JPWO2021067326A5 - - Google Patents
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- Publication number
- JPWO2021067326A5 JPWO2021067326A5 JP2022520195A JP2022520195A JPWO2021067326A5 JP WO2021067326 A5 JPWO2021067326 A5 JP WO2021067326A5 JP 2022520195 A JP2022520195 A JP 2022520195A JP 2022520195 A JP2022520195 A JP 2022520195A JP WO2021067326 A5 JPWO2021067326 A5 JP WO2021067326A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropyl
- pyrrolo
- triazolo
- pyridin
- thiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 dioxothiomorpholinyl Chemical group 0.000 claims 96
- 125000000217 alkyl group Chemical group 0.000 claims 29
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 25
- 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims 22
- 125000003566 oxetanyl group Chemical group 0.000 claims 18
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 13
- 125000002757 morpholinyl group Chemical group 0.000 claims 12
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 12
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 11
- 150000001204 N-oxides Chemical class 0.000 claims 11
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 11
- 125000002393 azetidinyl group Chemical group 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 8
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 8
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 5
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 5
- 125000005961 oxazepanyl group Chemical group 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000004193 piperazinyl group Chemical group 0.000 claims 5
- 125000003386 piperidinyl group Chemical group 0.000 claims 5
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 4
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- OJEOJUQOECNDND-UHFFFAOYSA-N oxetan-3-amine Chemical compound NC1COC1 OJEOJUQOECNDND-UHFFFAOYSA-N 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 3
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- CKJNUZNMWOVDFN-UHFFFAOYSA-N methanone Chemical compound O=[CH-] CKJNUZNMWOVDFN-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- MHCVCKDNQYMGEX-UHFFFAOYSA-N 1,1'-biphenyl;phenoxybenzene Chemical group C1=CC=CC=C1C1=CC=CC=C1.C=1C=CC=CC=1OC1=CC=CC=C1 MHCVCKDNQYMGEX-UHFFFAOYSA-N 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
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- FODPLOACOFGOOB-UHFFFAOYSA-N C(C(C)C)NCC(=O)NC1CCC(CC1)C=1SC2=C(N=1)C(=C(N2)C=1C=C(C=2N(C=1)N=CN=2)OC)C(C)C Chemical compound C(C(C)C)NCC(=O)NC1CCC(CC1)C=1SC2=C(N=1)C(=C(N2)C=1C=C(C=2N(C=1)N=CN=2)OC)C(C)C FODPLOACOFGOOB-UHFFFAOYSA-N 0.000 claims 2
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| US10071079B2 (en) | 2016-06-29 | 2018-09-11 | Bristol-Myers Squibb Company | [1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds |
| BR112019001270A2 (pt) | 2016-07-30 | 2019-04-30 | Bristol-Myers Squibb Company | compostos indol substituídos com dimetoxifenila como inibidores de tlr7, tlr8 ou tlr9 |
| JP7028861B2 (ja) | 2016-09-09 | 2022-03-02 | ブリストル－マイヤーズ スクイブ カンパニー | ピリジル置換のインドール化合物 |
| EA202091484A1 (ru) | 2017-12-18 | 2021-03-25 | Бристол-Маерс Сквибб Компани | 4-азаиндольные соединения |
| KR102730859B1 (ko) * | 2017-12-20 | 2024-11-15 | 브리스톨-마이어스 스큅 컴퍼니 | 아릴 및 헤테로아릴 치환된 인돌 화합물 |
| CN120699039A (zh) * | 2019-11-04 | 2025-09-26 | 锐新医药公司 | Ras抑制剂 |
| MX2022005359A (es) * | 2019-11-04 | 2022-06-02 | Revolution Medicines Inc | Inhibidores de ras. |
| MX2023002248A (es) * | 2020-09-03 | 2023-05-16 | Revolution Medicines Inc | Uso de inhibidores de sos1 para tratar neoplasias malignas con mutaciones de shp2. |
| MX2023003060A (es) * | 2020-09-15 | 2023-04-05 | Revolution Medicines Inc | Derivados indolicos como inhibidores de ras en el tratamiento del cancer. |
-
2020
- 2020-09-30 EP EP20792833.4A patent/EP4041730A1/en active Pending
- 2020-09-30 JP JP2022520195A patent/JP7629007B2/ja active Active
- 2020-09-30 KR KR1020227014605A patent/KR20220075381A/ko active Pending
- 2020-09-30 WO PCT/US2020/053358 patent/WO2021067326A1/en not_active Ceased
- 2020-09-30 US US17/766,198 patent/US12448395B2/en active Active
- 2020-09-30 CN CN202080081684.6A patent/CN114761404B/zh active Active
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