JP2022522404A5 - - Google Patents

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Publication number
JP2022522404A5
JP2022522404A5 JP2021543384A JP2021543384A JP2022522404A5 JP 2022522404 A5 JP2022522404 A5 JP 2022522404A5 JP 2021543384 A JP2021543384 A JP 2021543384A JP 2021543384 A JP2021543384 A JP 2021543384A JP 2022522404 A5 JP2022522404 A5 JP 2022522404A5
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JP
Japan
Prior art keywords
polypeptide
amino acid
acid sequence
mhc class
terminus
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JP2021543384A
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English (en)
Japanese (ja)
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JP2022522404A (ja
JP7691927B2 (ja
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Priority claimed from PCT/US2020/019244 external-priority patent/WO2020180501A1/en
Publication of JP2022522404A publication Critical patent/JP2022522404A/ja
Publication of JP2022522404A5 publication Critical patent/JP2022522404A5/ja
Application granted granted Critical
Publication of JP7691927B2 publication Critical patent/JP7691927B2/ja
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JP2021543384A 2019-03-06 2020-02-21 T細胞調節抗原提示ポリペプチド及びその使用方法 Active JP7691927B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962814715P 2019-03-06 2019-03-06
US62/814,715 2019-03-06
PCT/US2020/019244 WO2020180501A1 (en) 2019-03-06 2020-02-21 T-cell modulatory antigen-presenting polypeptides and methods of use thereof

Publications (3)

Publication Number Publication Date
JP2022522404A JP2022522404A (ja) 2022-04-19
JP2022522404A5 true JP2022522404A5 (https=) 2023-03-01
JP7691927B2 JP7691927B2 (ja) 2025-06-12

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JP2021543384A Active JP7691927B2 (ja) 2019-03-06 2020-02-21 T細胞調節抗原提示ポリペプチド及びその使用方法

Country Status (4)

Country Link
US (1) US20220106378A1 (https=)
EP (1) EP3935079A4 (https=)
JP (1) JP7691927B2 (https=)
WO (1) WO2020180501A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2973548T3 (es) 2016-12-22 2024-06-20 Cue Biopharma Inc Polipéptidos multiméricos moduladores de linfocitos T y métodos para su uso
US20200010528A1 (en) 2017-03-15 2020-01-09 Cue Biopharma, Inc. Methods for modulating an immune response
LT3615674T (lt) 2017-04-28 2024-09-25 The Regents Of The University Of Colorado, A Body Corporate Reumatoidinio artrito gydymo būdai, naudojant nukreipiančios rnr hla geno redagavimą genome
JP2020534352A (ja) 2017-09-07 2020-11-26 キュー バイオファーマ,インコーポレーテッド コンジュゲーション部位を有するt細胞調節多量体ポリペプチド及びその使用方法
WO2021231376A2 (en) 2020-05-12 2021-11-18 Cue Biopharma, Inc. Multimeric t-cell modulatory polypeptides and methods of use thereof
AU2022263441A1 (en) * 2021-04-21 2023-11-09 Cue Biopharma, Inc. Antigen presenting polypeptide complexes bearing tgf-beta and methods of use thereof
WO2022226073A1 (en) * 2021-04-21 2022-10-27 Cue Biopharma, Inc. Mhc class ii t-cell modulatory polypeptides and methods of use thereof
AU2022261908A1 (en) * 2021-04-21 2023-10-05 Cue Biopharma, Inc. Mhc class ii t-cell modulatory polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof
KR20240023035A (ko) 2021-05-10 2024-02-20 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코퍼레이트 자가면역 치료를 위한 hla 조작 방법 및 조성물
WO2022251552A2 (en) * 2021-05-26 2022-12-01 Cue Biopharma, Inc. Antigen presenting polypeptide complexes and methods of use thereof

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5585362A (en) 1989-08-22 1996-12-17 The Regents Of The University Of Michigan Adenovirus vectors for gene therapy
DE69233013T2 (de) 1991-08-20 2004-03-04 The Government Of The United States Of America As Represented By The Secretary Of National Institute Of Health, Office Of Technology Transfer Adenovirus vermittelter gentransfer in den gastrointestinaltrakt
US5252479A (en) 1991-11-08 1993-10-12 Research Corporation Technologies, Inc. Safe vector for gene therapy
FR2688514A1 (fr) 1992-03-16 1993-09-17 Centre Nat Rech Scient Adenovirus recombinants defectifs exprimant des cytokines et medicaments antitumoraux les contenant.
EP1024198A3 (en) 1992-12-03 2002-05-29 Genzyme Corporation Pseudo-adenoviral vectors for the gene therapy of haemophiliae
EP0705344B8 (en) 1993-06-24 2006-05-10 Advec Inc. Adenovirus vectors for gene therapy
AU687117B2 (en) 1993-10-25 1998-02-19 Canji, Inc. Recombinant adenoviral vector and methods of use
WO1996004314A1 (en) * 1994-07-29 1996-02-15 Dade International, Inc. Mhc complexes and uses thereof
US7078387B1 (en) 1998-12-28 2006-07-18 Arch Development Corp. Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors
US6287860B1 (en) 2000-01-20 2001-09-11 Isis Pharmaceuticals, Inc. Antisense inhibition of MEKK2 expression
US6811785B2 (en) * 2001-05-07 2004-11-02 Mount Sinai School Of Medicine Of New York University Multivalent MHC class II—peptide chimeras
EP1578917A4 (en) 2001-07-19 2008-01-23 Perlan Therapeutics Inc MULTIMEDIA PROTEINS AND METHODS FOR THE PRODUCTION AND USE THEREOF
US10105437B2 (en) 2004-04-28 2018-10-23 Btg International Limited Epitopes related to coeliac disease
US7855279B2 (en) 2005-09-27 2010-12-21 Amunix Operating, Inc. Unstructured recombinant polymers and uses thereof
AU2007223855B2 (en) 2006-03-06 2013-05-16 Amunix Operating Inc. Unstructured recombinant polymers and uses thereof
JP2010536341A (ja) 2007-08-15 2010-12-02 アムニクス, インコーポレイテッド 生物学的に活性なポリペプチドの特性を改変するための組成物および方法
ES2610356T3 (es) 2009-02-03 2017-04-27 Amunix Operating Inc. Polipéptidos recombinantes extendidos y composiciones que comprenden los mismos
US9695410B2 (en) * 2010-07-15 2017-07-04 Technion Research & Development Foundation Limited Isolated high affinity entities with T-cell receptor like specificity towards native complexes of MHC class II and glutamic acid decarboxylase (GAD) autoantigenic peptides
US10816554B2 (en) * 2014-04-04 2020-10-27 The Board Of Trustees Of The Leland Stanford Junior University Ligand discovery for T cell receptors
AU2015249592A1 (en) 2014-04-24 2016-12-15 Immusant, Inc. Use of Interleukin-2 for diagnosis of Celiac disease
WO2015195531A2 (en) * 2014-06-18 2015-12-23 Albert Einstein College Of Medicine, Inc. Syntac polypeptides and uses thereof
DK3215528T3 (da) * 2014-11-06 2019-10-07 Hoffmann La Roche Fc-regionvarianter med modificeret FcRn-binding og anvendelsesfremgangsmåder
EP3291832B1 (en) * 2015-05-06 2025-09-03 UTI Limited Partnership Nanoparticle compositions for sustained therapy
CA3014466A1 (en) * 2016-03-03 2017-09-08 Cue Biopharma, Inc. T-cell modulatory multimeric polypeptides and methods of use thereof
CN109689096A (zh) * 2016-05-18 2019-04-26 阿尔伯特爱因斯坦医学院公司 变体pd-l1多肽、t细胞调节性多聚体多肽及其使用方法
US20180127481A1 (en) * 2016-11-09 2018-05-10 Uti Limited Partnership RECOMBINANT pMHC CLASS II MOLECULES
EP3678677A4 (en) * 2017-09-07 2021-06-16 Cue Biopharma, Inc. Antigen-presenting polypeptides and methods of use thereof
WO2022056014A1 (en) * 2020-09-09 2022-03-17 Cue Biopharma, Inc. Mhc class ii t-cell modulatory multimeric polypeptides for treating type 1 diabetes mellitus (t1d) and methods of use thereof

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