JPWO2021021986A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2021021986A5 JPWO2021021986A5 JP2022506169A JP2022506169A JPWO2021021986A5 JP WO2021021986 A5 JPWO2021021986 A5 JP WO2021021986A5 JP 2022506169 A JP2022506169 A JP 2022506169A JP 2022506169 A JP2022506169 A JP 2022506169A JP WO2021021986 A5 JPWO2021021986 A5 JP WO2021021986A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- imidazol
- alkyl
- pyrimidine
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962880923P | 2019-07-31 | 2019-07-31 | |
| US62/880,923 | 2019-07-31 | ||
| US201962951604P | 2019-12-20 | 2019-12-20 | |
| US62/951,604 | 2019-12-20 | ||
| US202063034750P | 2020-06-04 | 2020-06-04 | |
| US63/034,750 | 2020-06-04 | ||
| PCT/US2020/044156 WO2021021986A1 (en) | 2019-07-31 | 2020-07-30 | Heterobicyclic amides as inhibitors of cd38 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022542396A JP2022542396A (ja) | 2022-10-03 |
| JPWO2021021986A5 true JPWO2021021986A5 (ru) | 2023-08-07 |
Family
ID=72139677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506169A Pending JP2022542396A (ja) | 2019-07-31 | 2020-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11535621B2 (ru) |
| EP (1) | EP4003980A1 (ru) |
| JP (1) | JP2022542396A (ru) |
| KR (1) | KR20220061958A (ru) |
| CN (1) | CN114423753A (ru) |
| AU (1) | AU2020321956A1 (ru) |
| BR (1) | BR112022001291A2 (ru) |
| CA (1) | CA3147902A1 (ru) |
| IL (1) | IL289878A (ru) |
| MX (1) | MX2022001019A (ru) |
| TW (1) | TW202120496A (ru) |
| WO (1) | WO2021021986A1 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11535621B2 (en) | 2019-07-31 | 2022-12-27 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of CD38 |
| WO2022165114A1 (en) | 2021-01-29 | 2022-08-04 | Ribon Therapeutics, Inc. | Quinolines and azaquinolines as inhibitors of cd38 |
| AR126423A1 (es) * | 2021-07-12 | 2023-10-11 | Cytokinetics Inc | Moduladores de cd38 y métodos de uso de los mismos |
| WO2023084206A1 (en) | 2021-11-09 | 2023-05-19 | Cerevance Ltd | N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as cd38 inhibitors |
| CN114306366B (zh) * | 2021-11-30 | 2023-01-06 | 合肥康诺生物制药有限公司 | 含nad和cd38抑制剂的药物组合物及其用途 |
| WO2023098699A1 (en) * | 2021-12-01 | 2023-06-08 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| GB202207721D0 (en) * | 2022-05-25 | 2022-07-06 | Cerevance Ltd | Novel Compounds |
| KR20240020201A (ko) * | 2022-08-05 | 2024-02-14 | 주식회사 넥스트젠바이오사이언스 | 저산소증 유도 인자 1(hif-1) 억제제 또는 혈관내피성장인자(vegf)억제제 로서의 신규 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007309468B2 (en) * | 2006-10-19 | 2012-05-17 | Signal Pharmaceuticals, Llc | Heteroaryl compounds, compositions thereof, and use thereof as protein kinase inhibitors |
| EP2646020B1 (en) * | 2010-12-01 | 2016-09-21 | Glaxosmithkline LLC | Indoles |
| EP3466423B1 (en) * | 2011-10-19 | 2021-07-28 | Signal Pharmaceuticals, LLC | Treatment of cancer with tor kinase inhibitors |
| CA2854447A1 (en) * | 2011-11-04 | 2013-05-10 | Glaxosmithkline Intellectual Property (No.2) Limited | Method of treatment |
| MX358303B (es) * | 2012-02-24 | 2018-08-14 | Signal Pharm Llc | Uso de 7-(6-(2-hidroxipropan-2il) piridin-3-il)-1-((1r,4r)4-metoxi ciclohexil)-3, 4-dihidropirazin-[2,3-b] pirazin-2(1h)-ona o una sal, estereoisómero o tautómero aceptable farmaceuticamente del mismo, en combinación con una cantidad efectiva de erlotinib o azacitidina para preparar un composición farmacéutica en el tratamiento de cáncer de pulmón de cédula no pequeña, avanzado. |
| EP2968360B1 (en) | 2013-03-14 | 2021-01-20 | ConverGene LLC | Quinolinone derivatives for the inhibition of bromodomain-containing proteins |
| RU2017121002A (ru) * | 2014-12-03 | 2019-01-11 | ГлаксоСмитКлайн Интеллекчуал Проперти (N2) Лимитед | Ингибиторы CD38 и способы лечения |
| WO2017053604A1 (en) | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Potent antiviral pyrazolopyridine compounds |
| WO2018151830A1 (en) * | 2017-02-17 | 2018-08-23 | Fronthera U.S. Pharmaceuticals Llc | Pyridinyl based apoptosis signal-regulation kinase inhibitors |
| EP3434692A1 (en) | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
| US11180498B2 (en) * | 2017-09-27 | 2021-11-23 | The Regents Of The University Of California | Substituted pyrrolo[2,3-b]pyridines, pyrazolo[3,4-d]pyrimidines and [1,2,3]triazolo[4,5-b]pyridines as potent antivirals |
| US11535621B2 (en) | 2019-07-31 | 2022-12-27 | Ribon Therapeutics, Inc. | Heterobicyclic amides as inhibitors of CD38 |
| TW202128677A (zh) | 2019-10-30 | 2021-08-01 | 美商米突倍基公司 | Cd38抑制劑 |
| IL297128A (en) | 2020-04-07 | 2022-12-01 | Mitobridge Inc | cd38 inhibitors |
| WO2022165114A1 (en) | 2021-01-29 | 2022-08-04 | Ribon Therapeutics, Inc. | Quinolines and azaquinolines as inhibitors of cd38 |
-
2020
- 2020-07-30 US US16/942,857 patent/US11535621B2/en active Active
- 2020-07-30 JP JP2022506169A patent/JP2022542396A/ja active Pending
- 2020-07-30 CA CA3147902A patent/CA3147902A1/en active Pending
- 2020-07-30 TW TW109125742A patent/TW202120496A/zh unknown
- 2020-07-30 MX MX2022001019A patent/MX2022001019A/es unknown
- 2020-07-30 KR KR1020227006571A patent/KR20220061958A/ko unknown
- 2020-07-30 WO PCT/US2020/044156 patent/WO2021021986A1/en unknown
- 2020-07-30 BR BR112022001291A patent/BR112022001291A2/pt unknown
- 2020-07-30 CN CN202080066542.2A patent/CN114423753A/zh active Pending
- 2020-07-30 AU AU2020321956A patent/AU2020321956A1/en active Pending
- 2020-07-30 EP EP20757729.7A patent/EP4003980A1/en active Pending
-
2022
- 2022-01-16 IL IL289878A patent/IL289878A/en unknown
- 2022-12-05 US US18/074,746 patent/US11987584B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20220241261A1 (en) | Combinations of inhibitors of irak4 with inhibitors of btk | |
| US9795607B2 (en) | Substituted pyrrolopyrimidine compounds, compositions thereof, and methods of treatment therewith | |
| JP5167291B2 (ja) | ジヒドロピラゾロピリミジノン誘導体 | |
| JP2019504821A5 (ru) | ||
| ES2373688T3 (es) | Pirrolo[2,3-b]piridinas y pirrolo[2,3-b]pirimidinas sustituidas con heteroarilo como inhibidores de quinasas janus. | |
| JP2018522859A5 (ru) | ||
| TW201840549A (zh) | 2-雜芳基-3-氧代-2,3-二氫噠嗪-4-甲醯胺 | |
| US10023576B2 (en) | Heteroaryl substituted pyrrolotriazine amine compounds as PI3K inhibitors | |
| JP2013523884A5 (ru) | ||
| JPWO2009054332A1 (ja) | ピリドン置換ジヒドロピラゾロピリミジノン誘導体 | |
| EA030376B1 (ru) | Азетидиновые производные пиперидин-4-ила как ингибиторы jak1 | |
| US20170355707A1 (en) | Bicyclic heteroaryl amine compounds | |
| TW202200552A (zh) | 作為用於免疫活化之DGKζ抑制劑之經取代胺基噻唑 | |
| US10894784B2 (en) | Heteroarylbenzimidazole compounds | |
| TW202116753A (zh) | 以噌啉作為hpk1的抑制劑 | |
| US20230406860A1 (en) | Heterocyclic spiro compounds and methods of use | |
| JP2022544952A (ja) | ［１，２，４］トリアゾロ［１，５－ｃ］キナゾリン－５－アミン | |
| JPWO2021021986A5 (ru) | ||
| US20240150356A1 (en) | Pyrimidine amide compounds and use thereof |