (en) | 2019-05-17 | 2020-11-26 | Ionis Pharmaceuticals, Inc. | Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphate diester linkages |
| CN113993876B (zh) | 2019-06-11 | 2024-06-14 | 豪夫迈·罗氏有限公司 | 使用改进的氧化方案制备寡核苷酸的方法 |
| JP7640461B2 (ja) * | 2019-10-11 | 2025-03-05 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
| KR20230074205A (ko) * | 2020-09-24 | 2023-05-26 | 스미또모 가가꾸 가부시끼가이샤 | 핵산 올리고머의 제조 방법 |
-
2020
- 2020-12-14 EP EP20917061.2A patent/EP4098655A4/en active Pending
- 2020-12-14 WO PCT/JP2020/046572 patent/WO2021153047A1/ja not_active Ceased
- 2020-12-14 KR KR1020227024706A patent/KR20220133878A/ko active Pending
- 2020-12-14 CN CN202080095007.XA patent/CN115003682A/zh active Pending
- 2020-12-14 US US17/759,597 patent/US20230312635A1/en active Pending
- 2020-12-14 JP JP2021574515A patent/JP7777452B2/ja active Active
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