JPWO2020234300A5 - - Google Patents
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- JPWO2020234300A5 JPWO2020234300A5 JP2021564088A JP2021564088A JPWO2020234300A5 JP WO2020234300 A5 JPWO2020234300 A5 JP WO2020234300A5 JP 2021564088 A JP2021564088 A JP 2021564088A JP 2021564088 A JP2021564088 A JP 2021564088A JP WO2020234300 A5 JPWO2020234300 A5 JP WO2020234300A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- protein
- amino acid
- domain
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 235000018102 proteins Nutrition 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 16
- 102000004169 proteins and genes Human genes 0.000 claims 16
- 125000003275 alpha amino acid group Chemical group 0.000 claims 13
- 241000342334 Human metapneumovirus Species 0.000 claims 8
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 8
- 230000002163 immunogen Effects 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 8
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 229920001184 polypeptide Polymers 0.000 claims 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims 6
- 102200019524 rs2230199 Human genes 0.000 claims 5
- 235000001014 amino acid Nutrition 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 3
- 102200015465 rs121912304 Human genes 0.000 claims 3
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 102220266229 rs1335299144 Human genes 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 102220468936 Protein unc-13 homolog A_E80N_mutation Human genes 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000005829 trimerization reaction Methods 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19175413 | 2019-05-20 | ||
| EP19175413.4 | 2019-05-20 | ||
| PCT/EP2020/063973 WO2020234300A1 (en) | 2019-05-20 | 2020-05-19 | A subunit vaccine for treatment or prevention of a respiratory tract infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022533318A JP2022533318A (ja) | 2022-07-22 |
| JPWO2020234300A5 true JPWO2020234300A5 (https=) | 2023-05-31 |
| JP2022533318A5 JP2022533318A5 (https=) | 2023-05-31 |
Family
ID=66685352
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021564088A Pending JP2022533318A (ja) | 2019-05-20 | 2020-05-19 | 気道感染の治療または予防のためのサブユニットワクチン |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US12162907B2 (https=) |
| EP (1) | EP3972639A1 (https=) |
| JP (1) | JP2022533318A (https=) |
| KR (1) | KR20220010478A (https=) |
| CN (1) | CN114127101A (https=) |
| AU (1) | AU2020277661A1 (https=) |
| BR (1) | BR112021021637A2 (https=) |
| CA (1) | CA3138064A1 (https=) |
| CL (1) | CL2021002819A1 (https=) |
| CO (1) | CO2021014694A2 (https=) |
| EC (1) | ECSP21079178A (https=) |
| GB (1) | GB2598494B (https=) |
| IL (1) | IL287099A (https=) |
| MX (1) | MX2021013111A (https=) |
| MY (1) | MY208001A (https=) |
| PE (1) | PE20220400A1 (https=) |
| PH (1) | PH12021552736A1 (https=) |
| SA (1) | SA521430813B1 (https=) |
| SG (1) | SG11202110646PA (https=) |
| WO (1) | WO2020234300A1 (https=) |
| ZA (1) | ZA202106883B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8986704B2 (en) | 2012-07-06 | 2015-03-24 | Valneva Austria Gmbh | Mutant fragments of OspA and methods and uses relating thereto |
| WO2018189372A1 (en) | 2017-04-13 | 2018-10-18 | Valneva Austria Gmbh | Multivalent ospa polypeptides and methods and uses relating thereto |
| PH12021552736A1 (en) | 2019-05-20 | 2022-07-11 | Valneva Se | A subunit vaccine for treatment or prevention of a respiratory tract infection |
| CN115698044A (zh) | 2020-04-09 | 2023-02-03 | 瓦尔尼瓦奥地利有限责任公司 | 用于医学用途的包含三种OspA融合蛋白的组合物 |
| CA3174666A1 (en) | 2020-04-09 | 2021-10-14 | Robert Schlegl | Improved methods of producing a lipidated protein |
| NZ798475A (en) | 2020-10-09 | 2026-03-27 | Univ Texas | Prefusion-stabilized hmpv f proteins |
| JP2023549815A (ja) | 2020-11-13 | 2023-11-29 | アイコサバックス， インコーポレイテッド | メタニューモウイルスのためのタンパク質ベースのナノ粒子ワクチン |
| JP2024522385A (ja) * | 2021-04-09 | 2024-06-19 | ヴァルネヴァ エスイー | ヒトメタニューモウイルスワクチン |
| EP4380960A4 (en) * | 2021-08-05 | 2025-07-02 | Univ California | GLYCOMODIFIED FOLDON DOMAINS AND RELATED COMPOSITIONS AND METHODS |
| EP4448802A1 (en) * | 2021-12-16 | 2024-10-23 | Janssen Vaccines & Prevention B.V. | Stabilized pre-fusion hmpv fusion proteins |
| JP2026504862A (ja) | 2023-01-18 | 2026-02-10 | ファイザー・インク | 呼吸器疾患に対するワクチン |
| EP4661905A2 (en) * | 2023-02-06 | 2025-12-17 | Cyanvac LLC | Modified piv5 vaccine vectors: methods of making and uses |
| WO2025126071A1 (en) | 2023-12-14 | 2025-06-19 | Pfizer Inc. | Rna molecules |
| WO2025201243A1 (zh) * | 2024-03-25 | 2025-10-02 | 中国医学科学院医学生物学研究所 | 重组呼吸道合胞病毒融合前f蛋白突变体和其用途 |
| WO2026018181A1 (en) | 2024-07-17 | 2026-01-22 | Pfizer Inc. | Immunogenic compositions and uses thereof |
| CN119176858B (zh) * | 2024-11-22 | 2026-01-09 | 北京华诺泰生物医药科技有限公司 | 一种重组人偏肺病毒融合前f蛋白纯化方法 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5547871A (en) | 1993-01-25 | 1996-08-20 | American Cyanamid Company | Heterologous signal sequences for secretion of insect controlling proteins |
| ATE509102T1 (de) | 1994-07-15 | 2011-05-15 | Univ Iowa Res Found | Immunomodulatorische oligonukleotide |
| AT408721B (de) | 1999-10-01 | 2002-02-25 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung enthaltend ein antigen |
| AT409085B (de) | 2000-01-28 | 2002-05-27 | Cistem Biotechnologies Gmbh | Pharmazeutische zusammensetzung zur immunmodulation und herstellung von vakzinen |
| AU2001281812B2 (en) | 2000-06-08 | 2005-04-07 | Valneva Austria Gmbh | Immunostimulatory oligodeoxynucleotides |
| AT410173B (de) | 2000-06-08 | 2003-02-25 | Cistem Biotechnologies Gmbh | Antigene zusammensetzung |
| US20040170642A1 (en) | 2000-08-17 | 2004-09-02 | Jorg Fritiz | Vaccine which comprises at least one antigen and a cathelididin derived antimicrobial peptide of a derivative thereof |
| AT410635B (de) | 2000-10-18 | 2003-06-25 | Cistem Biotechnologies Gmbh | Vakzin-zusammensetzung |
| US8715922B2 (en) * | 2001-01-19 | 2014-05-06 | ViroNovative | Virus causing respiratory tract illness in susceptible mammals |
| JP4188092B2 (ja) | 2001-05-21 | 2008-11-26 | インターツェル・アクチェンゲゼルシャフト | 免疫促進性オリゴデオキシ核酸分子 |
| JP2005519035A (ja) | 2001-12-07 | 2005-06-30 | インターツェル・アクチェンゲゼルシャフト | 免疫促進性オリゴデオキシヌクレオチド |
| DE10221836A1 (de) * | 2002-05-16 | 2003-12-04 | Lohmann Animal Health Gmbh | Attenuierung von Metapneumovirus |
| ATE485056T1 (de) | 2003-03-24 | 2010-11-15 | Intercell Ag | Verbesserte impfstoffe |
| CN101410519B (zh) | 2003-04-25 | 2013-04-24 | 免疫医疗有限责任公司 | 间质肺病毒株及其在疫苗制剂中以及用作抗原性序列表达载体的用途和繁殖病毒的方法 |
| AU2010264686A1 (en) | 2009-06-24 | 2012-01-19 | Glaxosmithkline Biologicals S.A. | Vaccine |
| US20120315270A1 (en) | 2009-10-21 | 2012-12-13 | The United States Of America, As Represented By The | Rsv immunogens, antibodies and compositions thereof |
| CN102145167A (zh) * | 2010-02-05 | 2011-08-10 | 重庆医科大学附属儿童医院 | 重组人类偏肺病毒疫苗 |
| AU2011258165B2 (en) | 2010-05-26 | 2016-11-17 | Selecta Biosciences, Inc. | Dose selection of adjuvanted synthetic nanocarriers |
| ES2647882T3 (es) | 2011-12-06 | 2017-12-27 | Valneva Austria Gmbh | Compuestos de aluminio para su uso en productos terapéuticos y vacunas |
| MY171210A (en) * | 2013-06-17 | 2019-10-02 | Janssen Vaccines & Prevention Bv | Stabilized soluble pre-fusion rsv f polypeptides |
| CL2013002829A1 (es) | 2013-10-01 | 2014-04-04 | Univ Pontificia Catolica Chile | Formulacion inmunogenica que contiene bcg vivas recombinantes que expresan antigenos de metapneumovirus (hmpv) en una suspension que se prepara a partir de un liofilizado sin la necesidad de adjuvante; su uso farmaceutico; vacuna contra hmpv. |
| EP3236998A1 (en) * | 2014-12-24 | 2017-11-01 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Recombinant metapneumovirus f proteins and their use |
| CA2996762A1 (en) * | 2015-08-31 | 2017-03-09 | Technovax, Inc. | Human respiratory syncytial virus (hrsv) virus-like particles (vlps) based vaccine |
| TW201729835A (zh) | 2015-10-22 | 2017-09-01 | 現代公司 | 呼吸道病毒疫苗 |
| EP3474893A1 (en) | 2016-06-27 | 2019-05-01 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Self-assembling insect ferritin nanoparticles for display of co-assembled trimeric antigens |
| WO2019092002A1 (en) * | 2017-11-07 | 2019-05-16 | Valneva Se | Pharmaceutical compositions for treatment or prevention of viral infections |
| PH12021552736A1 (en) | 2019-05-20 | 2022-07-11 | Valneva Se | A subunit vaccine for treatment or prevention of a respiratory tract infection |
| JP2024522385A (ja) | 2021-04-09 | 2024-06-19 | ヴァルネヴァ エスイー | ヒトメタニューモウイルスワクチン |
-
2020
- 2020-05-19 PH PH1/2021/552736A patent/PH12021552736A1/en unknown
- 2020-05-19 CN CN202080030901.9A patent/CN114127101A/zh active Pending
- 2020-05-19 MY MYPI2021005570A patent/MY208001A/en unknown
- 2020-05-19 AU AU2020277661A patent/AU2020277661A1/en active Pending
- 2020-05-19 GB GB2114836.6A patent/GB2598494B/en active Active
- 2020-05-19 US US17/606,811 patent/US12162907B2/en active Active
- 2020-05-19 KR KR1020217034461A patent/KR20220010478A/ko not_active Ceased
- 2020-05-19 EP EP20726137.1A patent/EP3972639A1/en active Pending
- 2020-05-19 MX MX2021013111A patent/MX2021013111A/es unknown
- 2020-05-19 SG SG11202110646PA patent/SG11202110646PA/en unknown
- 2020-05-19 PE PE2021001766A patent/PE20220400A1/es unknown
- 2020-05-19 WO PCT/EP2020/063973 patent/WO2020234300A1/en not_active Ceased
- 2020-05-19 CA CA3138064A patent/CA3138064A1/en active Pending
- 2020-05-19 BR BR112021021637A patent/BR112021021637A2/pt unknown
- 2020-05-19 JP JP2021564088A patent/JP2022533318A/ja active Pending
-
2021
- 2021-09-17 ZA ZA2021/06883A patent/ZA202106883B/en unknown
- 2021-10-07 IL IL287099A patent/IL287099A/en unknown
- 2021-10-25 EC ECSENADI202179178A patent/ECSP21079178A/es unknown
- 2021-10-26 CL CL2021002819A patent/CL2021002819A1/es unknown
- 2021-10-29 CO CONC2021/0014694A patent/CO2021014694A2/es unknown
- 2021-11-10 SA SA521430813A patent/SA521430813B1/ar unknown
-
2023
- 2023-10-24 US US18/493,004 patent/US12162909B2/en active Active
-
2024
- 2024-10-31 US US18/932,700 patent/US20250171501A1/en active Pending
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