CN114450015A - 用于天然杀伤细胞的增强的扩增和细胞毒性的方法和组合物 - Google Patents

用于天然杀伤细胞的增强的扩增和细胞毒性的方法和组合物 Download PDF

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CN114450015A
CN114450015A CN202080068418.XA CN202080068418A CN114450015A CN 114450015 A CN114450015 A CN 114450015A CN 202080068418 A CN202080068418 A CN 202080068418A CN 114450015 A CN114450015 A CN 114450015A
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J.B.特拉格
A.L.L.拉泽蒂奇
I.陈
A.沃拉
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Nkarta Inc
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CN202080068418.XA 2019-07-31 2020-07-29 用于天然杀伤细胞的增强的扩增和细胞毒性的方法和组合物 Pending CN114450015A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962881311P 2019-07-31 2019-07-31
US62/881,311 2019-07-31
US201962932342P 2019-11-07 2019-11-07
US62/932,342 2019-11-07
PCT/US2020/044033 WO2021021907A1 (en) 2019-07-31 2020-07-29 Methods and compositions for enhanced expansion and cytotoxicity of natural killer cells

Publications (1)

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CN114450015A true CN114450015A (zh) 2022-05-06

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CN202080068418.XA Pending CN114450015A (zh) 2019-07-31 2020-07-29 用于天然杀伤细胞的增强的扩增和细胞毒性的方法和组合物

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US (1) US20220411754A1 (https=)
EP (1) EP4003379A4 (https=)
JP (1) JP7724765B2 (https=)
KR (1) KR20220038439A (https=)
CN (1) CN114450015A (https=)
AU (1) AU2020321354A1 (https=)
CA (1) CA3144724A1 (https=)
IL (1) IL289902A (https=)
MX (1) MX2022001255A (https=)
WO (1) WO2021021907A1 (https=)

Cited By (1)

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CN116113689A (zh) * 2020-08-14 2023-05-12 凯德药业股份有限公司 改善免疫细胞功能

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AU2015259877B2 (en) 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
KR102660336B1 (ko) 2017-03-27 2024-04-26 내셔널 유니버시티 오브 싱가포르 절단된 nkg2d 키메라 수용체 및 자연 살해 세포 면역요법에서의 그의 용도
AU2019219454A1 (en) 2018-02-09 2020-08-27 National University Of Singapore Activating chimeric receptors and uses thereof in natural killer cell immunotherapy
CN112055717B (zh) 2018-04-02 2024-04-26 新加坡国立大学 用在免疫细胞中表达的膜结合抗细胞因子非信号传导粘合剂中和人细胞因子
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
US12590148B2 (en) 2018-11-26 2026-03-31 Nkarta, Inc. Methods for the simultaneous expansion of multiple immune cell types, related compositions and uses of same in cancer immunotherapy
AU2020232691B2 (en) 2019-03-05 2023-06-29 Nkarta, Inc. CD19-directed chimeric antigen receptors and uses thereof in immunotherapy
JP7629414B2 (ja) * 2019-06-04 2025-02-13 ンカルタ・インコーポレイテッド 免疫療法のための操作されたナチュラルキラー細胞と操作されたｔ細胞の組み合わせ
CN116568805A (zh) * 2020-09-02 2023-08-08 恩卡尔塔公司 工程化自然杀伤细胞的增强扩增和细胞毒性及其用途
AU2022301302A1 (en) 2021-07-01 2024-01-25 Indapta Therapeutics, Inc. Engineered natural killer (nk) cells and related methods
US20250339528A1 (en) * 2021-07-28 2025-11-06 Nkarta, Inc. Selection of optimal cell donors and methods and compositions for enhanced expansion and cytotoxicity of donor cells
CN116236461B (zh) * 2021-12-08 2026-03-24 深圳先进技术研究院 一种氧化还原型纳米颗粒和活细胞载体及其应用
CN120051297A (zh) 2022-06-30 2025-05-27 因达普塔治疗公司 工程化自然杀伤(nk)细胞与抗体疗法的组合及相关方法
EP4649139A1 (en) * 2023-02-01 2025-11-19 Nkarta, Inc. Methods for expanding immune cells and related compositions and uses thereof
WO2025150751A1 (ko) * 2024-01-11 2025-07-17 사회복지법인 삼성생명공익재단 Nk 세포의 활성화 및 증폭용 배양보조세포 및 이의 용도

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CN106085958A (zh) * 2016-08-04 2016-11-09 英普乐孚生物技术(上海)有限公司 一种nk细胞的制备方法
CN107206100A (zh) * 2014-10-27 2017-09-26 弗罗里达中央大学研究基金会 自然杀伤细胞的方法和组合物
WO2017192440A1 (en) * 2016-05-02 2017-11-09 Cerus Corporation Compositions and methods for improved nk cell therapies
WO2018089476A1 (en) * 2016-11-08 2018-05-17 University Of Central Florida Research Foundation, Inc. Methods and compositions high scale therapeutic production of memory-like nk cells
WO2018182511A1 (en) * 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells

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CN101684456A (zh) * 2008-09-28 2010-03-31 江门罗森生物制药有限公司 一种体外培养条件下扩增人nk细胞的方法
AU2015259877B2 (en) * 2014-05-15 2021-02-25 National University Of Singapore Modified natural killer cells and uses thereof

Patent Citations (5)

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CN107206100A (zh) * 2014-10-27 2017-09-26 弗罗里达中央大学研究基金会 自然杀伤细胞的方法和组合物
WO2017192440A1 (en) * 2016-05-02 2017-11-09 Cerus Corporation Compositions and methods for improved nk cell therapies
CN106085958A (zh) * 2016-08-04 2016-11-09 英普乐孚生物技术(上海)有限公司 一种nk细胞的制备方法
WO2018089476A1 (en) * 2016-11-08 2018-05-17 University Of Central Florida Research Foundation, Inc. Methods and compositions high scale therapeutic production of memory-like nk cells
WO2018182511A1 (en) * 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116113689A (zh) * 2020-08-14 2023-05-12 凯德药业股份有限公司 改善免疫细胞功能
US12551530B2 (en) 2020-08-14 2026-02-17 Kite Pharma, Inc. Immune cell function

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EP4003379A4 (en) 2023-08-30
WO2021021907A1 (en) 2021-02-04
JP7724765B2 (ja) 2025-08-18
CA3144724A1 (en) 2021-02-04
AU2020321354A1 (en) 2022-03-03
JP2022542399A (ja) 2022-10-03
IL289902A (en) 2022-03-01
KR20220038439A (ko) 2022-03-28
MX2022001255A (es) 2022-05-10
US20220411754A1 (en) 2022-12-29
EP4003379A1 (en) 2022-06-01

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