JPWO2021108809A5 - - Google Patents
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- Publication number
- JPWO2021108809A5 JPWO2021108809A5 JP2022530164A JP2022530164A JPWO2021108809A5 JP WO2021108809 A5 JPWO2021108809 A5 JP WO2021108809A5 JP 2022530164 A JP2022530164 A JP 2022530164A JP 2022530164 A JP2022530164 A JP 2022530164A JP WO2021108809 A5 JPWO2021108809 A5 JP WO2021108809A5
- Authority
- JP
- Japan
- Prior art keywords
- capsid protein
- pharmaceutical composition
- vector
- aav
- apoe2
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000702423 Adeno-associated virus - 2 Species 0.000 claims description 4
- 241001164825 Adeno-associated virus - 8 Species 0.000 claims description 4
- 241001634120 Adeno-associated virus - 5 Species 0.000 claims description 3
- 241001164823 Adeno-associated virus - 7 Species 0.000 claims description 2
- 241000702421 Dependoparvovirus Species 0.000 claims description 2
- 108090000565 Capsid Proteins Proteins 0.000 claims 10
- 102100023321 Ceruloplasmin Human genes 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 239000013598 vector Substances 0.000 claims 6
- 102100021244 Integral membrane protein GPR180 Human genes 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 241001655883 Adeno-associated virus - 1 Species 0.000 claims 1
- 241000580270 Adeno-associated virus - 4 Species 0.000 claims 1
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000007592 Apolipoproteins Human genes 0.000 claims 1
- 108010071619 Apolipoproteins Proteins 0.000 claims 1
- 101000834253 Gallus gallus Actin, cytoplasmic 1 Proteins 0.000 claims 1
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000007523 nucleic acids Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025124433A JP2025163078A (ja) | 2019-11-25 | 2025-07-25 | Ａｐｏｅ遺伝子療法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962939999P | 2019-11-25 | 2019-11-25 | |
| US62/939,999 | 2019-11-25 | ||
| PCT/US2020/070822 WO2021108809A1 (en) | 2019-11-25 | 2020-11-25 | Apoe gene therapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025124433A Division JP2025163078A (ja) | 2019-11-25 | 2025-07-25 | Ａｐｏｅ遺伝子療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023502515A JP2023502515A (ja) | 2023-01-24 |
| JPWO2021108809A5 true JPWO2021108809A5 (https=) | 2023-11-28 |
| JP2023502515A5 JP2023502515A5 (https=) | 2023-11-28 |
Family
ID=73857283
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022530164A Pending JP2023502515A (ja) | 2019-11-25 | 2020-11-25 | Ａｐｏｅ遺伝子療法 |
| JP2025124433A Pending JP2025163078A (ja) | 2019-11-25 | 2025-07-25 | Ａｐｏｅ遺伝子療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025124433A Pending JP2025163078A (ja) | 2019-11-25 | 2025-07-25 | Ａｐｏｅ遺伝子療法 |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP4065600A1 (https=) |
| JP (2) | JP2023502515A (https=) |
| KR (1) | KR20220107243A (https=) |
| CN (1) | CN114829390A (https=) |
| AU (1) | AU2020391518B2 (https=) |
| BR (1) | BR112022010065A2 (https=) |
| CA (1) | CA3162761A1 (https=) |
| IL (1) | IL293116A (https=) |
| MX (1) | MX2022006364A (https=) |
| NZ (1) | NZ789753A (https=) |
| WO (1) | WO2021108809A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| AU2020214796A1 (en) | 2019-01-30 | 2021-07-29 | Truebinding, Inc. | Anti-Gal3 antibodies and uses thereof |
| WO2021242776A2 (en) | 2020-05-26 | 2021-12-02 | Truebinding, Inc. | Methods of treating inflammatory diseases by blocking galectin-3 |
| KR20230112672A (ko) * | 2020-11-25 | 2023-07-27 | 프리베일 테라퓨틱스, 인크. | 신경변성 질환을 위한 유전자 요법 |
| EP4508213A1 (en) * | 2022-04-12 | 2025-02-19 | uniQure biopharma B.V. | Nucleic acid regulation of apoe |
| WO2023198702A1 (en) * | 2022-04-12 | 2023-10-19 | Uniqure Biopharma B.V. | Nucleic acid regulation of c9orf72 |
| EP4551711A1 (en) * | 2022-07-08 | 2025-05-14 | Cornell University | Methods and pharmaceutical compositions for the treatment and the prevention of alzheimers disease |
| WO2025213111A2 (en) * | 2024-04-05 | 2025-10-09 | Cornell University | Aav expression of mirna to suppress human apoe mrna |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4863457A (en) | 1986-11-24 | 1989-09-05 | Lee David A | Drug delivery device |
| US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
| AU4198793A (en) | 1992-07-24 | 1994-01-27 | Takeda Chemical Industries Ltd. | Microparticle preparation and production thereof |
| FR2695563B1 (fr) | 1992-09-11 | 1994-12-02 | Pasteur Institut | Microparticules portant des antigènes et leur utilisation pour l'induction de réponses humorales ou cellulaires. |
| US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
| ATE163230T1 (de) | 1993-03-09 | 1998-02-15 | Epic Therapeutics Inc | Makromolekulare mikropartikel und verfahren zu ihrer herstellung |
| US5603960A (en) | 1993-05-25 | 1997-02-18 | O'hagan; Derek T. | Preparation of microparticles and method of immunization |
| US6913767B1 (en) | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
| US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
| CA2267930A1 (en) | 1996-10-09 | 1998-04-16 | Nobuyuki Takechi | A method for producing a microparticle |
| US6210707B1 (en) | 1996-11-12 | 2001-04-03 | The Regents Of The University Of California | Methods of forming protein-linked lipidic microparticles, and compositions thereof |
| US6884435B1 (en) | 1997-01-30 | 2005-04-26 | Chiron Corporation | Microparticles with adsorbent surfaces, methods of making same, and uses thereof |
| US6406719B1 (en) | 1998-05-13 | 2002-06-18 | Microbiological Research Authority | Encapsulation of bioactive agents |
| GB9810236D0 (en) | 1998-05-13 | 1998-07-08 | Microbiological Res Authority | Improvements relating to encapsulation of bioactive agents |
| US6264987B1 (en) | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
| WO2007041190A2 (en) | 2005-09-30 | 2007-04-12 | The University Of Iowa Research Foundation | Polymer-based delivery system for immunotherapy of cancer |
| US9572894B2 (en) | 2010-10-18 | 2017-02-21 | The University Of Iowa Research Foundation | Biodegradable particulate formulations |
| EP2673635A4 (en) | 2011-02-07 | 2015-08-12 | Neotope Biosciences Ltd | IMMUNOTHERAPY THROUGH APOE |
| WO2012115806A1 (en) | 2011-02-24 | 2012-08-30 | University Of Iowa Research Foundation | New biodegradable polymers with sulfenamide bonds for drug delivery applications |
| CN106890315B (zh) * | 2017-03-16 | 2019-09-06 | 北京热休生物技术有限公司 | Apo-e蛋白及其多肽在治疗与预防癌症中的应用 |
| JP7221275B2 (ja) * | 2017-08-03 | 2023-02-13 | ボイジャー セラピューティクス インコーポレイテッド | Ａａｖを送達するための組成物および方法 |
| CN109776665B (zh) * | 2019-02-02 | 2021-02-05 | 首都医科大学宣武医院 | 阿尔茨海默病新突变、其稳转细胞模型及医药用途 |
| CA3141988A1 (en) * | 2019-05-28 | 2020-12-03 | The General Hospital Corporation | Apoe antibodies, fusion proteins and uses thereof |
-
2020
- 2020-11-25 EP EP20828741.7A patent/EP4065600A1/en active Pending
- 2020-11-25 JP JP2022530164A patent/JP2023502515A/ja active Pending
- 2020-11-25 NZ NZ789753A patent/NZ789753A/en unknown
- 2020-11-25 WO PCT/US2020/070822 patent/WO2021108809A1/en not_active Ceased
- 2020-11-25 BR BR112022010065A patent/BR112022010065A2/pt unknown
- 2020-11-25 CN CN202080081724.7A patent/CN114829390A/zh active Pending
- 2020-11-25 IL IL293116A patent/IL293116A/en unknown
- 2020-11-25 CA CA3162761A patent/CA3162761A1/en active Pending
- 2020-11-25 MX MX2022006364A patent/MX2022006364A/es unknown
- 2020-11-25 AU AU2020391518A patent/AU2020391518B2/en active Active
- 2020-11-25 KR KR1020227021579A patent/KR20220107243A/ko active Pending
-
2025
- 2025-07-25 JP JP2025124433A patent/JP2025163078A/ja active Pending
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