JPWO2021066136A5 - - Google Patents
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- Publication number
- JPWO2021066136A5 JPWO2021066136A5 JP2021551476A JP2021551476A JPWO2021066136A5 JP WO2021066136 A5 JPWO2021066136 A5 JP WO2021066136A5 JP 2021551476 A JP2021551476 A JP 2021551476A JP 2021551476 A JP2021551476 A JP 2021551476A JP WO2021066136 A5 JPWO2021066136 A5 JP WO2021066136A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor antagonist
- prostaglandin synthesis
- crth2 receptor
- compound selected
- synthesis inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000009389 Prostaglandin D receptors Human genes 0.000 claims 5
- 108050000258 Prostaglandin D receptors Proteins 0.000 claims 5
- 230000015572 biosynthetic process Effects 0.000 claims 5
- 239000003112 inhibitor Substances 0.000 claims 5
- 150000003180 prostaglandins Chemical class 0.000 claims 5
- 239000002464 receptor antagonist Substances 0.000 claims 5
- 229940044551 receptor antagonist Drugs 0.000 claims 5
- 238000003786 synthesis reaction Methods 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 claims 4
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 claims 2
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 claims 2
- LDXDSHIEDAPSSA-OAHLLOKOSA-N Ramatroban Chemical compound N([C@@H]1CCC=2N(C3=CC=CC=C3C=2C1)CCC(=O)O)S(=O)(=O)C1=CC=C(F)C=C1 LDXDSHIEDAPSSA-OAHLLOKOSA-N 0.000 claims 2
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 2
- 229960001259 diclofenac Drugs 0.000 claims 2
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229960001680 ibuprofen Drugs 0.000 claims 2
- 229960000905 indomethacin Drugs 0.000 claims 2
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 claims 2
- 229960000991 ketoprofen Drugs 0.000 claims 2
- 229960002373 loxoprofen Drugs 0.000 claims 2
- BAZQYVYVKYOAGO-UHFFFAOYSA-M loxoprofen sodium hydrate Chemical compound O.O.[Na+].C1=CC(C(C([O-])=O)C)=CC=C1CC1C(=O)CCC1 BAZQYVYVKYOAGO-UHFFFAOYSA-M 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- NLSSUSRERAMBTA-UHFFFAOYSA-N n-[4-[4-(morpholine-4-carbonyl)piperidin-1-yl]phenyl]-2-phenoxypyrimidine-5-carboxamide Chemical compound C=1N=C(OC=2C=CC=CC=2)N=CC=1C(=O)NC(C=C1)=CC=C1N(CC1)CCC1C(=O)N1CCOCC1 NLSSUSRERAMBTA-UHFFFAOYSA-N 0.000 claims 2
- 229960002009 naproxen Drugs 0.000 claims 2
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229950004496 ramatroban Drugs 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019182859 | 2019-10-03 | ||
| JP2019182859 | 2019-10-03 | ||
| PCT/JP2020/037520 WO2021066136A1 (ja) | 2019-10-03 | 2020-10-02 | 筋ジストロフィー治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2021066136A1 JPWO2021066136A1 (https=) | 2021-04-08 |
| JPWO2021066136A5 true JPWO2021066136A5 (https=) | 2023-10-10 |
| JP7658909B2 JP7658909B2 (ja) | 2025-04-08 |
Family
ID=75338144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021551476A Active JP7658909B2 (ja) | 2019-10-03 | 2020-10-02 | 筋ジストロフィー治療薬 |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP7658909B2 (https=) |
| WO (1) | WO2021066136A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025028968A1 (ko) * | 2023-07-28 | 2025-02-06 | 고려대학교 산학협력단 | 잘토프로펜을 유효성분으로 포함하는 근이영양증 예방 또는 치료용 약학적 조성물 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4550394B2 (ja) * | 2003-10-14 | 2010-09-22 | 財団法人大阪バイオサイエンス研究所 | 筋変性疾患の治療用医薬組成物およびそのスクリーニング方法 |
| US20090088400A1 (en) * | 2007-09-11 | 2009-04-02 | Puymirat Jack | Prostaglandin e2 modulation and uses thereof |
| WO2017104728A1 (ja) * | 2015-12-16 | 2017-06-22 | 国立大学法人東京大学 | 食物アレルギー治療薬 |
-
2020
- 2020-10-02 WO PCT/JP2020/037520 patent/WO2021066136A1/ja not_active Ceased
- 2020-10-02 JP JP2021551476A patent/JP7658909B2/ja active Active
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