JPWO2020257191A5 - - Google Patents
Download PDFInfo
- Publication number
- JPWO2020257191A5 JPWO2020257191A5 JP2021561910A JP2021561910A JPWO2020257191A5 JP WO2020257191 A5 JPWO2020257191 A5 JP WO2020257191A5 JP 2021561910 A JP2021561910 A JP 2021561910A JP 2021561910 A JP2021561910 A JP 2021561910A JP WO2020257191 A5 JPWO2020257191 A5 JP WO2020257191A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- amino acid
- tmmp
- terminus
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 86
- 229920001184 polypeptide Polymers 0.000 claims 78
- 102000004196 processed proteins & peptides Human genes 0.000 claims 78
- 150000001413 amino acids Chemical group 0.000 claims 18
- 108010002350 Interleukin-2 Proteins 0.000 claims 14
- 102000000588 Interleukin-2 Human genes 0.000 claims 14
- 230000002519 immonomodulatory effect Effects 0.000 claims 12
- 102000043129 MHC class I family Human genes 0.000 claims 10
- 108091054437 MHC class I family Proteins 0.000 claims 10
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 7
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 7
- 238000006467 substitution reaction Methods 0.000 claims 5
- 102000011786 HLA-A Antigens Human genes 0.000 claims 4
- 108010075704 HLA-A Antigens Proteins 0.000 claims 4
- 108700004922 F42A Proteins 0.000 claims 3
- 102220495631 Putative uncharacterized protein LOC645739_F42A_mutation Human genes 0.000 claims 3
- 102000008949 Histocompatibility Antigens Class I Human genes 0.000 claims 2
- 108010088652 Histocompatibility Antigens Class I Proteins 0.000 claims 2
- 101001133056 Homo sapiens Mucin-1 Proteins 0.000 claims 2
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims 2
- 102100034256 Mucin-1 Human genes 0.000 claims 2
- 102220497892 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11_H16A_mutation Human genes 0.000 claims 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims 2
- 238000012575 bio-layer interferometry Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000001105 regulatory effect Effects 0.000 claims 2
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims 2
- 108010082808 4-1BB Ligand Proteins 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 102100025221 CD70 antigen Human genes 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 101000934356 Homo sapiens CD70 antigen Proteins 0.000 claims 1
- 101001019455 Homo sapiens ICOS ligand Proteins 0.000 claims 1
- 101000914484 Homo sapiens T-lymphocyte activation antigen CD80 Proteins 0.000 claims 1
- 101000764263 Homo sapiens Tumor necrosis factor ligand superfamily member 4 Proteins 0.000 claims 1
- 102100034980 ICOS ligand Human genes 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102100026890 Tumor necrosis factor ligand superfamily member 4 Human genes 0.000 claims 1
- 102100032101 Tumor necrosis factor ligand superfamily member 9 Human genes 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 1
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000833 heterodimer Substances 0.000 claims 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962863754P | 2019-06-19 | 2019-06-19 | |
| US62/863,754 | 2019-06-19 | ||
| PCT/US2020/037919 WO2020257191A1 (en) | 2019-06-19 | 2020-06-16 | Multimeric t-cell modulatory polypeptides and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022536581A JP2022536581A (ja) | 2022-08-18 |
| JPWO2020257191A5 true JPWO2020257191A5 (https=) | 2023-06-16 |
| JP2022536581A5 JP2022536581A5 (https=) | 2023-06-16 |
Family
ID=74040105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021561910A Pending JP2022536581A (ja) | 2019-06-19 | 2020-06-16 | 多量体ｔ細胞調節性ポリペプチド及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20220017597A1 (https=) |
| EP (1) | EP3986448A4 (https=) |
| JP (1) | JP2022536581A (https=) |
| WO (1) | WO2020257191A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3019005A1 (en) * | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| CN116970059A (zh) | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| IL269000B2 (en) | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| TW201920249A (zh) | 2017-09-07 | 2019-06-01 | 美商信號生物製藥公司 | 具有結合位點之t細胞調節多聚體多肽及其使用方法 |
| WO2019139896A1 (en) | 2018-01-09 | 2019-07-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| AU2019401183A1 (en) * | 2018-12-19 | 2021-08-12 | Cue Biopharma, Inc. | Multimeric T-cell modulatory polypeptides and methods of use thereof |
| TW202208395A (zh) | 2020-05-12 | 2022-03-01 | 美商信號生物製藥公司 | 多聚體ｔ細胞調節多肽及其使用方法 |
| EP4211149A4 (en) | 2020-09-09 | 2024-10-09 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS FOR THE TREATMENT OF TYPE 1 DIABETES MELLITUS (T1D) AND METHODS OF USE THEREOF |
| US20240092899A1 (en) * | 2021-02-07 | 2024-03-21 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Bispecific antibody |
| JP2024512470A (ja) * | 2021-03-19 | 2024-03-19 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節ポリペプチド及びその使用方法 |
| JP2024518680A (ja) * | 2021-03-19 | 2024-05-02 | キュー バイオファーマ， インコーポレイテッド | Ｔ細胞調節ポリペプチド及びその使用方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2357960T3 (es) * | 1997-05-08 | 2011-05-04 | Oncothyreon Inc. | Procedimiento para generar células t activadas y células presentadoras de antígenos pulsadas con antígenos. |
| US7696306B2 (en) * | 2003-07-11 | 2010-04-13 | Board of Agents of the University of Nebraska | Compositions and methods for preventing or treating cancer |
| BR112015002091A2 (pt) * | 2012-08-02 | 2017-12-12 | Hoffmann La Roche | método para a produção de um polipeptídeo, polipeptídeo, uso de um polipeptídeo e composição |
| PL3157552T3 (pl) * | 2014-06-18 | 2020-05-18 | Albert Einstein College Of Medicine | Polipeptydy syntac i ich zastosowania |
| EP3328377A4 (en) * | 2015-07-31 | 2019-03-13 | Tarveda Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR IMMUNE ONCOLOGY THERAPIES |
| AU2017225787B2 (en) * | 2016-03-03 | 2021-09-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| AU2017226199A1 (en) * | 2016-03-04 | 2018-09-13 | New York University | Virus vectors expressing multiple epitopes of tumor associated antigens for inducing antitumor immunity |
| CA3019005A1 (en) * | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| BR122020025384B1 (pt) * | 2016-12-13 | 2022-07-12 | Delinia, Inc | Proteínas de fusão e dimérica, usos das mesmas e composição farmacêutica |
| CN116970059A (zh) * | 2016-12-22 | 2023-10-31 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| JP2020510038A (ja) * | 2017-03-09 | 2020-04-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | がんワクチン |
| IL269000B2 (en) * | 2017-03-15 | 2024-06-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| EP3446702A1 (en) * | 2017-08-23 | 2019-02-27 | Medizinische Hochschule Hannover | Synthetic vaccine |
| TW201920249A (zh) * | 2017-09-07 | 2019-06-01 | 美商信號生物製藥公司 | 具有結合位點之t細胞調節多聚體多肽及其使用方法 |
| EP3678691A4 (en) * | 2017-09-07 | 2021-06-09 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
-
2020
- 2020-06-16 JP JP2021561910A patent/JP2022536581A/ja active Pending
- 2020-06-16 WO PCT/US2020/037919 patent/WO2020257191A1/en not_active Ceased
- 2020-06-16 EP EP20826642.9A patent/EP3986448A4/en not_active Withdrawn
-
2021
- 2021-09-30 US US17/490,600 patent/US20220017597A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL272085B2 (en) | Multimeric t-cell modulatory polypeptides and methods of use thereof | |
| JP2021500855A5 (https=) | ||
| IL308851B1 (en) | T cell modulatory multimeric polypeptides and methods of using them | |
| JP2020511949A5 (https=) | ||
| JP2019512222A5 (https=) | ||
| AU2018338192B2 (en) | Chimeric polypeptides and uses thereof | |
| JP2017519491A5 (https=) | ||
| JP2020533273A5 (https=) | ||
| JP2020514375A5 (https=) | ||
| JP2018525006A5 (https=) | ||
| JP2021137024A5 (https=) | ||
| AU2019404285B2 (en) | Multimeric T-cell modulatory polypeptides and methods of use thereof | |
| JPWO2020257191A5 (https=) | ||
| CA3069610A1 (en) | Improved dual specificity polypeptide molecule | |
| JP2017527272A5 (https=) | ||
| NO317836B1 (no) | CTLA4-mutantmolekyl, fremgangsmate for fremstilling og anvendelser derav, inkludert nukleinsyremolekyl som koder for CTLA4-mutantmolekylet, plasmid og vertsvektor-system omfattende nukleinsyremolekylet og farmasoytisk blanding omfattende CTLA-mutantmolekylet. | |
| RS55609B1 (sr) | Fc fuzioni proteini koji sadrže nove linkere ili aranžmane | |
| CN113286621A (zh) | 多聚体t细胞调节多肽及其使用方法 | |
| JPWO2020243315A5 (https=) | ||
| CA3149583A1 (en) | Chimeric proteins in autoimmunity | |
| JPWO2021055594A5 (https=) | ||
| US20240376177A1 (en) | Multimeric t-cell modulatory polypeptides and methods of use thereof | |
| JPWO2021239812A5 (https=) | ||
| CN107207622B (zh) | Hla-b27同二聚体用于癌症治疗的用途 | |
| US20240190933A1 (en) | Antigen Presenting Polypeptide Complexes Bearing TGF-Beta and Methods of Use Thereof |