JPWO2021021986A5 - - Google Patents
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- Publication number
- JPWO2021021986A5 JPWO2021021986A5 JP2022506169A JP2022506169A JPWO2021021986A5 JP WO2021021986 A5 JPWO2021021986 A5 JP WO2021021986A5 JP 2022506169 A JP2022506169 A JP 2022506169A JP 2022506169 A JP2022506169 A JP 2022506169A JP WO2021021986 A5 JPWO2021021986 A5 JP WO2021021986A5
- Authority
- JP
- Japan
- Prior art keywords
- carboxamide
- imidazol
- alkyl
- pyrimidine
- cyclohexyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962880923P | 2019-07-31 | 2019-07-31 | |
| US62/880,923 | 2019-07-31 | ||
| US201962951604P | 2019-12-20 | 2019-12-20 | |
| US62/951,604 | 2019-12-20 | ||
| US202063034750P | 2020-06-04 | 2020-06-04 | |
| US63/034,750 | 2020-06-04 | ||
| PCT/US2020/044156 WO2021021986A1 (en) | 2019-07-31 | 2020-07-30 | Heterobicyclic amides as inhibitors of cd38 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2022542396A JP2022542396A (ja) | 2022-10-03 |
| JPWO2021021986A5 true JPWO2021021986A5 (pt) | 2023-08-07 |
Family
ID=72139677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506169A Pending JP2022542396A (ja) | 2019-07-31 | 2020-07-30 | Ｃｄ３８の阻害剤としてのヘテロ二環式アミド |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11535621B2 (pt) |
| EP (1) | EP4003980A1 (pt) |
| JP (1) | JP2022542396A (pt) |
| KR (1) | KR20220061958A (pt) |
| CN (1) | CN114423753A (pt) |
| AU (1) | AU2020321956A1 (pt) |
| BR (1) | BR112022001291A2 (pt) |
| CA (1) | CA3147902A1 (pt) |
| IL (1) | IL289878A (pt) |
| MX (1) | MX2022001019A (pt) |
| TW (1) | TW202120496A (pt) |
| WO (1) | WO2021021986A1 (pt) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202120496A (zh) | 2019-07-31 | 2021-06-01 | 美商律幫治療股份有限公司 | 作為cd38抑制劑之雜雙環醯胺 |
| MX2023008701A (es) | 2021-01-29 | 2023-11-29 | Boehringer Ingelheim Int | Quinolinas y azaquinolinas como inhibidores de cumulo de diferenciacion 38 (cd38). |
| KR20240047371A (ko) * | 2021-07-12 | 2024-04-12 | 싸이토키네틱스, 인코포레이티드 | Cd38 조절제 및 이의 사용 방법 |
| CA3236793A1 (en) | 2021-11-09 | 2023-05-19 | Roland Burli | N-(4-aminocyclohexyl)pyrimidine-4-carboxamide derivatives as cd38 inhibitors |
| CN114306366B (zh) * | 2021-11-30 | 2023-01-06 | 合肥康诺生物制药有限公司 | 含nad和cd38抑制剂的药物组合物及其用途 |
| WO2023098699A1 (en) * | 2021-12-01 | 2023-06-08 | Nanjing Immunophage Biotech Co., Ltd | Compounds and their uses as cd38 inhibitors |
| GB202207721D0 (en) * | 2022-05-25 | 2022-07-06 | Cerevance Ltd | Novel Compounds |
| WO2024030000A1 (ko) * | 2022-08-05 | 2024-02-08 | 주식회사 넥스트젠바이오사이언스 | 저산소증 유도 인자 1(hif-1) 억제제 또는 혈관내피성장인자(vegf) 억제제 로서의 신규 화합물 및 이를 포함하는 약학적 조성물 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101679432B (zh) * | 2006-10-19 | 2015-04-22 | 西格诺药品有限公司 | 杂芳基化合物、其组合物及其作为蛋白激酶抑制剂的用途 |
| US8765792B2 (en) * | 2010-12-01 | 2014-07-01 | Glaxosmithkline Llc | Indoles |
| CA2852921C (en) * | 2011-10-19 | 2023-10-10 | Signal Pharmaceuticals, Llc | Treatment of cancer with tor kinase inhibitors |
| CN104039956A (zh) * | 2011-11-04 | 2014-09-10 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 治疗方法 |
| AU2013202305B2 (en) * | 2012-02-24 | 2015-03-12 | Signal Pharmaceuticals, Llc | Methods for treating cancer using TOR kinase inhibitor combination therapy |
| US9695179B2 (en) | 2013-03-14 | 2017-07-04 | Convergene Llc | Methods and compositions for inhibition of bromodomain-containing proteins |
| CA2969178A1 (en) * | 2014-12-03 | 2016-06-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Cd38 inhibitors and methods of treatment |
| WO2017053604A1 (en) * | 2015-09-23 | 2017-03-30 | The Regents Of The University Of California | Potent antiviral pyrazolopyridine compounds |
| WO2018151830A1 (en) | 2017-02-17 | 2018-08-23 | Fronthera U.S. Pharmaceuticals Llc | Pyridinyl based apoptosis signal-regulation kinase inhibitors |
| EP3434692A1 (en) | 2017-07-24 | 2019-01-30 | Encefa | Compounds which specifically binds to cd38 for use in the treatment of neurodegenerative diseases |
| EP3687529B1 (en) * | 2017-09-27 | 2023-07-12 | The Regents of the University of California | Potent antiviral pyridine-containing compounds |
| TW202120496A (zh) | 2019-07-31 | 2021-06-01 | 美商律幫治療股份有限公司 | 作為cd38抑制劑之雜雙環醯胺 |
| WO2021087087A1 (en) | 2019-10-30 | 2021-05-06 | Mitobridge Inc. | N-cyclohexyl-5-(thiazol-5-yl)-1h-indole-7-carboxamide derivatives and related compounds as cd38 inhibitors for increasing nad+ and for the treatment of e.g. muscular disorders |
| BR112022020291A2 (pt) | 2020-04-07 | 2022-12-06 | Mitobridge Inc | Inibidores de cd38 |
| MX2023008701A (es) | 2021-01-29 | 2023-11-29 | Boehringer Ingelheim Int | Quinolinas y azaquinolinas como inhibidores de cumulo de diferenciacion 38 (cd38). |
-
2020
- 2020-07-30 TW TW109125742A patent/TW202120496A/zh unknown
- 2020-07-30 CA CA3147902A patent/CA3147902A1/en active Pending
- 2020-07-30 AU AU2020321956A patent/AU2020321956A1/en active Pending
- 2020-07-30 JP JP2022506169A patent/JP2022542396A/ja active Pending
- 2020-07-30 BR BR112022001291A patent/BR112022001291A2/pt unknown
- 2020-07-30 CN CN202080066542.2A patent/CN114423753A/zh active Pending
- 2020-07-30 EP EP20757729.7A patent/EP4003980A1/en active Pending
- 2020-07-30 US US16/942,857 patent/US11535621B2/en active Active
- 2020-07-30 KR KR1020227006571A patent/KR20220061958A/ko unknown
- 2020-07-30 WO PCT/US2020/044156 patent/WO2021021986A1/en unknown
- 2020-07-30 MX MX2022001019A patent/MX2022001019A/es unknown
-
2022
- 2022-01-16 IL IL289878A patent/IL289878A/en unknown
- 2022-12-05 US US18/074,746 patent/US11987584B2/en active Active
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