JPWO2021007160A5 - - Google Patents
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- JPWO2021007160A5 JPWO2021007160A5 JP2022500512A JP2022500512A JPWO2021007160A5 JP WO2021007160 A5 JPWO2021007160 A5 JP WO2021007160A5 JP 2022500512 A JP2022500512 A JP 2022500512A JP 2022500512 A JP2022500512 A JP 2022500512A JP WO2021007160 A5 JPWO2021007160 A5 JP WO2021007160A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- independently
- occurrence
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000000217 alkyl group Chemical group 0.000 claims description 59
- 150000003839 salts Chemical class 0.000 claims description 38
- 229910052739 hydrogen Inorganic materials 0.000 claims description 35
- 150000001875 compounds Chemical class 0.000 claims description 34
- 239000001257 hydrogen Substances 0.000 claims description 31
- 150000002431 hydrogen Chemical class 0.000 claims description 22
- 125000003118 aryl group Chemical group 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 14
- 230000001225 therapeutic effect Effects 0.000 claims description 14
- 206010028980 Neoplasm Diseases 0.000 claims description 13
- 125000000623 heterocyclic group Chemical group 0.000 claims description 13
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 125000003342 alkenyl group Chemical group 0.000 claims description 10
- 125000000304 alkynyl group Chemical group 0.000 claims description 10
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 10
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 10
- 125000001072 heteroaryl group Chemical group 0.000 claims description 10
- 201000011510 cancer Diseases 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 8
- 230000028993 immune response Effects 0.000 claims description 7
- DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims description 6
- 230000002708 enhancing effect Effects 0.000 claims description 6
- 125000005647 linker group Chemical group 0.000 claims description 6
- -1 nitro, hydroxy Chemical group 0.000 claims description 6
- 125000004122 cyclic group Chemical group 0.000 claims description 5
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 5
- 230000001939 inductive effect Effects 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 4
- 239000002246 antineoplastic agent Substances 0.000 claims description 4
- 229940041181 antineoplastic drug Drugs 0.000 claims description 4
- 229910052799 carbon Inorganic materials 0.000 claims description 4
- 239000003937 drug carrier Substances 0.000 claims description 4
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 2
- 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 2
- 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 2
- 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
- 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims 9
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 230000002519 immonomodulatory effect Effects 0.000 claims 8
- 108020000411 Toll-like receptor Proteins 0.000 claims 4
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 3
- 206010039491 Sarcoma Diseases 0.000 description 3
- 208000021712 Soft tissue sarcoma Diseases 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
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- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 229920000936 Agarose Polymers 0.000 description 1
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- 229920002971 Heparan sulfate Polymers 0.000 description 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 206010060862 Prostate cancer Diseases 0.000 description 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- 208000032383 Soft tissue cancer Diseases 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940124347 antiarthritic drug Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
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- 125000004429 atom Chemical group 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025005471A JP2025063195A (ja) | 2019-07-05 | 2025-01-15 | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962871051P | 2019-07-05 | 2019-07-05 | |
| US62/871,051 | 2019-07-05 | ||
| US202062971196P | 2020-02-06 | 2020-02-06 | |
| US62/971,196 | 2020-02-06 | ||
| US202062981401P | 2020-02-25 | 2020-02-25 | |
| US62/981,401 | 2020-02-25 | ||
| PCT/US2020/040891 WO2021007160A1 (en) | 2019-07-05 | 2020-07-06 | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025005471A Division JP2025063195A (ja) | 2019-07-05 | 2025-01-15 | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022538690A JP2022538690A (ja) | 2022-09-05 |
| JP2022538690A5 JP2022538690A5 (https=) | 2023-08-03 |
| JPWO2021007160A5 true JPWO2021007160A5 (https=) | 2023-08-03 |
| JP7622031B2 JP7622031B2 (ja) | 2025-01-27 |
Family
ID=71842858
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022500512A Active JP7622031B2 (ja) | 2019-07-05 | 2020-07-06 | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
| JP2025005471A Pending JP2025063195A (ja) | 2019-07-05 | 2025-01-15 | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025005471A Pending JP2025063195A (ja) | 2019-07-05 | 2025-01-15 | トランス－シクロオクテン生体直交型薬剤並びに癌及び免疫療法における使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220259254A1 (https=) |
| EP (1) | EP3993834A1 (https=) |
| JP (2) | JP7622031B2 (https=) |
| CN (1) | CN114340680A (https=) |
| AU (1) | AU2020310853A1 (https=) |
| CA (1) | CA3145889A1 (https=) |
| IL (1) | IL289596A (https=) |
| WO (1) | WO2021007160A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4295917A3 (en) * | 2020-08-07 | 2024-02-28 | Tambo, Inc. | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
| JP2024542021A (ja) | 2021-10-29 | 2024-11-13 | タンボ・インコーポレイテッド | ペイロードのｉｎ ｖｉｖｏ標的化送達用のテトラジンコンジュゲート |
| EP4704904A1 (en) | 2023-05-04 | 2026-03-11 | Tambo, Inc. | Tetrazine-based targeting agents for in vivo delivery of a payload |
| CN121419790A (zh) | 2023-05-18 | 2026-01-27 | 坦博公司 | 反式环辛烯修饰的靶向性蛋白质降解剂缀合物 |
| AU2024300552A1 (en) * | 2023-07-27 | 2026-01-29 | Veraxa Biotech Gmbh | Hydrophilic trans-cyclooctene (hytco) compounds, constructs and conjugates containing the same |
| WO2025059685A1 (en) | 2023-09-15 | 2025-03-20 | Tambo, Inc. | Methods for in vivo targeted delivery of a payload |
| CN117599001B (zh) * | 2023-11-29 | 2025-05-09 | 南京鼓楼医院 | 一种生物正交Janus微球及其制备方法和应用 |
| CN118121704B (zh) * | 2024-02-29 | 2024-12-17 | 中山大学附属第一医院 | 假体周围感染治疗靶点及其应用 |
| WO2025231424A1 (en) * | 2024-05-02 | 2025-11-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Procapped mrna for targeted cell translation |
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-
2020
- 2020-07-06 AU AU2020310853A patent/AU2020310853A1/en active Pending
- 2020-07-06 US US17/624,625 patent/US20220259254A1/en active Pending
- 2020-07-06 EP EP20747277.0A patent/EP3993834A1/en active Pending
- 2020-07-06 CN CN202080049756.9A patent/CN114340680A/zh active Pending
- 2020-07-06 JP JP2022500512A patent/JP7622031B2/ja active Active
- 2020-07-06 WO PCT/US2020/040891 patent/WO2021007160A1/en not_active Ceased
- 2020-07-06 CA CA3145889A patent/CA3145889A1/en active Pending
-
2022
- 2022-01-03 IL IL289596A patent/IL289596A/en unknown
-
2025
- 2025-01-15 JP JP2025005471A patent/JP2025063195A/ja active Pending
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