CA3145889A1 - Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy - Google Patents
Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy Download PDFInfo
- Publication number
- CA3145889A1 CA3145889A1 CA3145889A CA3145889A CA3145889A1 CA 3145889 A1 CA3145889 A1 CA 3145889A1 CA 3145889 A CA3145889 A CA 3145889A CA 3145889 A CA3145889 A CA 3145889A CA 3145889 A1 CA3145889 A1 CA 3145889A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- pharmaceutically acceptable
- cancer
- acceptable salt
- tumor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6903—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being semi-solid, e.g. an ointment, a gel, a hydrogel or a solidifying gel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Materials Engineering (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962871051P | 2019-07-05 | 2019-07-05 | |
| US62/871,051 | 2019-07-05 | ||
| US202062971196P | 2020-02-06 | 2020-02-06 | |
| US62/971,196 | 2020-02-06 | ||
| US202062981401P | 2020-02-25 | 2020-02-25 | |
| US62/981,401 | 2020-02-25 | ||
| PCT/US2020/040891 WO2021007160A1 (en) | 2019-07-05 | 2020-07-06 | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3145889A1 true CA3145889A1 (en) | 2021-01-14 |
Family
ID=71842858
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3145889A Pending CA3145889A1 (en) | 2019-07-05 | 2020-07-06 | Trans-cyclooctene bioorthogonal agents and uses in cancer and immunotherapy |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20220259254A1 (https=) |
| EP (1) | EP3993834A1 (https=) |
| JP (2) | JP7622031B2 (https=) |
| CN (1) | CN114340680A (https=) |
| AU (1) | AU2020310853A1 (https=) |
| CA (1) | CA3145889A1 (https=) |
| IL (1) | IL289596A (https=) |
| WO (1) | WO2021007160A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116056765A (zh) | 2020-08-07 | 2023-05-02 | 坦伯公司 | 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途 |
| WO2023077129A1 (en) | 2021-10-29 | 2023-05-04 | Tambo, Inc. | Tetrazine conjugates for in vivo targeted delivery of a payload |
| CN121419788A (zh) | 2023-05-04 | 2026-01-27 | 坦博公司 | 用于体内递送有效载荷的基于四嗪的靶向剂 |
| EP4713022A1 (en) | 2023-05-18 | 2026-03-25 | Tambo, Inc. | Trans-cyclooctene-modified targeted protein degrader conjugates |
| KR20260046464A (ko) * | 2023-07-27 | 2026-04-07 | 베락사 바이오테크 게엠베하 | 친수성 트랜스-시클로옥텐(hyTCO) 화합물, 이를 포함하는 구조체 및 접합체 |
| WO2025059685A1 (en) | 2023-09-15 | 2025-03-20 | Tambo, Inc. | Methods for in vivo targeted delivery of a payload |
| CN117599001B (zh) * | 2023-11-29 | 2025-05-09 | 南京鼓楼医院 | 一种生物正交Janus微球及其制备方法和应用 |
| CN119424649A (zh) * | 2024-02-29 | 2025-02-14 | 中山大学附属第一医院 | 假体周围感染治疗靶点及其应用 |
| WO2025231424A1 (en) * | 2024-05-02 | 2025-11-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Procapped mrna for targeted cell translation |
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-
2020
- 2020-07-06 WO PCT/US2020/040891 patent/WO2021007160A1/en not_active Ceased
- 2020-07-06 CA CA3145889A patent/CA3145889A1/en active Pending
- 2020-07-06 EP EP20747277.0A patent/EP3993834A1/en active Pending
- 2020-07-06 JP JP2022500512A patent/JP7622031B2/ja active Active
- 2020-07-06 AU AU2020310853A patent/AU2020310853A1/en active Pending
- 2020-07-06 US US17/624,625 patent/US20220259254A1/en active Pending
- 2020-07-06 CN CN202080049756.9A patent/CN114340680A/zh active Pending
-
2022
- 2022-01-03 IL IL289596A patent/IL289596A/en unknown
-
2025
- 2025-01-15 JP JP2025005471A patent/JP2025063195A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL289596A (en) | 2022-03-01 |
| JP7622031B2 (ja) | 2025-01-27 |
| JP2022538690A (ja) | 2022-09-05 |
| AU2020310853A1 (en) | 2022-01-27 |
| EP3993834A1 (en) | 2022-05-11 |
| JP2025063195A (ja) | 2025-04-15 |
| WO2021007160A1 (en) | 2021-01-14 |
| CN114340680A (zh) | 2022-04-12 |
| US20220259254A1 (en) | 2022-08-18 |
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