JP7777452B2 - 核酸オリゴマーの製造方法 - Google Patents

核酸オリゴマーの製造方法

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Publication number
JP7777452B2
JP7777452B2 JP2021574515A JP2021574515A JP7777452B2 JP 7777452 B2 JP7777452 B2 JP 7777452B2 JP 2021574515 A JP2021574515 A JP 2021574515A JP 2021574515 A JP2021574515 A JP 2021574515A JP 7777452 B2 JP7777452 B2 JP 7777452B2
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Japan
Prior art keywords
group
formula
nucleic acid
independently
iodine
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English (en)
Japanese (ja)
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JPWO2021153047A5 (https=
JPWO2021153047A1 (https=
Inventor
卓也 宮川
匡 西尾
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Saccharide Compounds (AREA)
JP2021574515A 2020-01-29 2020-12-14 核酸オリゴマーの製造方法 Active JP7777452B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020012787 2020-01-29
JP2020012787 2020-01-29
PCT/JP2020/046572 WO2021153047A1 (ja) 2020-01-29 2020-12-14 核酸オリゴマーの製造方法

Publications (3)

Publication Number Publication Date
JPWO2021153047A1 JPWO2021153047A1 (https=) 2021-08-05
JPWO2021153047A5 JPWO2021153047A5 (https=) 2023-11-28
JP7777452B2 true JP7777452B2 (ja) 2025-11-28

Family

ID=77078498

Family Applications (1)

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JP2021574515A Active JP7777452B2 (ja) 2020-01-29 2020-12-14 核酸オリゴマーの製造方法

Country Status (6)

Country Link
US (1) US20230312635A1 (https=)
EP (1) EP4098655A4 (https=)
JP (1) JP7777452B2 (https=)
KR (1) KR20220133878A (https=)
CN (1) CN115003682A (https=)
WO (1) WO2021153047A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7667788B2 (ja) 2020-01-29 2025-04-23 住友化学株式会社 核酸オリゴマーの製造方法
CN114685572B (zh) * 2022-06-02 2022-08-30 上海百力格生物技术有限公司 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法
CN115925774B (zh) * 2022-12-22 2024-06-14 百力格生物科技(上海)股份有限公司 合成特异性分子标签的方法及其分子标签接头

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JP2002371095A (ja) 2001-06-14 2002-12-26 Rikogaku Shinkokai ヌクレオシドホスホロアミダイト化合物
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
JP2016529230A (ja) 2013-07-11 2016-09-23 アルニラム ファーマスーティカルズ インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法
WO2019189591A1 (ja) 2018-03-30 2019-10-03 住友化学株式会社 一本鎖ｒｎａの製造方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
WO2019212061A1 (ja) 2018-05-02 2019-11-07 株式会社四国核酸化学 オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法

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JPH07112997A (ja) * 1993-08-06 1995-05-02 Takeda Chem Ind Ltd オリゴヌクレオチド誘導体、その製造法、製造中間体および用途
US6518017B1 (en) 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US6077709A (en) 1998-09-29 2000-06-20 Isis Pharmaceuticals Inc. Antisense modulation of Survivin expression
US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
EP2639307B1 (en) 2010-08-03 2015-03-04 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
CA2969619A1 (en) 2014-12-03 2016-06-09 Agilent Technologies, Inc. Guide rna with chemical modifications
EP3450439B8 (en) 2016-04-26 2021-06-30 Sumitomo Chemical Company, Limited Method for producing monomer for single-stranded nucleic acid molecule
JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP7135532B2 (ja) 2018-07-20 2022-09-13 マツダ株式会社 電池状態推定装置、電池状態推定装置の製造方法、電池状態推定方法、および組電池システム
WO2020236618A1 (en) 2019-05-17 2020-11-26 Ionis Pharmaceuticals, Inc. Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphate diester linkages
CN113993876B (zh) 2019-06-11 2024-06-14 豪夫迈·罗氏有限公司 使用改进的氧化方案制备寡核苷酸的方法
JP7640461B2 (ja) * 2019-10-11 2025-03-05 住友化学株式会社 核酸オリゴマーの製造方法
KR20230074205A (ko) * 2020-09-24 2023-05-26 스미또모 가가꾸 가부시끼가이샤 핵산 올리고머의 제조 방법

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* Cited by examiner, † Cited by third party
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JP2002371095A (ja) 2001-06-14 2002-12-26 Rikogaku Shinkokai ヌクレオシドホスホロアミダイト化合物
WO2013027843A1 (ja) 2011-08-25 2013-02-28 株式会社ボナック 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法
JP2016529230A (ja) 2013-07-11 2016-09-23 アルニラム ファーマスーティカルズ インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オリゴヌクレオチド−リガンドコンジュゲートおよびそれらの調製方法
WO2019189591A1 (ja) 2018-03-30 2019-10-03 住友化学株式会社 一本鎖ｒｎａの製造方法
WO2019208571A1 (ja) 2018-04-24 2019-10-31 住友化学株式会社 アミダイト化合物及び該化合物を用いたポリヌクレオチドの製造方法
WO2019212061A1 (ja) 2018-05-02 2019-11-07 株式会社四国核酸化学 オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法

Non-Patent Citations (1)

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和光純薬時報，2018年，Vol.86, No.4，pp.12-13，ISSN 1347-4804

Also Published As

Publication number Publication date
EP4098655A4 (en) 2024-02-28
JPWO2021153047A1 (https=) 2021-08-05
KR20220133878A (ko) 2022-10-05
CN115003682A (zh) 2022-09-02
EP4098655A1 (en) 2022-12-07
WO2021153047A1 (ja) 2021-08-05
US20230312635A1 (en) 2023-10-05

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