JP2021500855A5 - - Google Patents
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- Publication number
- JP2021500855A5 JP2021500855A5 JP2020513914A JP2020513914A JP2021500855A5 JP 2021500855 A5 JP2021500855 A5 JP 2021500855A5 JP 2020513914 A JP2020513914 A JP 2020513914A JP 2020513914 A JP2020513914 A JP 2020513914A JP 2021500855 A5 JP2021500855 A5 JP 2021500855A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- mhc class
- terminal
- tmapp
- polypeptides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 313
- 229920001184 polypeptide Polymers 0.000 claims description 301
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 301
- 102000043131 MHC class II family Human genes 0.000 claims description 127
- 108091054438 MHC class II family Proteins 0.000 claims description 127
- 210000004899 c-terminal region Anatomy 0.000 claims description 43
- 230000002519 immonomodulatory effect Effects 0.000 claims description 38
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 33
- 108700018351 Major Histocompatibility Complex Proteins 0.000 claims description 23
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 claims description 23
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 17
- 230000001105 regulatory effect Effects 0.000 claims description 15
- 239000000427 antigen Substances 0.000 claims description 14
- 108091007433 antigens Proteins 0.000 claims description 14
- 102000036639 antigens Human genes 0.000 claims description 14
- 108091008874 T cell receptors Proteins 0.000 claims description 12
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 12
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 102000039446 nucleic acids Human genes 0.000 claims description 6
- 108020004707 nucleic acids Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical class 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 4
- 239000013604 expression vector Substances 0.000 claims description 3
- 239000002773 nucleotide Substances 0.000 claims description 3
- 125000003729 nucleotide group Chemical group 0.000 claims description 3
- 238000003259 recombinant expression Methods 0.000 claims description 3
- 235000001014 amino acid Nutrition 0.000 claims 12
- 102000000588 Interleukin-2 Human genes 0.000 claims 6
- 108010002350 Interleukin-2 Proteins 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 102000008214 Glutamate decarboxylase Human genes 0.000 claims 5
- 108091022930 Glutamate decarboxylase Proteins 0.000 claims 5
- 108010076181 Proinsulin Proteins 0.000 claims 3
- 108700028369 Alleles Proteins 0.000 claims 2
- 108010074708 B7-H1 Antigen Proteins 0.000 claims 2
- 102000015212 Fas Ligand Protein Human genes 0.000 claims 2
- 108010039471 Fas Ligand Protein Proteins 0.000 claims 2
- 102000010789 Interleukin-2 Receptors Human genes 0.000 claims 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 claims 2
- 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 claims 2
- 238000012575 bio-layer interferometry Methods 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 101001100327 Homo sapiens RNA-binding protein 45 Proteins 0.000 claims 1
- 102100038823 RNA-binding protein 45 Human genes 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 229940121354 immunomodulator Drugs 0.000 claims 1
- 230000004957 immunoregulator effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024023312A JP2024063050A (ja) | 2017-09-07 | 2024-02-20 | 抗原提示ポリペプチドおよびその使用方法 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762555526P | 2017-09-07 | 2017-09-07 | |
| US62/555,526 | 2017-09-07 | ||
| US201862692314P | 2018-06-29 | 2018-06-29 | |
| US62/692,314 | 2018-06-29 | ||
| PCT/US2018/049760 WO2019051094A1 (en) | 2017-09-07 | 2018-09-06 | ANTIGEN PRESENTATION POLYPEPTIDES AND METHODS OF USE |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024023312A Division JP2024063050A (ja) | 2017-09-07 | 2024-02-20 | 抗原提示ポリペプチドおよびその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021500855A JP2021500855A (ja) | 2021-01-14 |
| JP2021500855A5 true JP2021500855A5 (https=) | 2021-10-14 |
Family
ID=65634574
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020513914A Pending JP2021500855A (ja) | 2017-09-07 | 2018-09-06 | 抗原提示ポリペプチドおよびその使用方法 |
| JP2024023312A Pending JP2024063050A (ja) | 2017-09-07 | 2024-02-20 | 抗原提示ポリペプチドおよびその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024023312A Pending JP2024063050A (ja) | 2017-09-07 | 2024-02-20 | 抗原提示ポリペプチドおよびその使用方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20200172595A1 (https=) |
| EP (1) | EP3678677A4 (https=) |
| JP (2) | JP2021500855A (https=) |
| KR (1) | KR20200064083A (https=) |
| CN (1) | CN111278864A (https=) |
| AU (1) | AU2018328283A1 (https=) |
| CA (1) | CA3071881A1 (https=) |
| IL (1) | IL272332A (https=) |
| TW (1) | TW201920247A (https=) |
| WO (1) | WO2019051094A1 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017201210A1 (en) * | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| ES2973548T3 (es) | 2016-12-22 | 2024-06-20 | Cue Biopharma Inc | Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso |
| US20200010528A1 (en) | 2017-03-15 | 2020-01-09 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| EP3596108A4 (en) | 2017-03-15 | 2020-12-23 | Pandion Operations, Inc. | TARGETED IMMUNOTOLERANCE |
| US10676516B2 (en) | 2017-05-24 | 2020-06-09 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
| JP2020534352A (ja) | 2017-09-07 | 2020-11-26 | キュー バイオファーマ，インコーポレーテッド | コンジュゲーション部位を有するｔ細胞調節多量体ポリペプチド及びその使用方法 |
| US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| WO2020181272A1 (en) * | 2019-03-06 | 2020-09-10 | Cue Biopharma, Inc. | Antigen-presenting polypeptides with chemical conjugation sites and methods of use thereof |
| EP3935079A4 (en) * | 2019-03-06 | 2023-03-22 | Cue Biopharma, Inc. | T-CELL MODULATING ANTIGEN PRESENT POLYPEPTIDES AND METHODS OF USE THEREOF |
| BR112021023345A2 (pt) | 2019-05-20 | 2022-02-01 | Pandion Operations Inc | Imunotolerância com alvo em madcam |
| TW202128961A (zh) | 2019-11-20 | 2021-08-01 | 美商安維塔生物科學股份有限公司 | 細胞激素融合蛋白及其醫藥組合物及治療應用 |
| EP4107187A4 (en) | 2020-02-21 | 2024-07-03 | Pandion Operations, Inc. | TISSUE-TARGETED IMMUNOTOLERANCE WITH A CD39 EFFECTOR |
| EP4117732A1 (en) * | 2020-03-11 | 2023-01-18 | Ambrx, Inc. | Interleukin-2 polypeptide conjugates and methods of use thereof |
| WO2021222150A2 (en) | 2020-04-28 | 2021-11-04 | Anwita Biosciences, Inc. | Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications |
| WO2021231376A2 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| CN111808170A (zh) * | 2020-06-29 | 2020-10-23 | 江苏为真生物医药技术股份有限公司 | 多肽、hla-dr蛋白及其制备方法和应用 |
| EP4210736A4 (en) * | 2020-09-09 | 2024-10-23 | Cue Biopharma, Inc. | MULTIMERIC POLYPEPTIDES MODULATING MHC CLASS II T CELLS AND METHODS OF USE THEREOF |
| WO2022056014A1 (en) * | 2020-09-09 | 2022-03-17 | Cue Biopharma, Inc. | Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof |
| AU2022238389A1 (en) * | 2021-03-19 | 2023-10-05 | Cue Biopharma, Inc. | T-cell modulatory polypeptides and methods of use thereof |
| WO2022197970A2 (en) * | 2021-03-19 | 2022-09-22 | Cue Biopharma, Inc. | T-cell modulatory polypeptides and methods of use thereof |
| US20240189403A1 (en) * | 2021-04-21 | 2024-06-13 | Cue Biopharma, Inc. | Antigen-Presenting Polypeptides with Chemical Conjugation Sites and Methods of Use Thereof |
| AU2022263441A1 (en) * | 2021-04-21 | 2023-11-09 | Cue Biopharma, Inc. | Antigen presenting polypeptide complexes bearing tgf-beta and methods of use thereof |
| CN117327145A (zh) * | 2022-06-24 | 2024-01-02 | 北京博辉瑞进生物科技有限公司 | 肽、肽修饰的sis膜、其制备方法及应用 |
| JP2025532538A (ja) * | 2022-09-12 | 2025-10-01 | キュー バイオファーマ， インコーポレイテッド | インターロイキン－２ポリペプチド、融合ポリペプチド、およびその使用方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8377447B2 (en) * | 2003-09-05 | 2013-02-19 | Oregon Health & Science University | Monomeric recombinant MHC molecules useful for manipulation of antigen-specific T cells |
| GB2409456B (en) * | 2003-10-30 | 2006-01-04 | Proimmune Ltd | Oligomeric receptor ligand pair member complexes |
| AU2010206840B2 (en) * | 2009-01-21 | 2015-02-05 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| WO2015195531A2 (en) * | 2014-06-18 | 2015-12-23 | Albert Einstein College Of Medicine, Inc. | Syntac polypeptides and uses thereof |
| EP4406604A3 (en) * | 2015-03-05 | 2024-10-23 | Fred Hutchinson Cancer Center | Immunomodulatory fusion proteins and uses thereof |
| EP3400069A4 (en) * | 2016-01-04 | 2019-09-25 | Cour Pharmaceuticals Development Company Inc. | Particles for the Encapsulation of Fusion Proteins with Bundled Epitopes |
| SI3402491T1 (sl) * | 2016-01-11 | 2022-05-31 | Rubius Therapeutics, Inc. | Sestavki in postopki v zvezi z multimodalnimi terapevtskimi celičnimi sistemi za indikacije raka |
| WO2017151818A2 (en) * | 2016-03-02 | 2017-09-08 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| JP7422480B2 (ja) * | 2016-05-04 | 2024-01-26 | アムジエン・インコーポレーテツド | 制御性ｔ細胞の増殖のためのインターロイキン－２変異タンパク質 |
-
2018
- 2018-09-06 EP EP18854499.3A patent/EP3678677A4/en active Pending
- 2018-09-06 KR KR1020207009763A patent/KR20200064083A/ko not_active Ceased
- 2018-09-06 TW TW107131331A patent/TW201920247A/zh unknown
- 2018-09-06 AU AU2018328283A patent/AU2018328283A1/en not_active Abandoned
- 2018-09-06 CA CA3071881A patent/CA3071881A1/en active Pending
- 2018-09-06 CN CN201880068747.7A patent/CN111278864A/zh active Pending
- 2018-09-06 JP JP2020513914A patent/JP2021500855A/ja active Pending
- 2018-09-06 WO PCT/US2018/049760 patent/WO2019051094A1/en not_active Ceased
-
2020
- 2020-01-29 IL IL272332A patent/IL272332A/en unknown
- 2020-02-12 US US16/789,057 patent/US20200172595A1/en not_active Abandoned
-
2023
- 2023-01-31 US US18/103,809 patent/US20240034767A1/en active Pending
-
2024
- 2024-02-20 JP JP2024023312A patent/JP2024063050A/ja active Pending
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