JPWO2021095828A5 - - Google Patents
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- Publication number
- JPWO2021095828A5 JPWO2021095828A5 JP2021556161A JP2021556161A JPWO2021095828A5 JP WO2021095828 A5 JPWO2021095828 A5 JP WO2021095828A5 JP 2021556161 A JP2021556161 A JP 2021556161A JP 2021556161 A JP2021556161 A JP 2021556161A JP WO2021095828 A5 JPWO2021095828 A5 JP WO2021095828A5
- Authority
- JP
- Japan
- Prior art keywords
- acetylglucosaminated
- protein
- linked
- substance
- substance according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 claims 7
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical group CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 1
- JAHNSTQSQJOJLO-UHFFFAOYSA-N 2-(3-fluorophenyl)-1h-imidazole Chemical compound FC1=CC=CC(C=2NC=CN=2)=C1 JAHNSTQSQJOJLO-UHFFFAOYSA-N 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- SBWOBTUYQXLKSS-UHFFFAOYSA-N 3-(2-methylprop-2-enoyloxy)propanoic acid Chemical compound CC(=C)C(=O)OCCC(O)=O SBWOBTUYQXLKSS-UHFFFAOYSA-N 0.000 claims 1
- CYUZOYPRAQASLN-UHFFFAOYSA-N 3-prop-2-enoyloxypropanoic acid Chemical compound OC(=O)CCOC(=O)C=C CYUZOYPRAQASLN-UHFFFAOYSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- LDHQCZJRKDOVOX-NSCUHMNNSA-N crotonic acid Chemical compound C\C=C\C(O)=O LDHQCZJRKDOVOX-NSCUHMNNSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 239000011976 maleic acid Substances 0.000 claims 1
- LVHBHZANLOWSRM-UHFFFAOYSA-N methylenebutanedioic acid Natural products OC(=O)CC(=C)C(O)=O LVHBHZANLOWSRM-UHFFFAOYSA-N 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
- LDHQCZJRKDOVOX-UHFFFAOYSA-N trans-crotonic acid Natural products CC=CC(O)=O LDHQCZJRKDOVOX-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019206265 | 2019-11-14 | ||
| JP2019206265 | 2019-11-14 | ||
| PCT/JP2020/042362 WO2021095828A1 (ja) | 2019-11-14 | 2020-11-13 | Ｏ結合型ｎ－アセチルグルコサミン化タンパク質様物質及びこれを含有する線維症治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021095828A1 JPWO2021095828A1 (https=) | 2021-05-20 |
| JPWO2021095828A5 true JPWO2021095828A5 (https=) | 2023-10-31 |
| JP7637948B2 JP7637948B2 (ja) | 2025-03-03 |
Family
ID=75912746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021556161A Active JP7637948B2 (ja) | 2019-11-14 | 2020-11-13 | Ｏ結合型ｎ－アセチルグルコサミン化タンパク質様物質及びこれを含有する線維症治療薬 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20220389047A1 (https=) |
| EP (1) | EP4059567A4 (https=) |
| JP (1) | JP7637948B2 (https=) |
| KR (1) | KR102949437B1 (https=) |
| CN (1) | CN114945609A (https=) |
| CA (1) | CA3158028A1 (https=) |
| WO (1) | WO2021095828A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20250197865A1 (en) * | 2022-03-03 | 2025-06-19 | Kyushu University, National University Corporation | Pharmaceutical composition for treatment or prevention of fibrotic disease |
| EP4603100A1 (en) * | 2022-10-14 | 2025-08-20 | Kyushu University, National University Corporation | Antifibrotic agent, pharmaceutical composition for treating fibrosis, and method for inactivating myofibroblast |
| WO2025216313A1 (ja) * | 2024-04-12 | 2025-10-16 | 国立大学法人九州大学 | 共重合体、抗線維化剤、線維症治療用医薬組成物及び筋線維芽細胞を不活性化する方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7244830B2 (en) * | 2001-01-12 | 2007-07-17 | Emory University | Glycopolymers and free radical polymerization methods |
| JP2004043782A (ja) * | 2002-05-09 | 2004-02-12 | Toyobo Co Ltd | オリゴ糖合成用水溶性高分子プライマー |
| WO2004099271A1 (ja) * | 2003-05-08 | 2004-11-18 | Toyo Boseki Kabushiki Kaisha | 糖鎖含有水溶性ポリマー化合物 |
| JP2007518830A (ja) * | 2003-12-31 | 2007-07-12 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | Ｎ−セチルグルコサミンを含有するオリゴマー |
| JP2006276238A (ja) * | 2005-03-28 | 2006-10-12 | Fuji Photo Film Co Ltd | 光重合性組成物及び平版印刷版原版 |
| JP5044777B2 (ja) * | 2006-05-09 | 2012-10-10 | 国立大学法人 東京医科歯科大学 | 細胞固定化基材被覆膜用材料 |
| JP2011190257A (ja) | 2010-02-22 | 2011-09-29 | Oita Univ | 組織線維化疾患の予防または治療剤 |
| WO2012171035A1 (en) | 2011-06-10 | 2012-12-13 | University Of Washington Through Its Center For Commercialization | Carbohydrate-based compositions and methods for targeted drug delivery |
| JP7109040B2 (ja) | 2016-07-25 | 2022-07-29 | 国立大学法人金沢大学 | 線維化抑制剤 |
| JP2019206265A (ja) | 2018-05-29 | 2019-12-05 | 株式会社デンソー | 車両用空調装置 |
| JP7341031B2 (ja) * | 2018-10-31 | 2023-09-08 | ソマール株式会社 | 間葉系幹細胞の分離・選別方法、培養方法及びそれに用いる選別材料 |
-
2020
- 2020-11-13 CA CA3158028A patent/CA3158028A1/en active Pending
- 2020-11-13 US US17/775,864 patent/US20220389047A1/en active Pending
- 2020-11-13 WO PCT/JP2020/042362 patent/WO2021095828A1/ja not_active Ceased
- 2020-11-13 JP JP2021556161A patent/JP7637948B2/ja active Active
- 2020-11-13 KR KR1020227019780A patent/KR102949437B1/ko active Active
- 2020-11-13 CN CN202080078767.XA patent/CN114945609A/zh active Pending
- 2020-11-13 EP EP20888113.6A patent/EP4059567A4/en active Pending
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