CN115003682A - 核酸寡聚物的制造方法 - Google Patents

核酸寡聚物的制造方法 Download PDF

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Publication number
CN115003682A
CN115003682A CN202080095007.XA CN202080095007A CN115003682A CN 115003682 A CN115003682 A CN 115003682A CN 202080095007 A CN202080095007 A CN 202080095007A CN 115003682 A CN115003682 A CN 115003682A
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China
Prior art keywords
group
formula
nucleic acid
production method
iodine
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Pending
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CN202080095007.XA
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English (en)
Chinese (zh)
Inventor
宫川卓也
西尾匡
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Sumitomo Chemical Co Ltd
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Sumitomo Chemical Co Ltd
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Publication of CN115003682A publication Critical patent/CN115003682A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon or a metal, e.g. chelates or vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Saccharide Compounds (AREA)
CN202080095007.XA 2020-01-29 2020-12-14 核酸寡聚物的制造方法 Pending CN115003682A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020-012787 2020-01-29
JP2020012787 2020-01-29
PCT/JP2020/046572 WO2021153047A1 (ja) 2020-01-29 2020-12-14 核酸オリゴマーの製造方法

Publications (1)

Publication Number Publication Date
CN115003682A true CN115003682A (zh) 2022-09-02

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Family Applications (1)

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CN202080095007.XA Pending CN115003682A (zh) 2020-01-29 2020-12-14 核酸寡聚物的制造方法

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US (1) US20230312635A1 (https=)
EP (1) EP4098655A4 (https=)
JP (1) JP7777452B2 (https=)
KR (1) KR20220133878A (https=)
CN (1) CN115003682A (https=)
WO (1) WO2021153047A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115003680A (zh) * 2020-01-29 2022-09-02 住友化学株式会社 制备核酸寡聚物的方法

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* Cited by examiner, † Cited by third party
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CN114685572B (zh) * 2022-06-02 2022-08-30 上海百力格生物技术有限公司 用于mgb核酸探针合成的氧化剂组合物及探针的合成方法
CN115925774B (zh) * 2022-12-22 2024-06-14 百力格生物科技(上海)股份有限公司 合成特异性分子标签的方法及其分子标签接头

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JP2002371095A (ja) * 2001-06-14 2002-12-26 Rikogaku Shinkokai ヌクレオシドホスホロアミダイト化合物
CN103906758A (zh) * 2011-08-25 2014-07-02 株式会社博纳克 配糖体化合物、硫醚的制造方法、醚、醚的制造方法、配糖体化合物的制造方法及核酸的制造方法
CN114502566A (zh) * 2019-10-11 2022-05-13 住友化学株式会社 核酸寡聚物的制造方法
CN116209668A (zh) * 2020-09-24 2023-06-02 住友化学株式会社 核酸寡聚物的制造方法

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US6518017B1 (en) 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
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US6887990B1 (en) 1999-02-05 2005-05-03 Amersham Biosciences Corp Method for deprotecting oligonucleotides
US6261840B1 (en) 2000-01-18 2001-07-17 Isis Pharmaceuticals, Inc. Antisense modulation of PTP1B expression
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
ES2526295T5 (es) 2006-10-18 2021-05-04 Ionis Pharmaceuticals Inc Compuestos antisentido
EP2933333B1 (en) 2010-07-08 2018-02-21 Bonac Corporation Single-strand nucleic acid molecule for controlling gene expression
EP2639307B1 (en) 2010-08-03 2015-03-04 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
AU2013266968B2 (en) 2012-05-25 2017-06-29 Emmanuelle CHARPENTIER Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
WO2015006740A2 (en) 2013-07-11 2015-01-15 Alnylam Pharmaceuticals, Inc. Oligonucleotide-ligand conjugates and process for their preparation
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JPWO2018182008A1 (ja) 2017-03-31 2020-02-06 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
BR112020005230A2 (pt) 2017-09-19 2020-09-24 Alnylam Pharmaceuticals, Inc. composições e métodos para o tratamento da amiloidose mediada por transtiretina (ttr)
US20210188895A1 (en) 2017-10-13 2021-06-24 Bonac Corporation Single-stranded nucleic acid molecule, and production method therefor
JP6817493B2 (ja) 2018-03-30 2021-01-20 住友化学株式会社 一本鎖ｒｎａの製造方法
KR102670605B1 (ko) * 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법
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JP7135532B2 (ja) 2018-07-20 2022-09-13 マツダ株式会社 電池状態推定装置、電池状態推定装置の製造方法、電池状態推定方法、および組電池システム
WO2020236618A1 (en) 2019-05-17 2020-11-26 Ionis Pharmaceuticals, Inc. Synthesis of oligomeric compounds comprising phosphorothioate diester and phosphate diester linkages
CN113993876B (zh) 2019-06-11 2024-06-14 豪夫迈·罗氏有限公司 使用改进的氧化方案制备寡核苷酸的方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002371095A (ja) * 2001-06-14 2002-12-26 Rikogaku Shinkokai ヌクレオシドホスホロアミダイト化合物
CN103906758A (zh) * 2011-08-25 2014-07-02 株式会社博纳克 配糖体化合物、硫醚的制造方法、醚、醚的制造方法、配糖体化合物的制造方法及核酸的制造方法
CN114502566A (zh) * 2019-10-11 2022-05-13 住友化学株式会社 核酸寡聚物的制造方法
CN116209668A (zh) * 2020-09-24 2023-06-02 住友化学株式会社 核酸寡聚物的制造方法

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115003680A (zh) * 2020-01-29 2022-09-02 住友化学株式会社 制备核酸寡聚物的方法
CN115003680B (zh) * 2020-01-29 2025-01-28 住友化学株式会社 制备核酸寡聚物的方法
US12391716B2 (en) 2020-01-29 2025-08-19 Sumitomo Chemical Company, Limited Process of preparing nucleic acid oligomer

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JP7777452B2 (ja) 2025-11-28
EP4098655A4 (en) 2024-02-28
JPWO2021153047A1 (https=) 2021-08-05
KR20220133878A (ko) 2022-10-05
EP4098655A1 (en) 2022-12-07
WO2021153047A1 (ja) 2021-08-05
US20230312635A1 (en) 2023-10-05

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