JPWO2021021907A5 - - Google Patents
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- JPWO2021021907A5 JPWO2021021907A5 JP2022506196A JP2022506196A JPWO2021021907A5 JP WO2021021907 A5 JPWO2021021907 A5 JP WO2021021907A5 JP 2022506196 A JP2022506196 A JP 2022506196A JP 2022506196 A JP2022506196 A JP 2022506196A JP WO2021021907 A5 JPWO2021021907 A5 JP WO2021021907A5
- Authority
- JP
- Japan
- Prior art keywords
- soluble
- concentration
- interleukin
- cells
- culture medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962881311P | 2019-07-31 | 2019-07-31 | |
| US62/881,311 | 2019-07-31 | ||
| US201962932342P | 2019-11-07 | 2019-11-07 | |
| US62/932,342 | 2019-11-07 | ||
| PCT/US2020/044033 WO2021021907A1 (en) | 2019-07-31 | 2020-07-29 | Methods and compositions for enhanced expansion and cytotoxicity of natural killer cells |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022542399A JP2022542399A (ja) | 2022-10-03 |
| JP2022542399A5 JP2022542399A5 (https=) | 2023-08-03 |
| JPWO2021021907A5 true JPWO2021021907A5 (https=) | 2023-08-03 |
| JP7724765B2 JP7724765B2 (ja) | 2025-08-18 |
Family
ID=74229259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022506196A Active JP7724765B2 (ja) | 2019-07-31 | 2020-07-29 | ナチュラルキラー細胞の増殖を亢進する、および細胞障害性を増強するための方法および組成物 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20220411754A1 (https=) |
| EP (1) | EP4003379A4 (https=) |
| JP (1) | JP7724765B2 (https=) |
| KR (1) | KR20220038439A (https=) |
| CN (1) | CN114450015A (https=) |
| AU (1) | AU2020321354A1 (https=) |
| CA (1) | CA3144724A1 (https=) |
| IL (1) | IL289902A (https=) |
| MX (1) | MX2022001255A (https=) |
| WO (1) | WO2021021907A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| US11629340B2 (en) | 2017-03-03 | 2023-04-18 | Obsidian Therapeutics, Inc. | DHFR tunable protein regulation |
| KR102660336B1 (ko) | 2017-03-27 | 2024-04-26 | 내셔널 유니버시티 오브 싱가포르 | 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도 |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| CN112055717B (zh) | 2018-04-02 | 2024-04-26 | 新加坡国立大学 | 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子 |
| EP3844186A4 (en) | 2018-08-29 | 2022-08-17 | National University of Singapore | METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS |
| US12590148B2 (en) | 2018-11-26 | 2026-03-31 | Nkarta, Inc. | Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy |
| AU2020232691B2 (en) | 2019-03-05 | 2023-06-29 | Nkarta, Inc. | CD19-directed chimeric antigen receptors and uses thereof in immunotherapy |
| JP7629414B2 (ja) * | 2019-06-04 | 2025-02-13 | ンカルタ・インコーポレイテッド | 免疫療法のための操作されたナチュラルキラー細胞と操作されたｔ細胞の組み合わせ |
| KR20230084470A (ko) | 2020-08-14 | 2023-06-13 | 카이트 파마 인코포레이티드 | 면역 세포 기능의 향상 |
| CN116568805A (zh) * | 2020-09-02 | 2023-08-08 | 恩卡尔塔公司 | 工程化自然杀伤细胞的增强扩增和细胞毒性及其用途 |
| AU2022301302A1 (en) | 2021-07-01 | 2024-01-25 | Indapta Therapeutics, Inc. | Engineered natural killer (nk) cells and related methods |
| US20250339528A1 (en) * | 2021-07-28 | 2025-11-06 | Nkarta, Inc. | Selection of optimal cell donors and methods and compositions for enhanced expansion and cytotoxicity of donor cells |
| CN116236461B (zh) * | 2021-12-08 | 2026-03-24 | 深圳先进技术研究院 | 一种氧化还原型纳米颗粒和活细胞载体及其应用 |
| CN120051297A (zh) | 2022-06-30 | 2025-05-27 | 因达普塔治疗公司 | 工程化自然杀伤(nk)细胞与抗体疗法的组合及相关方法 |
| EP4649139A1 (en) * | 2023-02-01 | 2025-11-19 | Nkarta, Inc. | Methods for expanding immune cells and related compositions and uses thereof |
| WO2025150751A1 (ko) * | 2024-01-11 | 2025-07-17 | 사회복지법인 삼성생명공익재단 | Nk 세포의 활성화 및 증폭용 배양보조세포 및 이의 용도 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101684456A (zh) * | 2008-09-28 | 2010-03-31 | 江门罗森生物制药有限公司 | 一种体外培养条件下扩增人nk细胞的方法 |
| AU2015259877B2 (en) * | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| EP3223856B1 (en) * | 2014-10-27 | 2025-09-24 | University of Central Florida Research Foundation, Inc. | Methods and compositions for natural killer cells |
| EP3452580B1 (en) * | 2016-05-02 | 2023-08-16 | Cerus Corporation | Compositions and methods for improved nk cell therapies |
| CN106085958A (zh) * | 2016-08-04 | 2016-11-09 | 英普乐孚生物技术(上海)有限公司 | 一种nk细胞的制备方法 |
| US10300089B2 (en) | 2016-11-08 | 2019-05-28 | University Of Central Florida Research Foundation, Inc. | Methods for high scale therapeutic production of memory NK cells |
| MX2019011570A (es) * | 2017-03-27 | 2019-11-18 | Nat Univ Singapore | Lineas celulares estimuladoras para expansion y activacion ex vivo de celulas asesinas naturales. |
-
2020
- 2020-07-29 MX MX2022001255A patent/MX2022001255A/es unknown
- 2020-07-29 US US17/628,105 patent/US20220411754A1/en active Pending
- 2020-07-29 JP JP2022506196A patent/JP7724765B2/ja active Active
- 2020-07-29 CN CN202080068418.XA patent/CN114450015A/zh active Pending
- 2020-07-29 KR KR1020227005973A patent/KR20220038439A/ko active Pending
- 2020-07-29 CA CA3144724A patent/CA3144724A1/en active Pending
- 2020-07-29 EP EP20848600.1A patent/EP4003379A4/en active Pending
- 2020-07-29 WO PCT/US2020/044033 patent/WO2021021907A1/en not_active Ceased
- 2020-07-29 AU AU2020321354A patent/AU2020321354A1/en active Pending
-
2022
- 2022-01-16 IL IL289902A patent/IL289902A/en unknown
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