JPWO2022214678A5 - - Google Patents

Info

Publication number

JPWO2022214678A5

JPWO2022214678A5 JP2023554016A JP2023554016A JPWO2022214678A5 JP WO2022214678 A5 JPWO2022214678 A5 JP WO2022214678A5 JP 2023554016 A JP2023554016 A JP 2023554016A JP 2023554016 A JP2023554016 A JP 2023554016A JP WO2022214678 A5 JPWO2022214678 A5 JP WO2022214678A5

Authority

JP

Japan

Prior art keywords

protein

positions

fusion

immunogenic composition

seq

Prior art date

2025-04-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 38
• 239000000203 mixture Substances 0.000 claims 30
• 241000342334 Human metapneumovirus Species 0.000 claims 26
• 230000002163 immunogen Effects 0.000 claims 25
• 230000004927 fusion Effects 0.000 claims 22
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 238000006467 substitution reaction Methods 0.000 claims 9
• 239000002671 adjuvant Substances 0.000 claims 6
• 239000012634 fragment Substances 0.000 claims 6
• 235000001014 amino acid Nutrition 0.000 claims 5
• 102200015465 rs121912304 Human genes 0.000 claims 5
• 102200019524 rs2230199 Human genes 0.000 claims 5
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
• 229940037003 alum Drugs 0.000 claims 4
• 125000000151 cysteine group Chemical class N[C@@H](CS)C(=O)* 0.000 claims 4
• 230000003472 neutralizing effect Effects 0.000 claims 4
• 235000018102 proteins Nutrition 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• 102220266229 rs1335299144 Human genes 0.000 claims 4
• 102220468936 Protein unc-13 homolog A_E80N_mutation Human genes 0.000 claims 3
• 125000000539 amino acid group Chemical group 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 238000000034 method Methods 0.000 claims 3
• 239000000546 pharmaceutical excipient Substances 0.000 claims 3
• 108090000765 processed proteins & peptides Proteins 0.000 claims 3
• 239000004471 Glycine Substances 0.000 claims 2
• 108091005804 Peptidases Proteins 0.000 claims 2
• 239000004365 Protease Substances 0.000 claims 2
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 2
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 2
• 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• UPAZUDUZKTYFBG-HNPUZVNISA-N azane [(2S,3R,4R,5S,6R)-2,5-dihydroxy-6-[[(2R,3R,4R,5S,6R)-6-(hydroxymethyl)-5-phosphonooxy-3-[[(3R)-3-tetradecanoyloxytetradecanoyl]amino]-4-[(3R)-3-tetradecanoyloxytetradecanoyl]oxyoxan-2-yl]oxymethyl]-3-[[(3R)-3-hydroxytetradecanoyl]amino]oxan-4-yl] (3R)-3-hydroxytetradecanoate Chemical compound [NH4+].CCCCCCCCCCCCCC(=O)O[C@H](CCCCCCCCCCC)CC(=O)N[C@H]1[C@H](OC[C@H]2O[C@H](O)[C@H](NC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H](OC(=O)C[C@H](O)CCCCCCCCCCC)[C@@H]2O)O[C@H](CO)[C@@H](OP(O)([O-])=O)[C@@H]1OC(=O)C[C@@H](CCCCCCCCCCC)OC(=O)CCCCCCCCCCCCC UPAZUDUZKTYFBG-HNPUZVNISA-N 0.000 claims 2
• 238000003776 cleavage reaction Methods 0.000 claims 2
• 235000018417 cysteine Nutrition 0.000 claims 2
• 230000037430 deletion Effects 0.000 claims 2
• 238000012217 deletion Methods 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 230000007017 scission Effects 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims 1
• 235000004279 alanine Nutrition 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 210000005220 cytoplasmic tail Anatomy 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 102000037865 fusion proteins Human genes 0.000 claims 1
• 108020001507 fusion proteins Proteins 0.000 claims 1
• 230000005847 immunogenicity Effects 0.000 claims 1
• 208000015181 infectious disease Diseases 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 229920001184 polypeptide Polymers 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• 238000005829 trimerization reaction Methods 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1